Variations in ventral root axon morphology and locomotor behavior components across different inbred strains of mice
Abstract Locomotion is a complex behavior affected by many different brain- and spinal cord systems, as well as by variations in the peripheral nervous system. Recently, we found increased gene expression for EphA4 , a gene intricately involved in motor neuron development, between high-active parent...
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description | Abstract Locomotion is a complex behavior affected by many different brain- and spinal cord systems, as well as by variations in the peripheral nervous system. Recently, we found increased gene expression for EphA4 , a gene intricately involved in motor neuron development, between high-active parental strain C57BL/6J and the low-active chromosome substitution strain 1 (CSS1). CSS1 mice carry chromosome 1 from A/J mice in a C57BL/6J genetic background, allowing localization of quantitative trait loci (QTL) on chromosome 1. To find out whether differences in motor neuron anatomy, possibly related to the changes in EphA4 expression, are involved in the motor activity differences observed in these strains, motor performance in various behavioral paradigms and anatomical differences in the ventral roots were investigated. To correlate the behavioral profiles to the spinal motor neuron morphology, not only CSS1 and its parental strains C57BL/6J (host) and A/J (donor) were examined, but also a set of other mouse inbred strains (AKR/J, 129×1/SvJ and DBA/2J). Significant differences were found between inbred strains on home cage motor activity levels, the beam balance test, grip test performance, and on alternating versus synchronous hind limb movement (hind limb hopping). Also, considerable differences were found in spinal motor neuron morphology, with A/J and CSS1 showing smaller, possibly less developed, motor neuron axons compared to all other inbred strains. For CSS1 and C57BL/6J, only genetically different for chromosome 1, a correlation was found between motor activity levels, synchronous hind limb movement and neuro-anatomical differences in spinal motor neurons. Inclusion of the other inbred strains, however, did not show this direct correlation. These data verifies the complex nature of the mammalian motor system that may be further dissected using genetic mapping populations derived from these inbred strains. |
doi_str_mv | 10.1016/j.neuroscience.2009.09.008 |
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Recently, we found increased gene expression for EphA4 , a gene intricately involved in motor neuron development, between high-active parental strain C57BL/6J and the low-active chromosome substitution strain 1 (CSS1). CSS1 mice carry chromosome 1 from A/J mice in a C57BL/6J genetic background, allowing localization of quantitative trait loci (QTL) on chromosome 1. To find out whether differences in motor neuron anatomy, possibly related to the changes in EphA4 expression, are involved in the motor activity differences observed in these strains, motor performance in various behavioral paradigms and anatomical differences in the ventral roots were investigated. To correlate the behavioral profiles to the spinal motor neuron morphology, not only CSS1 and its parental strains C57BL/6J (host) and A/J (donor) were examined, but also a set of other mouse inbred strains (AKR/J, 129×1/SvJ and DBA/2J). Significant differences were found between inbred strains on home cage motor activity levels, the beam balance test, grip test performance, and on alternating versus synchronous hind limb movement (hind limb hopping). Also, considerable differences were found in spinal motor neuron morphology, with A/J and CSS1 showing smaller, possibly less developed, motor neuron axons compared to all other inbred strains. For CSS1 and C57BL/6J, only genetically different for chromosome 1, a correlation was found between motor activity levels, synchronous hind limb movement and neuro-anatomical differences in spinal motor neurons. Inclusion of the other inbred strains, however, did not show this direct correlation. These data verifies the complex nature of the mammalian motor system that may be further dissected using genetic mapping populations derived from these inbred strains.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2009.09.008</identifier><identifier>PMID: 19778584</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Animals ; Axons - ultrastructure ; Biological and medical sciences ; chromosome substitution strain ; Fundamental and applied biological sciences. Psychology ; home cage ; Male ; Mice ; Mice, Inbred Strains ; Motor Activity - genetics ; Motor Activity - physiology ; motor activity levels ; motor neuron anatomy ; Motor Neurons - ultrastructure ; mouse ; Neurology ; Species Specificity ; Spinal Nerve Roots - ultrastructure ; ventral roots ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience, 2009-12, Vol.164 (4), p.1477-1483</ispartof><rights>IBRO</rights><rights>2009 IBRO</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-1efca81b64141b09027d39ee8e182aba4625b5c47c8be3f7decc044d13fb5343</citedby><cites>FETCH-LOGICAL-c526t-1efca81b64141b09027d39ee8e182aba4625b5c47c8be3f7decc044d13fb5343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuroscience.2009.09.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22195498$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19778584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Mooij-van Malsen, J.G</creatorcontrib><creatorcontrib>Yu, K.L</creatorcontrib><creatorcontrib>Veldman, H</creatorcontrib><creatorcontrib>Oppelaar, H</creatorcontrib><creatorcontrib>van den Berg, L.H</creatorcontrib><creatorcontrib>Olivier, B</creatorcontrib><creatorcontrib>Kas, M.J.H</creatorcontrib><title>Variations in ventral root axon morphology and locomotor behavior components across different inbred strains of mice</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Abstract Locomotion is a complex behavior affected by many different brain- and spinal cord systems, as well as by variations in the peripheral nervous system. Recently, we found increased gene expression for EphA4 , a gene intricately involved in motor neuron development, between high-active parental strain C57BL/6J and the low-active chromosome substitution strain 1 (CSS1). CSS1 mice carry chromosome 1 from A/J mice in a C57BL/6J genetic background, allowing localization of quantitative trait loci (QTL) on chromosome 1. To find out whether differences in motor neuron anatomy, possibly related to the changes in EphA4 expression, are involved in the motor activity differences observed in these strains, motor performance in various behavioral paradigms and anatomical differences in the ventral roots were investigated. To correlate the behavioral profiles to the spinal motor neuron morphology, not only CSS1 and its parental strains C57BL/6J (host) and A/J (donor) were examined, but also a set of other mouse inbred strains (AKR/J, 129×1/SvJ and DBA/2J). Significant differences were found between inbred strains on home cage motor activity levels, the beam balance test, grip test performance, and on alternating versus synchronous hind limb movement (hind limb hopping). Also, considerable differences were found in spinal motor neuron morphology, with A/J and CSS1 showing smaller, possibly less developed, motor neuron axons compared to all other inbred strains. For CSS1 and C57BL/6J, only genetically different for chromosome 1, a correlation was found between motor activity levels, synchronous hind limb movement and neuro-anatomical differences in spinal motor neurons. Inclusion of the other inbred strains, however, did not show this direct correlation. These data verifies the complex nature of the mammalian motor system that may be further dissected using genetic mapping populations derived from these inbred strains.</description><subject>Animals</subject><subject>Axons - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>chromosome substitution strain</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>home cage</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Motor Activity - genetics</subject><subject>Motor Activity - physiology</subject><subject>motor activity levels</subject><subject>motor neuron anatomy</subject><subject>Motor Neurons - ultrastructure</subject><subject>mouse</subject><subject>Neurology</subject><subject>Species Specificity</subject><subject>Spinal Nerve Roots - ultrastructure</subject><subject>ventral roots</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk2LFDEQhoMo7uzqX5AgqKce89md9iDIun7AggcXryFJV7sZu5Mx6R6cf2_aaVQ8yIaChOKpt4p6g9BTSraU0PrlbhtgTjE7D8HBlhHSbpcg6h7aUNXwqpFC3EcbwkldCcnYGTrPeUfKkYI_RGe0bRolldig6YtJ3kw-hox9wAcIUzIDTjFO2PyIAY8x7W_jEL8esQkdHqKLY5xiwhZuzcGXR0nsYyiFGRtXxsq4830PqWSKpE3Q4VxEfekQezx6B4_Qg94MGR6v9wW6eXd1c_mhuv70_uPlm-vKSVZPFYXeGUVtLaiglrSENR1vARRQxYw1ombSSicapyzwvunAOSJER3lvJRf8Ar04ye5T_D5DnvTos4NhMAHinHXDizCjtC3k8_-SBSKS0foOIBFKtYviqxP4ayMJer1PfjTpqCnRi4t6p_92US8u6iWIKsVP1i6zHaH7U7raVoBnK2CyM0OfTHA-_-YYo60U7SL09sRB2fLBQ9Jru84ncJPuor_bPK__kXGDD750_gZHyLs4p1B81FRnpon-vPy75dsVy6goI_OfIcXZgQ</recordid><startdate>20091229</startdate><enddate>20091229</enddate><creator>de Mooij-van Malsen, J.G</creator><creator>Yu, K.L</creator><creator>Veldman, H</creator><creator>Oppelaar, H</creator><creator>van den Berg, L.H</creator><creator>Olivier, B</creator><creator>Kas, M.J.H</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20091229</creationdate><title>Variations in ventral root axon morphology and locomotor behavior components across different inbred strains of mice</title><author>de Mooij-van Malsen, J.G ; Yu, K.L ; Veldman, H ; Oppelaar, H ; van den Berg, L.H ; Olivier, B ; Kas, M.J.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-1efca81b64141b09027d39ee8e182aba4625b5c47c8be3f7decc044d13fb5343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Axons - ultrastructure</topic><topic>Biological and medical sciences</topic><topic>chromosome substitution strain</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>home cage</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Motor Activity - genetics</topic><topic>Motor Activity - physiology</topic><topic>motor activity levels</topic><topic>motor neuron anatomy</topic><topic>Motor Neurons - ultrastructure</topic><topic>mouse</topic><topic>Neurology</topic><topic>Species Specificity</topic><topic>Spinal Nerve Roots - ultrastructure</topic><topic>ventral roots</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Mooij-van Malsen, J.G</creatorcontrib><creatorcontrib>Yu, K.L</creatorcontrib><creatorcontrib>Veldman, H</creatorcontrib><creatorcontrib>Oppelaar, H</creatorcontrib><creatorcontrib>van den Berg, L.H</creatorcontrib><creatorcontrib>Olivier, B</creatorcontrib><creatorcontrib>Kas, M.J.H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Mooij-van Malsen, J.G</au><au>Yu, K.L</au><au>Veldman, H</au><au>Oppelaar, H</au><au>van den Berg, L.H</au><au>Olivier, B</au><au>Kas, M.J.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variations in ventral root axon morphology and locomotor behavior components across different inbred strains of mice</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2009-12-29</date><risdate>2009</risdate><volume>164</volume><issue>4</issue><spage>1477</spage><epage>1483</epage><pages>1477-1483</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Abstract Locomotion is a complex behavior affected by many different brain- and spinal cord systems, as well as by variations in the peripheral nervous system. Recently, we found increased gene expression for EphA4 , a gene intricately involved in motor neuron development, between high-active parental strain C57BL/6J and the low-active chromosome substitution strain 1 (CSS1). CSS1 mice carry chromosome 1 from A/J mice in a C57BL/6J genetic background, allowing localization of quantitative trait loci (QTL) on chromosome 1. To find out whether differences in motor neuron anatomy, possibly related to the changes in EphA4 expression, are involved in the motor activity differences observed in these strains, motor performance in various behavioral paradigms and anatomical differences in the ventral roots were investigated. To correlate the behavioral profiles to the spinal motor neuron morphology, not only CSS1 and its parental strains C57BL/6J (host) and A/J (donor) were examined, but also a set of other mouse inbred strains (AKR/J, 129×1/SvJ and DBA/2J). Significant differences were found between inbred strains on home cage motor activity levels, the beam balance test, grip test performance, and on alternating versus synchronous hind limb movement (hind limb hopping). Also, considerable differences were found in spinal motor neuron morphology, with A/J and CSS1 showing smaller, possibly less developed, motor neuron axons compared to all other inbred strains. For CSS1 and C57BL/6J, only genetically different for chromosome 1, a correlation was found between motor activity levels, synchronous hind limb movement and neuro-anatomical differences in spinal motor neurons. Inclusion of the other inbred strains, however, did not show this direct correlation. These data verifies the complex nature of the mammalian motor system that may be further dissected using genetic mapping populations derived from these inbred strains.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>19778584</pmid><doi>10.1016/j.neuroscience.2009.09.008</doi><tpages>7</tpages></addata></record> |
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subjects | Animals Axons - ultrastructure Biological and medical sciences chromosome substitution strain Fundamental and applied biological sciences. Psychology home cage Male Mice Mice, Inbred Strains Motor Activity - genetics Motor Activity - physiology motor activity levels motor neuron anatomy Motor Neurons - ultrastructure mouse Neurology Species Specificity Spinal Nerve Roots - ultrastructure ventral roots Vertebrates: nervous system and sense organs |
title | Variations in ventral root axon morphology and locomotor behavior components across different inbred strains of mice |
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