Facilitation of RNA Enzyme Activity in the Molecular Crowding Media of Cosolutes

Short RNA sequences exhibiting the activity of a target RNA cleavage are promising for cellular gene regulation and biosensor research, but the reaction media different from an aqueous solution may cause unanticipated molecular interactions and properties. In this study, we investigated the molecula...

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Veröffentlicht in:	Journal of the American Chemical Society 2009-11, Vol.131 (46), p.16881-16888
Hauptverfasser:	Nakano, Shu-ichi, Karimata, Hisae Tateishi, Kitagawa, Yuichi, Sugimoto, Naoki
Format:	Artikel
Sprache:	eng
Schlagworte:	Hydrolysis Nucleic Acid Conformation Polyethylene Glycols - chemistry RNA - chemistry RNA Stability RNA, Catalytic - chemistry
Online-Zugang:	Volltext
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