Determination of lesion volume by MRI and stereology in a macaque model of tuberculosis

SUMMARY Sensitive and reproducible methods are needed to measure the impact on the host following experimental challenge with Mycobacterium tuberculosis , in order to determine the degree of protection conferred by new vaccines. Here we compare how well different clinical and post-mortem measures of...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2009-11, Vol.89 (6), p.405-416
Hauptverfasser:	Sharpe, S.A, Eschelbach, E, Basaraba, R.J, Gleeson, F, Hall, G.A, McIntyre, A, Williams, A, Kraft, S.L, Clark, S, Gooch, K, Hatch, G, Orme, I.M, Marsh, P.D, Dennis, M.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols Animals Cynomolgus Disease Models, Animal Infectious Disease Lung - immunology Lung - pathology Macaca Macaca mulatta Magnetic Resonance Imaging Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - pathogenicity Non-human primate Pathology Pulmonary/Respiratory Reproducibility of Results Stereology Tuberculosis Tuberculosis Vaccines - pharmacology Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - pathology
Online-Zugang:	Volltext
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