Effects of curcumin for preventing restenosis in a hypercholesterolemic rabbit iliac artery stent model
Objective: To evaluate the efficacy of the curcumin‐coating stent (CCS) on the inhibition of restenosis in a rabbit iliac artery stent model. Results: Curcumin, pigment naturally acquired from the rhizome of the plant curcuma longa, is known to have antiproliferative, antimigratory, and anti‐inflamm...
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| Veröffentlicht in: | Catheterization and cardiovascular interventions 2009-11, Vol.74 (6), p.881-888 |
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| creator | Jang, Hyung-Suk Nam, Hye Yeong Kim, Jeong-Min Hahm, Dong-Hoon Nam, So Hee Kim, Koung Li Joo, Jae-Ryang Suh, Wonhee Park, Jong-Sang Kim, Duk Kyung Gwon, Hyeon-Cheol |
| description | Objective:
To evaluate the efficacy of the curcumin‐coating stent (CCS) on the inhibition of restenosis in a rabbit iliac artery stent model.
Results:
Curcumin, pigment naturally acquired from the rhizome of the plant curcuma longa, is known to have antiproliferative, antimigratory, and anti‐inflammatory effects. However, it is still unclear that curcumin can inhibit neointimal proliferation of the injured vessel.
Methods:
Dose‐dependent inhibition of cell growth was observed over a dose range from 10 nM to 10 μM. CCS was prepared by a dip‐coating method (high‐dose: HD, low‐dose: LD). The release profile of the HD CCS showed that drug release persisted until day 21. Scanning electron microscopy of the CCS showed an intact surface of the stent even after expansion. To test the efficacy of CCS in vivo, LD CCS, HD CCS, and bare metal stents (BMS) were implanted in random order in one iliac artery (N = 30 arteries) of male New Zealand White rabbits (N = 15).
Results:
After 28 days, the LD and HD CCS groups had a 43% and 55% reduction in the neointimal area, compared with the BMS group (BMS 3.3 ± 1.0 mm2, LD 1.9 ± 0.8 mm2, and HD 0.9 ± 0.5 mm2, P < 0.05). There appeared to be no cytotoxicity related to curcumin at the indicated doses.
Conclusions:
Curcumin, a natural compound in the human diet, seems to be a safe and effective candidate drug for use in a drug‐eluting stent for the prevention of stent restenosis following angioplasty. © 2009 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ccd.22047 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734143837</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>734143837</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3627-d55bbe6c15409d8d4d7fe54a9ccd8b102bdf2ace3041be4ee1022e8991e82a643</originalsourceid><addsrcrecordid>eNp1kMtOwzAURC0EoqWw4AeQd4hFWttxXkuUlhapAomHYGc5zk1ryKPYCdC_x6UFVqyuNffM2B6ETikZUkLYSKl8yBjh0R7q04AxL2Lh8_7uTBMe9tCRtS-EkCRkySHqOS0JKY37aDEpClCtxU2BVWdUV-kaF43BKwPvULe6XmADtoW6sdpit5R4uV6BUcum3OjGjUorbGSW6RbrUkuFpXGLNd7YWlw1OZTH6KCQpYWT3Rygx6vJQzrz5rfT6_Ry7ik_ZJGXB0GWQahowEmSxznPowICLhP3xTijhGV5waQCn3CaAQdwEoM4SSjETIbcH6Dzbe7KNG-de6CotFVQlrKGprMi8jnlfuxHjrzYkso01hooxMroSpq1oERsahXuTvFdq2PPdqldVkH-R-56dMBoC3zoEtb_J4k0Hf9EeluHdi19_jqkeRVh5EeBeLqZiruU3I9nKRFj_wtH0ZKo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>734143837</pqid></control><display><type>article</type><title>Effects of curcumin for preventing restenosis in a hypercholesterolemic rabbit iliac artery stent model</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Jang, Hyung-Suk ; Nam, Hye Yeong ; Kim, Jeong-Min ; Hahm, Dong-Hoon ; Nam, So Hee ; Kim, Koung Li ; Joo, Jae-Ryang ; Suh, Wonhee ; Park, Jong-Sang ; Kim, Duk Kyung ; Gwon, Hyeon-Cheol</creator><creatorcontrib>Jang, Hyung-Suk ; Nam, Hye Yeong ; Kim, Jeong-Min ; Hahm, Dong-Hoon ; Nam, So Hee ; Kim, Koung Li ; Joo, Jae-Ryang ; Suh, Wonhee ; Park, Jong-Sang ; Kim, Duk Kyung ; Gwon, Hyeon-Cheol</creatorcontrib><description>Objective:
To evaluate the efficacy of the curcumin‐coating stent (CCS) on the inhibition of restenosis in a rabbit iliac artery stent model.
Results:
Curcumin, pigment naturally acquired from the rhizome of the plant curcuma longa, is known to have antiproliferative, antimigratory, and anti‐inflammatory effects. However, it is still unclear that curcumin can inhibit neointimal proliferation of the injured vessel.
Methods:
Dose‐dependent inhibition of cell growth was observed over a dose range from 10 nM to 10 μM. CCS was prepared by a dip‐coating method (high‐dose: HD, low‐dose: LD). The release profile of the HD CCS showed that drug release persisted until day 21. Scanning electron microscopy of the CCS showed an intact surface of the stent even after expansion. To test the efficacy of CCS in vivo, LD CCS, HD CCS, and bare metal stents (BMS) were implanted in random order in one iliac artery (N = 30 arteries) of male New Zealand White rabbits (N = 15).
Results:
After 28 days, the LD and HD CCS groups had a 43% and 55% reduction in the neointimal area, compared with the BMS group (BMS 3.3 ± 1.0 mm2, LD 1.9 ± 0.8 mm2, and HD 0.9 ± 0.5 mm2, P < 0.05). There appeared to be no cytotoxicity related to curcumin at the indicated doses.
Conclusions:
Curcumin, a natural compound in the human diet, seems to be a safe and effective candidate drug for use in a drug‐eluting stent for the prevention of stent restenosis following angioplasty. © 2009 Wiley‐Liss, Inc.</description><identifier>ISSN: 1522-1946</identifier><identifier>EISSN: 1522-726X</identifier><identifier>DOI: 10.1002/ccd.22047</identifier><identifier>PMID: 19496118</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Angioplasty, Balloon - adverse effects ; Angioplasty, Balloon - instrumentation ; Animals ; Arterial Occlusive Diseases - etiology ; Arterial Occlusive Diseases - pathology ; Arterial Occlusive Diseases - prevention & control ; Cardiovascular Agents - administration & dosage ; Cell Movement - drug effects ; Cell Proliferation - drug effects ; Cells, Cultured ; Coated Materials, Biocompatible ; Constriction, Pathologic ; curcumin ; Curcumin - administration & dosage ; Disease Models, Animal ; Dose-Response Relationship, Drug ; drug-eluting stent ; Drug-Eluting Stents - adverse effects ; Hypercholesterolemia - complications ; Iliac Artery - drug effects ; Iliac Artery - pathology ; Male ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - metabolism ; Muscle, Smooth, Vascular - pathology ; Myocytes, Smooth Muscle - drug effects ; Myocytes, Smooth Muscle - metabolism ; Myocytes, Smooth Muscle - pathology ; Platelet-Derived Growth Factor - metabolism ; Prosthesis Design ; Proto-Oncogene Proteins c-sis ; Rabbits ; Rats ; Rats, Sprague-Dawley ; restenosis ; Surface Properties ; Time Factors</subject><ispartof>Catheterization and cardiovascular interventions, 2009-11, Vol.74 (6), p.881-888</ispartof><rights>Copyright © 2009 Wiley‐Liss, Inc.</rights><rights>Copyright 2009 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3627-d55bbe6c15409d8d4d7fe54a9ccd8b102bdf2ace3041be4ee1022e8991e82a643</citedby><cites>FETCH-LOGICAL-c3627-d55bbe6c15409d8d4d7fe54a9ccd8b102bdf2ace3041be4ee1022e8991e82a643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fccd.22047$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fccd.22047$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27926,27927,45576,45577</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19496118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jang, Hyung-Suk</creatorcontrib><creatorcontrib>Nam, Hye Yeong</creatorcontrib><creatorcontrib>Kim, Jeong-Min</creatorcontrib><creatorcontrib>Hahm, Dong-Hoon</creatorcontrib><creatorcontrib>Nam, So Hee</creatorcontrib><creatorcontrib>Kim, Koung Li</creatorcontrib><creatorcontrib>Joo, Jae-Ryang</creatorcontrib><creatorcontrib>Suh, Wonhee</creatorcontrib><creatorcontrib>Park, Jong-Sang</creatorcontrib><creatorcontrib>Kim, Duk Kyung</creatorcontrib><creatorcontrib>Gwon, Hyeon-Cheol</creatorcontrib><title>Effects of curcumin for preventing restenosis in a hypercholesterolemic rabbit iliac artery stent model</title><title>Catheterization and cardiovascular interventions</title><addtitle>Cathet. Cardiovasc. Intervent</addtitle><description>Objective:
To evaluate the efficacy of the curcumin‐coating stent (CCS) on the inhibition of restenosis in a rabbit iliac artery stent model.
Results:
Curcumin, pigment naturally acquired from the rhizome of the plant curcuma longa, is known to have antiproliferative, antimigratory, and anti‐inflammatory effects. However, it is still unclear that curcumin can inhibit neointimal proliferation of the injured vessel.
Methods:
Dose‐dependent inhibition of cell growth was observed over a dose range from 10 nM to 10 μM. CCS was prepared by a dip‐coating method (high‐dose: HD, low‐dose: LD). The release profile of the HD CCS showed that drug release persisted until day 21. Scanning electron microscopy of the CCS showed an intact surface of the stent even after expansion. To test the efficacy of CCS in vivo, LD CCS, HD CCS, and bare metal stents (BMS) were implanted in random order in one iliac artery (N = 30 arteries) of male New Zealand White rabbits (N = 15).
Results:
After 28 days, the LD and HD CCS groups had a 43% and 55% reduction in the neointimal area, compared with the BMS group (BMS 3.3 ± 1.0 mm2, LD 1.9 ± 0.8 mm2, and HD 0.9 ± 0.5 mm2, P < 0.05). There appeared to be no cytotoxicity related to curcumin at the indicated doses.
Conclusions:
Curcumin, a natural compound in the human diet, seems to be a safe and effective candidate drug for use in a drug‐eluting stent for the prevention of stent restenosis following angioplasty. © 2009 Wiley‐Liss, Inc.</description><subject>Angioplasty, Balloon - adverse effects</subject><subject>Angioplasty, Balloon - instrumentation</subject><subject>Animals</subject><subject>Arterial Occlusive Diseases - etiology</subject><subject>Arterial Occlusive Diseases - pathology</subject><subject>Arterial Occlusive Diseases - prevention & control</subject><subject>Cardiovascular Agents - administration & dosage</subject><subject>Cell Movement - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Cells, Cultured</subject><subject>Coated Materials, Biocompatible</subject><subject>Constriction, Pathologic</subject><subject>curcumin</subject><subject>Curcumin - administration & dosage</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>drug-eluting stent</subject><subject>Drug-Eluting Stents - adverse effects</subject><subject>Hypercholesterolemia - complications</subject><subject>Iliac Artery - drug effects</subject><subject>Iliac Artery - pathology</subject><subject>Male</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - metabolism</subject><subject>Muscle, Smooth, Vascular - pathology</subject><subject>Myocytes, Smooth Muscle - drug effects</subject><subject>Myocytes, Smooth Muscle - metabolism</subject><subject>Myocytes, Smooth Muscle - pathology</subject><subject>Platelet-Derived Growth Factor - metabolism</subject><subject>Prosthesis Design</subject><subject>Proto-Oncogene Proteins c-sis</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>restenosis</subject><subject>Surface Properties</subject><subject>Time Factors</subject><issn>1522-1946</issn><issn>1522-726X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtOwzAURC0EoqWw4AeQd4hFWttxXkuUlhapAomHYGc5zk1ryKPYCdC_x6UFVqyuNffM2B6ETikZUkLYSKl8yBjh0R7q04AxL2Lh8_7uTBMe9tCRtS-EkCRkySHqOS0JKY37aDEpClCtxU2BVWdUV-kaF43BKwPvULe6XmADtoW6sdpit5R4uV6BUcum3OjGjUorbGSW6RbrUkuFpXGLNd7YWlw1OZTH6KCQpYWT3Rygx6vJQzrz5rfT6_Ry7ik_ZJGXB0GWQahowEmSxznPowICLhP3xTijhGV5waQCn3CaAQdwEoM4SSjETIbcH6Dzbe7KNG-de6CotFVQlrKGprMi8jnlfuxHjrzYkso01hooxMroSpq1oERsahXuTvFdq2PPdqldVkH-R-56dMBoC3zoEtb_J4k0Hf9EeluHdi19_jqkeRVh5EeBeLqZiruU3I9nKRFj_wtH0ZKo</recordid><startdate>20091115</startdate><enddate>20091115</enddate><creator>Jang, Hyung-Suk</creator><creator>Nam, Hye Yeong</creator><creator>Kim, Jeong-Min</creator><creator>Hahm, Dong-Hoon</creator><creator>Nam, So Hee</creator><creator>Kim, Koung Li</creator><creator>Joo, Jae-Ryang</creator><creator>Suh, Wonhee</creator><creator>Park, Jong-Sang</creator><creator>Kim, Duk Kyung</creator><creator>Gwon, Hyeon-Cheol</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091115</creationdate><title>Effects of curcumin for preventing restenosis in a hypercholesterolemic rabbit iliac artery stent model</title><author>Jang, Hyung-Suk ; Nam, Hye Yeong ; Kim, Jeong-Min ; Hahm, Dong-Hoon ; Nam, So Hee ; Kim, Koung Li ; Joo, Jae-Ryang ; Suh, Wonhee ; Park, Jong-Sang ; Kim, Duk Kyung ; Gwon, Hyeon-Cheol</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3627-d55bbe6c15409d8d4d7fe54a9ccd8b102bdf2ace3041be4ee1022e8991e82a643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Angioplasty, Balloon - adverse effects</topic><topic>Angioplasty, Balloon - instrumentation</topic><topic>Animals</topic><topic>Arterial Occlusive Diseases - etiology</topic><topic>Arterial Occlusive Diseases - pathology</topic><topic>Arterial Occlusive Diseases - prevention & control</topic><topic>Cardiovascular Agents - administration & dosage</topic><topic>Cell Movement - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Cells, Cultured</topic><topic>Coated Materials, Biocompatible</topic><topic>Constriction, Pathologic</topic><topic>curcumin</topic><topic>Curcumin - administration & dosage</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>drug-eluting stent</topic><topic>Drug-Eluting Stents - adverse effects</topic><topic>Hypercholesterolemia - complications</topic><topic>Iliac Artery - drug effects</topic><topic>Iliac Artery - pathology</topic><topic>Male</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - metabolism</topic><topic>Muscle, Smooth, Vascular - pathology</topic><topic>Myocytes, Smooth Muscle - drug effects</topic><topic>Myocytes, Smooth Muscle - metabolism</topic><topic>Myocytes, Smooth Muscle - pathology</topic><topic>Platelet-Derived Growth Factor - metabolism</topic><topic>Prosthesis Design</topic><topic>Proto-Oncogene Proteins c-sis</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>restenosis</topic><topic>Surface Properties</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jang, Hyung-Suk</creatorcontrib><creatorcontrib>Nam, Hye Yeong</creatorcontrib><creatorcontrib>Kim, Jeong-Min</creatorcontrib><creatorcontrib>Hahm, Dong-Hoon</creatorcontrib><creatorcontrib>Nam, So Hee</creatorcontrib><creatorcontrib>Kim, Koung Li</creatorcontrib><creatorcontrib>Joo, Jae-Ryang</creatorcontrib><creatorcontrib>Suh, Wonhee</creatorcontrib><creatorcontrib>Park, Jong-Sang</creatorcontrib><creatorcontrib>Kim, Duk Kyung</creatorcontrib><creatorcontrib>Gwon, Hyeon-Cheol</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Catheterization and cardiovascular interventions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jang, Hyung-Suk</au><au>Nam, Hye Yeong</au><au>Kim, Jeong-Min</au><au>Hahm, Dong-Hoon</au><au>Nam, So Hee</au><au>Kim, Koung Li</au><au>Joo, Jae-Ryang</au><au>Suh, Wonhee</au><au>Park, Jong-Sang</au><au>Kim, Duk Kyung</au><au>Gwon, Hyeon-Cheol</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of curcumin for preventing restenosis in a hypercholesterolemic rabbit iliac artery stent model</atitle><jtitle>Catheterization and cardiovascular interventions</jtitle><addtitle>Cathet. Cardiovasc. Intervent</addtitle><date>2009-11-15</date><risdate>2009</risdate><volume>74</volume><issue>6</issue><spage>881</spage><epage>888</epage><pages>881-888</pages><issn>1522-1946</issn><eissn>1522-726X</eissn><abstract>Objective:
To evaluate the efficacy of the curcumin‐coating stent (CCS) on the inhibition of restenosis in a rabbit iliac artery stent model.
Results:
Curcumin, pigment naturally acquired from the rhizome of the plant curcuma longa, is known to have antiproliferative, antimigratory, and anti‐inflammatory effects. However, it is still unclear that curcumin can inhibit neointimal proliferation of the injured vessel.
Methods:
Dose‐dependent inhibition of cell growth was observed over a dose range from 10 nM to 10 μM. CCS was prepared by a dip‐coating method (high‐dose: HD, low‐dose: LD). The release profile of the HD CCS showed that drug release persisted until day 21. Scanning electron microscopy of the CCS showed an intact surface of the stent even after expansion. To test the efficacy of CCS in vivo, LD CCS, HD CCS, and bare metal stents (BMS) were implanted in random order in one iliac artery (N = 30 arteries) of male New Zealand White rabbits (N = 15).
Results:
After 28 days, the LD and HD CCS groups had a 43% and 55% reduction in the neointimal area, compared with the BMS group (BMS 3.3 ± 1.0 mm2, LD 1.9 ± 0.8 mm2, and HD 0.9 ± 0.5 mm2, P < 0.05). There appeared to be no cytotoxicity related to curcumin at the indicated doses.
Conclusions:
Curcumin, a natural compound in the human diet, seems to be a safe and effective candidate drug for use in a drug‐eluting stent for the prevention of stent restenosis following angioplasty. © 2009 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19496118</pmid><doi>10.1002/ccd.22047</doi><tpages>8</tpages></addata></record> |
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| ispartof | Catheterization and cardiovascular interventions, 2009-11, Vol.74 (6), p.881-888 |
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| subjects | Angioplasty, Balloon - adverse effects Angioplasty, Balloon - instrumentation Animals Arterial Occlusive Diseases - etiology Arterial Occlusive Diseases - pathology Arterial Occlusive Diseases - prevention & control Cardiovascular Agents - administration & dosage Cell Movement - drug effects Cell Proliferation - drug effects Cells, Cultured Coated Materials, Biocompatible Constriction, Pathologic curcumin Curcumin - administration & dosage Disease Models, Animal Dose-Response Relationship, Drug drug-eluting stent Drug-Eluting Stents - adverse effects Hypercholesterolemia - complications Iliac Artery - drug effects Iliac Artery - pathology Male Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Platelet-Derived Growth Factor - metabolism Prosthesis Design Proto-Oncogene Proteins c-sis Rabbits Rats Rats, Sprague-Dawley restenosis Surface Properties Time Factors |
| title | Effects of curcumin for preventing restenosis in a hypercholesterolemic rabbit iliac artery stent model |
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