Chronic inhibition of farnesyl pyrophosphate synthase attenuates cardiac hypertrophy and fibrosis in spontaneously hypertensive rats

Farnesyl pyrophosphate synthase (FPPS), an essential enzyme in the mevalonate pathway, was reported to be upregulated in young spontaneously hypertensive rats (SHR) when compared with Wistar–Kyoto (WKY) rats, and this was accompanied by development of left ventricular hypertrophy. Five-week-old rats...

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Veröffentlicht in:	Biochemical pharmacology 2010-02, Vol.79 (3), p.399-406
Hauptverfasser:	Li, Liang, Chen, Guo-Ping, Yang, Yin, Ye, Yang, Yao, Lei, Hu, Shen-Jiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Alendronate Alendronate - administration & dosage Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiac hypertrophy Cardiology. Vascular system Cardiomegaly - enzymology Cardiomegaly - pathology Cardiomegaly - prevention & control Dose-Response Relationship, Drug Enzyme Inhibitors - administration & dosage Farnesyl diphosphate synthase Fibrosis Geranyltranstransferase - antagonists & inhibitors Geranyltranstransferase - metabolism Hypertension - enzymology Hypertension - pathology Hypertension - prevention & control Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred SHR Rats, Inbred WKY Spontaneously hypertensive rat
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