Oral immunization of raccoons and skunks with a canine adenovirus recombinant rabies vaccine
Abstract Oral vaccination is an important part of wildlife rabies control programs. Currently, the vaccinia-rabies glycoprotein recombinant virus is the only oral rabies vaccine licensed in the United States, and it is not effective in skunks. In the current study, captive raccoons and skunks were u...
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| Veröffentlicht in: | Vaccine 2009-11, Vol.27 (51), p.7194-7197 |
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| creator | Henderson, Heather Jackson, Felix Bean, Kayla Panasuk, Brian Niezgoda, Michael Slate, Dennis Li, Jianwei Dietzschold, Bernard Mattis, Jeff Rupprecht, Charles E |
| description | Abstract Oral vaccination is an important part of wildlife rabies control programs. Currently, the vaccinia-rabies glycoprotein recombinant virus is the only oral rabies vaccine licensed in the United States, and it is not effective in skunks. In the current study, captive raccoons and skunks were used to evaluate a vaccine developed by incorporating the rabies virus glycoprotein gene into a canine adenovirus serotype 2 vector (CAV2-RVG). Seven of 7 raccoons orally vaccinated with CAV2-RVG developed virus neutralizing antibodies and survived lethal challenge. Five of 5 and 6 of 6 skunks in 2 experimental groups receiving 10-fold different dilutions of CAV2-RVG developed neutralizing antibodies and survived challenge. The results of this preliminary study suggest that CAV2-RVG stimulates protective immunity against rabies in raccoons and skunks. |
| doi_str_mv | 10.1016/j.vaccine.2009.09.030 |
| format | Article |
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Currently, the vaccinia-rabies glycoprotein recombinant virus is the only oral rabies vaccine licensed in the United States, and it is not effective in skunks. In the current study, captive raccoons and skunks were used to evaluate a vaccine developed by incorporating the rabies virus glycoprotein gene into a canine adenovirus serotype 2 vector (CAV2-RVG). Seven of 7 raccoons orally vaccinated with CAV2-RVG developed virus neutralizing antibodies and survived lethal challenge. Five of 5 and 6 of 6 skunks in 2 experimental groups receiving 10-fold different dilutions of CAV2-RVG developed neutralizing antibodies and survived challenge. The results of this preliminary study suggest that CAV2-RVG stimulates protective immunity against rabies in raccoons and skunks.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2009.09.030</identifier><identifier>PMID: 19925952</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adenovirus ; Adenoviruses, Canine - immunology ; Administration, Oral ; Allergy and Immunology ; Animal control ; Animal euthanasia ; Animals ; Antibodies ; Antibodies, Neutralizing ; Antibodies, Viral - blood ; DNA, Viral - analysis ; Dogs ; Immunization ; Licensed products ; Mephitidae - immunology ; Mephitidae - virology ; Neutralization Tests ; Oral ; Rabies ; Rabies - immunology ; Rabies - prevention & control ; Rabies - veterinary ; Rabies Vaccines - administration & dosage ; Rabies Vaccines - immunology ; Rabies virus ; Raccoons - immunology ; Raccoons - virology ; Vaccine ; Vaccines ; Vaccines, Synthetic - immunology ; Virus Shedding ; Wildlife</subject><ispartof>Vaccine, 2009-11, Vol.27 (51), p.7194-7197</ispartof><rights>2009</rights><rights>Copyright Elsevier Limited Nov 27, 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-73c3f9ef5a9a6626e8466bbb059c9767b5a9d181024965f91db7220426b21e793</citedby><cites>FETCH-LOGICAL-c509t-73c3f9ef5a9a6626e8466bbb059c9767b5a9d181024965f91db7220426b21e793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X09013541$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19925952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Henderson, Heather</creatorcontrib><creatorcontrib>Jackson, Felix</creatorcontrib><creatorcontrib>Bean, Kayla</creatorcontrib><creatorcontrib>Panasuk, Brian</creatorcontrib><creatorcontrib>Niezgoda, Michael</creatorcontrib><creatorcontrib>Slate, Dennis</creatorcontrib><creatorcontrib>Li, Jianwei</creatorcontrib><creatorcontrib>Dietzschold, Bernard</creatorcontrib><creatorcontrib>Mattis, Jeff</creatorcontrib><creatorcontrib>Rupprecht, Charles E</creatorcontrib><title>Oral immunization of raccoons and skunks with a canine adenovirus recombinant rabies vaccine</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract Oral vaccination is an important part of wildlife rabies control programs. Currently, the vaccinia-rabies glycoprotein recombinant virus is the only oral rabies vaccine licensed in the United States, and it is not effective in skunks. In the current study, captive raccoons and skunks were used to evaluate a vaccine developed by incorporating the rabies virus glycoprotein gene into a canine adenovirus serotype 2 vector (CAV2-RVG). Seven of 7 raccoons orally vaccinated with CAV2-RVG developed virus neutralizing antibodies and survived lethal challenge. Five of 5 and 6 of 6 skunks in 2 experimental groups receiving 10-fold different dilutions of CAV2-RVG developed neutralizing antibodies and survived challenge. The results of this preliminary study suggest that CAV2-RVG stimulates protective immunity against rabies in raccoons and skunks.</description><subject>Adenovirus</subject><subject>Adenoviruses, Canine - immunology</subject><subject>Administration, Oral</subject><subject>Allergy and Immunology</subject><subject>Animal control</subject><subject>Animal euthanasia</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Neutralizing</subject><subject>Antibodies, Viral - blood</subject><subject>DNA, Viral - analysis</subject><subject>Dogs</subject><subject>Immunization</subject><subject>Licensed products</subject><subject>Mephitidae - immunology</subject><subject>Mephitidae - virology</subject><subject>Neutralization Tests</subject><subject>Oral</subject><subject>Rabies</subject><subject>Rabies - immunology</subject><subject>Rabies - prevention & control</subject><subject>Rabies - veterinary</subject><subject>Rabies Vaccines - administration & dosage</subject><subject>Rabies Vaccines - immunology</subject><subject>Rabies virus</subject><subject>Raccoons - immunology</subject><subject>Raccoons - virology</subject><subject>Vaccine</subject><subject>Vaccines</subject><subject>Vaccines, Synthetic - immunology</subject><subject>Virus Shedding</subject><subject>Wildlife</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkl2L1DAUhoMo7uzoT1ACgl51PCdp0-ZGkcVVYWEvVPBCCGmaYmbaZE3akfXXmzKFhb1w4UAu8pz3fLyHkBcIOwQUb_e7ozbGebtjAHK3BIdHZINNzQtWYfOYbICJsigRfpyR85T2AFBxlE_JGUrJKlmxDfl5HfVA3TjO3v3Vkwuehp7GLB2CT1T7jqbD7A-J_nHTL6qp0T4XpbqzPhxdnBON1oSxdV77KSe2zia6tvaMPOn1kOzz9d2S75cfv118Lq6uP325-HBVmArkVNTc8F7avtJSC8GEbUoh2raFShpZi7rNHx02CKyUouoldm3NGJRMtAxtLfmWvDnp3sTwe7ZpUqNLxg6D9jbMSdW8xFLWefotef1fkiErgecVPgxCKRBEBl_dA_dhjj6Pq1BgI1E2uHRYnSgTQ0rR9uomulHHW4WgFj_VXq1LU4ufagkOOe_lqj63o-3uslYDM_D-BNi836OzUSXjrDe2c9mXSXXBPVji3T0FMzjvjB4O9tamu2lUYgrU1-WolpsCCcirEvk_mXHHcQ</recordid><startdate>20091127</startdate><enddate>20091127</enddate><creator>Henderson, Heather</creator><creator>Jackson, Felix</creator><creator>Bean, Kayla</creator><creator>Panasuk, Brian</creator><creator>Niezgoda, Michael</creator><creator>Slate, Dennis</creator><creator>Li, Jianwei</creator><creator>Dietzschold, Bernard</creator><creator>Mattis, Jeff</creator><creator>Rupprecht, Charles E</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20091127</creationdate><title>Oral immunization of raccoons and skunks with a canine adenovirus recombinant rabies vaccine</title><author>Henderson, Heather ; Jackson, Felix ; Bean, Kayla ; Panasuk, Brian ; Niezgoda, Michael ; Slate, Dennis ; Li, Jianwei ; Dietzschold, Bernard ; Mattis, Jeff ; Rupprecht, Charles E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-73c3f9ef5a9a6626e8466bbb059c9767b5a9d181024965f91db7220426b21e793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adenovirus</topic><topic>Adenoviruses, Canine - immunology</topic><topic>Administration, Oral</topic><topic>Allergy and Immunology</topic><topic>Animal control</topic><topic>Animal euthanasia</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Neutralizing</topic><topic>Antibodies, Viral - blood</topic><topic>DNA, Viral - analysis</topic><topic>Dogs</topic><topic>Immunization</topic><topic>Licensed products</topic><topic>Mephitidae - immunology</topic><topic>Mephitidae - virology</topic><topic>Neutralization Tests</topic><topic>Oral</topic><topic>Rabies</topic><topic>Rabies - immunology</topic><topic>Rabies - prevention & control</topic><topic>Rabies - veterinary</topic><topic>Rabies Vaccines - administration & dosage</topic><topic>Rabies Vaccines - immunology</topic><topic>Rabies virus</topic><topic>Raccoons - immunology</topic><topic>Raccoons - virology</topic><topic>Vaccine</topic><topic>Vaccines</topic><topic>Vaccines, Synthetic - immunology</topic><topic>Virus Shedding</topic><topic>Wildlife</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Henderson, Heather</creatorcontrib><creatorcontrib>Jackson, Felix</creatorcontrib><creatorcontrib>Bean, Kayla</creatorcontrib><creatorcontrib>Panasuk, Brian</creatorcontrib><creatorcontrib>Niezgoda, Michael</creatorcontrib><creatorcontrib>Slate, Dennis</creatorcontrib><creatorcontrib>Li, Jianwei</creatorcontrib><creatorcontrib>Dietzschold, Bernard</creatorcontrib><creatorcontrib>Mattis, Jeff</creatorcontrib><creatorcontrib>Rupprecht, Charles E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henderson, Heather</au><au>Jackson, Felix</au><au>Bean, Kayla</au><au>Panasuk, Brian</au><au>Niezgoda, Michael</au><au>Slate, Dennis</au><au>Li, Jianwei</au><au>Dietzschold, Bernard</au><au>Mattis, Jeff</au><au>Rupprecht, Charles E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral immunization of raccoons and skunks with a canine adenovirus recombinant rabies vaccine</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2009-11-27</date><risdate>2009</risdate><volume>27</volume><issue>51</issue><spage>7194</spage><epage>7197</epage><pages>7194-7197</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>Abstract Oral vaccination is an important part of wildlife rabies control programs. Currently, the vaccinia-rabies glycoprotein recombinant virus is the only oral rabies vaccine licensed in the United States, and it is not effective in skunks. In the current study, captive raccoons and skunks were used to evaluate a vaccine developed by incorporating the rabies virus glycoprotein gene into a canine adenovirus serotype 2 vector (CAV2-RVG). Seven of 7 raccoons orally vaccinated with CAV2-RVG developed virus neutralizing antibodies and survived lethal challenge. Five of 5 and 6 of 6 skunks in 2 experimental groups receiving 10-fold different dilutions of CAV2-RVG developed neutralizing antibodies and survived challenge. The results of this preliminary study suggest that CAV2-RVG stimulates protective immunity against rabies in raccoons and skunks.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>19925952</pmid><doi>10.1016/j.vaccine.2009.09.030</doi><tpages>4</tpages></addata></record> |
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| subjects | Adenovirus Adenoviruses, Canine - immunology Administration, Oral Allergy and Immunology Animal control Animal euthanasia Animals Antibodies Antibodies, Neutralizing Antibodies, Viral - blood DNA, Viral - analysis Dogs Immunization Licensed products Mephitidae - immunology Mephitidae - virology Neutralization Tests Oral Rabies Rabies - immunology Rabies - prevention & control Rabies - veterinary Rabies Vaccines - administration & dosage Rabies Vaccines - immunology Rabies virus Raccoons - immunology Raccoons - virology Vaccine Vaccines Vaccines, Synthetic - immunology Virus Shedding Wildlife |
| title | Oral immunization of raccoons and skunks with a canine adenovirus recombinant rabies vaccine |
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