The effects of low oxygen on self-renewal and differentiation of embryonic stem cells

To summarize recent reports on the effects of low oxygen on the undifferentiated phenotype and differentiation of embryonic stem cells (ESCs). The oxygen level to which ESCs are exposed is an important environmental parameter. Under conditions maintaining the undifferentiated phenotype, low oxygen r...

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Veröffentlicht in:	Current opinion in organ transplantation 2009-12, Vol.14 (6), p.694-700
Hauptverfasser:	Millman, Jeffrey R, Tan, Jit Hin, Colton, Clark K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Culture Techniques Cell Differentiation Cell Hypoxia Cell Proliferation Embryonic Stem Cells - metabolism Embryonic Stem Cells - pathology Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Models, Biological Oxygen - metabolism Phenotype Pluripotent Stem Cells - metabolism Pluripotent Stem Cells - pathology
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