The functional role of the medio dorsal thalamic nucleus in olfaction
Abstract Olfaction is unique relative to other sensory modalities in terms of how its neuroanatomy is organized within the brain and its perceptual properties. Olfactory information processing occurs via connections made directly from primary processing areas (piriform cortex) to neocortical structu...
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| Veröffentlicht in: | Brain Research Reviews 2009-12, Vol.62 (1), p.109-126 |
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| creator | Tham, Wendy W.P Stevenson, Richard J Miller, Laurie A |
| description | Abstract Olfaction is unique relative to other sensory modalities in terms of how its neuroanatomy is organized within the brain and its perceptual properties. Olfactory information processing occurs via connections made directly from primary processing areas (piriform cortex) to neocortical structures (orbitofrontal cortex) as well as indirectly via the medio-dorsal nucleus of the thalamus (MDNT). To date, little is known about the functional significance of the MDNT in olfactory information processing. The aim of this article is to review and discuss thalamic function in olfaction. We draw upon research in human neuroimaging, neuropsychology, as well as animal and neurophysiological studies on the thalamus and MDNT in general, before focusing our discussion on the effects of MDNT lesions specific to olfactory function. Finally, although these data are currently limited and sometimes conflicting, especially those based upon human pathology, the putative roles of the MDNT in olfactory information processing and notably its role in attention, are discussed. |
| doi_str_mv | 10.1016/j.brainresrev.2009.09.007 |
| format | Article |
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Olfactory information processing occurs via connections made directly from primary processing areas (piriform cortex) to neocortical structures (orbitofrontal cortex) as well as indirectly via the medio-dorsal nucleus of the thalamus (MDNT). To date, little is known about the functional significance of the MDNT in olfactory information processing. The aim of this article is to review and discuss thalamic function in olfaction. We draw upon research in human neuroimaging, neuropsychology, as well as animal and neurophysiological studies on the thalamus and MDNT in general, before focusing our discussion on the effects of MDNT lesions specific to olfactory function. Finally, although these data are currently limited and sometimes conflicting, especially those based upon human pathology, the putative roles of the MDNT in olfactory information processing and notably its role in attention, are discussed.</description><identifier>ISSN: 0165-0173</identifier><identifier>EISSN: 1872-6321</identifier><identifier>DOI: 10.1016/j.brainresrev.2009.09.007</identifier><identifier>PMID: 19800366</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Cerebral Cortex - physiology ; Fundamental and applied biological sciences. Psychology ; Human olfaction ; Humans ; Information processing ; Medio-dorsal nucleus ; Mediodorsal Thalamic Nucleus - physiology ; Neurology ; Neurons - physiology ; Olfactory Pathways - physiology ; Olfactory system and olfaction. 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Psychology</topic><topic>Human olfaction</topic><topic>Humans</topic><topic>Information processing</topic><topic>Medio-dorsal nucleus</topic><topic>Mediodorsal Thalamic Nucleus - physiology</topic><topic>Neurology</topic><topic>Neurons - physiology</topic><topic>Olfactory Pathways - physiology</topic><topic>Olfactory system and olfaction. Gustatory system and gustation</topic><topic>Smell - physiology</topic><topic>Thalamus</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tham, Wendy W.P</creatorcontrib><creatorcontrib>Stevenson, Richard J</creatorcontrib><creatorcontrib>Miller, Laurie A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain Research Reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tham, Wendy W.P</au><au>Stevenson, Richard J</au><au>Miller, Laurie A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The functional role of the medio dorsal thalamic nucleus in olfaction</atitle><jtitle>Brain Research Reviews</jtitle><addtitle>Brain Res Rev</addtitle><date>2009-12-11</date><risdate>2009</risdate><volume>62</volume><issue>1</issue><spage>109</spage><epage>126</epage><pages>109-126</pages><issn>0165-0173</issn><eissn>1872-6321</eissn><abstract>Abstract Olfaction is unique relative to other sensory modalities in terms of how its neuroanatomy is organized within the brain and its perceptual properties. 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| subjects | Animals Biological and medical sciences Cerebral Cortex - physiology Fundamental and applied biological sciences. Psychology Human olfaction Humans Information processing Medio-dorsal nucleus Mediodorsal Thalamic Nucleus - physiology Neurology Neurons - physiology Olfactory Pathways - physiology Olfactory system and olfaction. Gustatory system and gustation Smell - physiology Thalamus Vertebrates: nervous system and sense organs |
| title | The functional role of the medio dorsal thalamic nucleus in olfaction |
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