Magnetic resonance imaging of renal involvement in genetically studied patients with tuberous sclerosis complex
Abstract Purpose To evaluate renal involvement in tuberous sclerosis complex (TSC). Materials and methods A series of 24 TSC patients (19 with genetically demonstrated disease), underwent abdominal 1.0-T MR imaging with axial/coronal T1- and T2-weighted scans, with/without fat saturation. We looked...
Gespeichert in:
| Veröffentlicht in: | European journal of radiology 2009-11, Vol.72 (2), p.335-341 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 341 |
|---|---|
| container_issue | 2 |
| container_start_page | 335 |
| container_title | European journal of radiology |
| container_volume | 72 |
| creator | Pompili, Giovanni Zirpoli, Salvatore Sala, Chiara Flor, Nicola Alfano, Rosa Maria Volpi, Angela Brancaccio, Diego Sardanelli, Francesco Cornalba, Gianpaolo |
| description | Abstract Purpose To evaluate renal involvement in tuberous sclerosis complex (TSC). Materials and methods A series of 24 TSC patients (19 with genetically demonstrated disease), underwent abdominal 1.0-T MR imaging with axial/coronal T1- and T2-weighted scans, with/without fat saturation. We looked for angyomiolipomas (AMLs) and cysts in 47 kidneys of 24 patients. We evaluated the percentage of parenchymal involvement by manual contouring on the coronal scans in 39 kidneys of 20 patients. Results We detected AMLs in 15/24 (63%) patients and in 27/47 (57%) kidneys, cysts in 14/24 (58%) and in 26/47 (55%); respectively. AMLs were found in 2/4 TSC1 and in 11/15 TSC2 patients, cysts were found in 2/4 TSC1 and in 9/15 TSC2 patients. The global renal involvement ranged from 0 to 32% (median, 18%) in TSC1 and from 0 to 100% (median, 39%) in TSC2 patients. A fair correlation ( r = .464) was found between patient’s age and renal involvement, a good correlation ( r = 0.655) between renal involvement and creatinine clearance. Conclusion Renal parenchyma of TSC patients can be evaluated with MR imaging. A detectable renal involvement was found in 83% of patients, higher in TSC2 than in TSC1. Renal function seems to correlate with renal involvement quantified with MR imaging. |
| doi_str_mv | 10.1016/j.ejrad.2008.07.046 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734142730</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0720048X0800435X</els_id><sourcerecordid>734142730</sourcerecordid><originalsourceid>FETCH-LOGICAL-c443t-a722413f76ed9577a4730522e2605bc83fe5e3311ddc59b99a7d4422671bcf133</originalsourceid><addsrcrecordid>eNqFkk2LFDEQhoMo7rj6CwTJRTx1m6_udB8UlsUvWPGgwt5COqke02a6x6R7dP691TuDghdPVSTvW7w8VYQ85azkjNcvhxKGZH0pGGtKpkum6ntkwxstCq2Fvk82TAtWMNXcXpBHOQ-MsUq14iG54E0jK86bDZk-2u0Ic3A0QZ5GOzqgYWe3YdzSqcfH0UYaxsMUD7CDccaebuHOYWM80jwvPoCnezsH_M70Z5i_0XnpIE1LptlFbHLI1E27fYRfj8mD3sYMT871knx9--bL9fvi5tO7D9dXN4VTSs6F1UIoLntdg28rra3SklVCgKhZ1blG9lCBlJx776q2a1urvVJC1Jp3rudSXpIXp7n7NP1YIM9mF7KDGO0IGMxoqbgSOBSV8qR0GDQn6M0-IYF0NJyZFbQZzB1os4I2TBsEja5n5_lLtwP_13Mmi4LnZ4HNiKpPiDbkPzohRKVwVah7ddIB0jgESCY7JOnAhwRuNn4K_wny-h-_i2Fct_MdjpCHaUm4wmy4ycIw83m9ifUkWINFVrfyN6pvs5Y</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>734142730</pqid></control><display><type>article</type><title>Magnetic resonance imaging of renal involvement in genetically studied patients with tuberous sclerosis complex</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Pompili, Giovanni ; Zirpoli, Salvatore ; Sala, Chiara ; Flor, Nicola ; Alfano, Rosa Maria ; Volpi, Angela ; Brancaccio, Diego ; Sardanelli, Francesco ; Cornalba, Gianpaolo</creator><creatorcontrib>Pompili, Giovanni ; Zirpoli, Salvatore ; Sala, Chiara ; Flor, Nicola ; Alfano, Rosa Maria ; Volpi, Angela ; Brancaccio, Diego ; Sardanelli, Francesco ; Cornalba, Gianpaolo</creatorcontrib><description>Abstract Purpose To evaluate renal involvement in tuberous sclerosis complex (TSC). Materials and methods A series of 24 TSC patients (19 with genetically demonstrated disease), underwent abdominal 1.0-T MR imaging with axial/coronal T1- and T2-weighted scans, with/without fat saturation. We looked for angyomiolipomas (AMLs) and cysts in 47 kidneys of 24 patients. We evaluated the percentage of parenchymal involvement by manual contouring on the coronal scans in 39 kidneys of 20 patients. Results We detected AMLs in 15/24 (63%) patients and in 27/47 (57%) kidneys, cysts in 14/24 (58%) and in 26/47 (55%); respectively. AMLs were found in 2/4 TSC1 and in 11/15 TSC2 patients, cysts were found in 2/4 TSC1 and in 9/15 TSC2 patients. The global renal involvement ranged from 0 to 32% (median, 18%) in TSC1 and from 0 to 100% (median, 39%) in TSC2 patients. A fair correlation ( r = .464) was found between patient’s age and renal involvement, a good correlation ( r = 0.655) between renal involvement and creatinine clearance. Conclusion Renal parenchyma of TSC patients can be evaluated with MR imaging. A detectable renal involvement was found in 83% of patients, higher in TSC2 than in TSC1. Renal function seems to correlate with renal involvement quantified with MR imaging.</description><identifier>ISSN: 0720-048X</identifier><identifier>EISSN: 1872-7727</identifier><identifier>DOI: 10.1016/j.ejrad.2008.07.046</identifier><identifier>PMID: 18835118</identifier><identifier>CODEN: EJRADR</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Adolescent ; Adult ; Angiomiolipoma ; Angiomyolipoma - complications ; Angiomyolipoma - diagnosis ; Angiomyolipoma - genetics ; Biological and medical sciences ; Child ; Child, Preschool ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Kidney ; Liver Neoplasms - complications ; Liver Neoplasms - diagnosis ; Liver Neoplasms - genetics ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Middle Aged ; MRI ; Neurology ; Radiology ; Tuberous sclerosis ; Tuberous Sclerosis - complications ; Tuberous Sclerosis - diagnosis ; Tuberous Sclerosis - genetics ; Tumors of the nervous system. Phacomatoses ; Young Adult</subject><ispartof>European journal of radiology, 2009-11, Vol.72 (2), p.335-341</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2008 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-a722413f76ed9577a4730522e2605bc83fe5e3311ddc59b99a7d4422671bcf133</citedby><cites>FETCH-LOGICAL-c443t-a722413f76ed9577a4730522e2605bc83fe5e3311ddc59b99a7d4422671bcf133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejrad.2008.07.046$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22254872$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18835118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pompili, Giovanni</creatorcontrib><creatorcontrib>Zirpoli, Salvatore</creatorcontrib><creatorcontrib>Sala, Chiara</creatorcontrib><creatorcontrib>Flor, Nicola</creatorcontrib><creatorcontrib>Alfano, Rosa Maria</creatorcontrib><creatorcontrib>Volpi, Angela</creatorcontrib><creatorcontrib>Brancaccio, Diego</creatorcontrib><creatorcontrib>Sardanelli, Francesco</creatorcontrib><creatorcontrib>Cornalba, Gianpaolo</creatorcontrib><title>Magnetic resonance imaging of renal involvement in genetically studied patients with tuberous sclerosis complex</title><title>European journal of radiology</title><addtitle>Eur J Radiol</addtitle><description>Abstract Purpose To evaluate renal involvement in tuberous sclerosis complex (TSC). Materials and methods A series of 24 TSC patients (19 with genetically demonstrated disease), underwent abdominal 1.0-T MR imaging with axial/coronal T1- and T2-weighted scans, with/without fat saturation. We looked for angyomiolipomas (AMLs) and cysts in 47 kidneys of 24 patients. We evaluated the percentage of parenchymal involvement by manual contouring on the coronal scans in 39 kidneys of 20 patients. Results We detected AMLs in 15/24 (63%) patients and in 27/47 (57%) kidneys, cysts in 14/24 (58%) and in 26/47 (55%); respectively. AMLs were found in 2/4 TSC1 and in 11/15 TSC2 patients, cysts were found in 2/4 TSC1 and in 9/15 TSC2 patients. The global renal involvement ranged from 0 to 32% (median, 18%) in TSC1 and from 0 to 100% (median, 39%) in TSC2 patients. A fair correlation ( r = .464) was found between patient’s age and renal involvement, a good correlation ( r = 0.655) between renal involvement and creatinine clearance. Conclusion Renal parenchyma of TSC patients can be evaluated with MR imaging. A detectable renal involvement was found in 83% of patients, higher in TSC2 than in TSC1. Renal function seems to correlate with renal involvement quantified with MR imaging.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Angiomiolipoma</subject><subject>Angiomyolipoma - complications</subject><subject>Angiomyolipoma - diagnosis</subject><subject>Angiomyolipoma - genetics</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Kidney</subject><subject>Liver Neoplasms - complications</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - genetics</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>Neurology</subject><subject>Radiology</subject><subject>Tuberous sclerosis</subject><subject>Tuberous Sclerosis - complications</subject><subject>Tuberous Sclerosis - diagnosis</subject><subject>Tuberous Sclerosis - genetics</subject><subject>Tumors of the nervous system. Phacomatoses</subject><subject>Young Adult</subject><issn>0720-048X</issn><issn>1872-7727</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2LFDEQhoMo7rj6CwTJRTx1m6_udB8UlsUvWPGgwt5COqke02a6x6R7dP691TuDghdPVSTvW7w8VYQ85azkjNcvhxKGZH0pGGtKpkum6ntkwxstCq2Fvk82TAtWMNXcXpBHOQ-MsUq14iG54E0jK86bDZk-2u0Ic3A0QZ5GOzqgYWe3YdzSqcfH0UYaxsMUD7CDccaebuHOYWM80jwvPoCnezsH_M70Z5i_0XnpIE1LptlFbHLI1E27fYRfj8mD3sYMT871knx9--bL9fvi5tO7D9dXN4VTSs6F1UIoLntdg28rra3SklVCgKhZ1blG9lCBlJx776q2a1urvVJC1Jp3rudSXpIXp7n7NP1YIM9mF7KDGO0IGMxoqbgSOBSV8qR0GDQn6M0-IYF0NJyZFbQZzB1os4I2TBsEja5n5_lLtwP_13Mmi4LnZ4HNiKpPiDbkPzohRKVwVah7ddIB0jgESCY7JOnAhwRuNn4K_wny-h-_i2Fct_MdjpCHaUm4wmy4ycIw83m9ifUkWINFVrfyN6pvs5Y</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Pompili, Giovanni</creator><creator>Zirpoli, Salvatore</creator><creator>Sala, Chiara</creator><creator>Flor, Nicola</creator><creator>Alfano, Rosa Maria</creator><creator>Volpi, Angela</creator><creator>Brancaccio, Diego</creator><creator>Sardanelli, Francesco</creator><creator>Cornalba, Gianpaolo</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Magnetic resonance imaging of renal involvement in genetically studied patients with tuberous sclerosis complex</title><author>Pompili, Giovanni ; Zirpoli, Salvatore ; Sala, Chiara ; Flor, Nicola ; Alfano, Rosa Maria ; Volpi, Angela ; Brancaccio, Diego ; Sardanelli, Francesco ; Cornalba, Gianpaolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-a722413f76ed9577a4730522e2605bc83fe5e3311ddc59b99a7d4422671bcf133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Angiomiolipoma</topic><topic>Angiomyolipoma - complications</topic><topic>Angiomyolipoma - diagnosis</topic><topic>Angiomyolipoma - genetics</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Kidney</topic><topic>Liver Neoplasms - complications</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - genetics</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>Neurology</topic><topic>Radiology</topic><topic>Tuberous sclerosis</topic><topic>Tuberous Sclerosis - complications</topic><topic>Tuberous Sclerosis - diagnosis</topic><topic>Tuberous Sclerosis - genetics</topic><topic>Tumors of the nervous system. Phacomatoses</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pompili, Giovanni</creatorcontrib><creatorcontrib>Zirpoli, Salvatore</creatorcontrib><creatorcontrib>Sala, Chiara</creatorcontrib><creatorcontrib>Flor, Nicola</creatorcontrib><creatorcontrib>Alfano, Rosa Maria</creatorcontrib><creatorcontrib>Volpi, Angela</creatorcontrib><creatorcontrib>Brancaccio, Diego</creatorcontrib><creatorcontrib>Sardanelli, Francesco</creatorcontrib><creatorcontrib>Cornalba, Gianpaolo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pompili, Giovanni</au><au>Zirpoli, Salvatore</au><au>Sala, Chiara</au><au>Flor, Nicola</au><au>Alfano, Rosa Maria</au><au>Volpi, Angela</au><au>Brancaccio, Diego</au><au>Sardanelli, Francesco</au><au>Cornalba, Gianpaolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic resonance imaging of renal involvement in genetically studied patients with tuberous sclerosis complex</atitle><jtitle>European journal of radiology</jtitle><addtitle>Eur J Radiol</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>72</volume><issue>2</issue><spage>335</spage><epage>341</epage><pages>335-341</pages><issn>0720-048X</issn><eissn>1872-7727</eissn><coden>EJRADR</coden><abstract>Abstract Purpose To evaluate renal involvement in tuberous sclerosis complex (TSC). Materials and methods A series of 24 TSC patients (19 with genetically demonstrated disease), underwent abdominal 1.0-T MR imaging with axial/coronal T1- and T2-weighted scans, with/without fat saturation. We looked for angyomiolipomas (AMLs) and cysts in 47 kidneys of 24 patients. We evaluated the percentage of parenchymal involvement by manual contouring on the coronal scans in 39 kidneys of 20 patients. Results We detected AMLs in 15/24 (63%) patients and in 27/47 (57%) kidneys, cysts in 14/24 (58%) and in 26/47 (55%); respectively. AMLs were found in 2/4 TSC1 and in 11/15 TSC2 patients, cysts were found in 2/4 TSC1 and in 9/15 TSC2 patients. The global renal involvement ranged from 0 to 32% (median, 18%) in TSC1 and from 0 to 100% (median, 39%) in TSC2 patients. A fair correlation ( r = .464) was found between patient’s age and renal involvement, a good correlation ( r = 0.655) between renal involvement and creatinine clearance. Conclusion Renal parenchyma of TSC patients can be evaluated with MR imaging. A detectable renal involvement was found in 83% of patients, higher in TSC2 than in TSC1. Renal function seems to correlate with renal involvement quantified with MR imaging.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>18835118</pmid><doi>10.1016/j.ejrad.2008.07.046</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0720-048X |
| ispartof | European journal of radiology, 2009-11, Vol.72 (2), p.335-341 |
| issn | 0720-048X 1872-7727 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734142730 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adolescent Adult Angiomiolipoma Angiomyolipoma - complications Angiomyolipoma - diagnosis Angiomyolipoma - genetics Biological and medical sciences Child Child, Preschool Female Humans Investigative techniques, diagnostic techniques (general aspects) Kidney Liver Neoplasms - complications Liver Neoplasms - diagnosis Liver Neoplasms - genetics Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged MRI Neurology Radiology Tuberous sclerosis Tuberous Sclerosis - complications Tuberous Sclerosis - diagnosis Tuberous Sclerosis - genetics Tumors of the nervous system. Phacomatoses Young Adult |
| title | Magnetic resonance imaging of renal involvement in genetically studied patients with tuberous sclerosis complex |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T10%3A16%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Magnetic%20resonance%20imaging%20of%20renal%20involvement%20in%20genetically%20studied%20patients%20with%20tuberous%20sclerosis%20complex&rft.jtitle=European%20journal%20of%20radiology&rft.au=Pompili,%20Giovanni&rft.date=2009-11-01&rft.volume=72&rft.issue=2&rft.spage=335&rft.epage=341&rft.pages=335-341&rft.issn=0720-048X&rft.eissn=1872-7727&rft.coden=EJRADR&rft_id=info:doi/10.1016/j.ejrad.2008.07.046&rft_dat=%3Cproquest_cross%3E734142730%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=734142730&rft_id=info:pmid/18835118&rft_els_id=1_s2_0_S0720048X0800435X&rfr_iscdi=true |