A kinome of 2600 in the ciliate Paramecium tetraurelia
Protein kinases play a crucial role in the regulation of cellular processes. Most eukaryotes reserve about 2.5% of their genes for protein kinases. We analysed the genome of the single-celled ciliate Paramecium tetraurelia and identified 2606 kinases, about 6.6% of its genes, representing the larges...
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| Veröffentlicht in: | FEBS letters 2009-11, Vol.583 (22), p.3589-3592 |
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| creator | Bemm, Felix Schwarz, Roland Förster, Frank Schultz, Jörg |
| description | Protein kinases play a crucial role in the regulation of cellular processes. Most eukaryotes reserve about 2.5% of their genes for protein kinases. We analysed the genome of the single-celled ciliate Paramecium tetraurelia and identified 2606 kinases, about 6.6% of its genes, representing the largest kinome to date. A gene tree combined with human kinases revealed a massive expansion of the calcium calmodulin regulated subfamily, underlining the importance of calcium in the physiology of P. tetraurelia. The kinases are embedded in only 40 domain architectures, contrasting 134 in human. This might indicate different mechanisms to achieve target specificity. |
| doi_str_mv | 10.1016/j.febslet.2009.10.029 |
| format | Article |
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| ispartof | FEBS letters, 2009-11, Vol.583 (22), p.3589-3592 |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Binding Sites - genetics Computational Biology - methods Domain Gene Expression Profiling - methods Genome Genome, Protozoan - genetics Humans Kinase Paramecium tetraurelia Paramecium tetraurelia - enzymology Paramecium tetraurelia - genetics Phylogeny Protein Kinases - classification Protein Kinases - genetics Protozoan Proteins - genetics Sequence analysis |
| title | A kinome of 2600 in the ciliate Paramecium tetraurelia |
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