Effect of RF-Amide-Related Peptide-3 on Luteinizing Hormone and Follicle-Stimulating Hormone Synthesis and Secretion in Ovine Pituitary Gonadotropes

GnRH provides the primary stimulus for the reproductive axis, but original work also revealed the existence of a gonadotropin-inhibitory hormone (GnIH) in birds. In mammals, GnIH properties are displayed by a hypothalamic dodecapeptide, which is a member of the RF-amide family, namely RF-amide-relat...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2009-12, Vol.150 (12), p.5549-5556
Hauptverfasser:	Sari, Ika P, Rao, Alexandra, Smith, Jeremy T, Tilbrook, Alan J, Clarke, Iain J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell culture Cells, Cultured Female Follicle Stimulating Hormone, beta Subunit - genetics Follicle Stimulating Hormone, beta Subunit - metabolism Follicle-stimulating hormone Gene Expression - drug effects Genes Gonadotrophs - drug effects Gonadotrophs - metabolism Gonadotrophs - secretion Gonadotropin-releasing hormone Gonadotropin-Releasing Hormone - pharmacology Gonadotropins Growth Hormone - genetics Growth hormones Hypothalamus Immunoblotting Luteinizing hormone Luteinizing Hormone, beta Subunit - genetics Luteinizing Hormone, beta Subunit - metabolism Male Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Neuropeptides - pharmacology Peptides Phosphorylation Phosphorylation - drug effects Pituitary Pituitary (anterior) Pituitary Gland - cytology Pituitary Gland - drug effects Pituitary Gland - metabolism Pro-Opiomelanocortin - genetics Prolactin Prolactin - genetics Proopiomelanocortin Radioimmunoassay Real time Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Secretion Sheep Synthesis Western blotting
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