Variations in ventral root axon morphology and locomotor behavior components across different inbred strains of mice

Abstract Locomotion is a complex behavior affected by many different brain- and spinal cord systems, as well as by variations in the peripheral nervous system. Recently, we found increased gene expression for EphA4 , a gene intricately involved in motor neuron development, between high-active parent...

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Veröffentlicht in:Neuroscience 2009-12, Vol.164 (4), p.1477-1483
Hauptverfasser: de Mooij-van Malsen, J.G, Yu, K.L, Veldman, H, Oppelaar, H, van den Berg, L.H, Olivier, B, Kas, M.J.H
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container_end_page 1483
container_issue 4
container_start_page 1477
container_title Neuroscience
container_volume 164
creator de Mooij-van Malsen, J.G
Yu, K.L
Veldman, H
Oppelaar, H
van den Berg, L.H
Olivier, B
Kas, M.J.H
description Abstract Locomotion is a complex behavior affected by many different brain- and spinal cord systems, as well as by variations in the peripheral nervous system. Recently, we found increased gene expression for EphA4 , a gene intricately involved in motor neuron development, between high-active parental strain C57BL/6J and the low-active chromosome substitution strain 1 (CSS1). CSS1 mice carry chromosome 1 from A/J mice in a C57BL/6J genetic background, allowing localization of quantitative trait loci (QTL) on chromosome 1. To find out whether differences in motor neuron anatomy, possibly related to the changes in EphA4 expression, are involved in the motor activity differences observed in these strains, motor performance in various behavioral paradigms and anatomical differences in the ventral roots were investigated. To correlate the behavioral profiles to the spinal motor neuron morphology, not only CSS1 and its parental strains C57BL/6J (host) and A/J (donor) were examined, but also a set of other mouse inbred strains (AKR/J, 129×1/SvJ and DBA/2J). Significant differences were found between inbred strains on home cage motor activity levels, the beam balance test, grip test performance, and on alternating versus synchronous hind limb movement (hind limb hopping). Also, considerable differences were found in spinal motor neuron morphology, with A/J and CSS1 showing smaller, possibly less developed, motor neuron axons compared to all other inbred strains. For CSS1 and C57BL/6J, only genetically different for chromosome 1, a correlation was found between motor activity levels, synchronous hind limb movement and neuro-anatomical differences in spinal motor neurons. Inclusion of the other inbred strains, however, did not show this direct correlation. These data verifies the complex nature of the mammalian motor system that may be further dissected using genetic mapping populations derived from these inbred strains.
doi_str_mv 10.1016/j.neuroscience.2009.09.008
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Recently, we found increased gene expression for EphA4 , a gene intricately involved in motor neuron development, between high-active parental strain C57BL/6J and the low-active chromosome substitution strain 1 (CSS1). CSS1 mice carry chromosome 1 from A/J mice in a C57BL/6J genetic background, allowing localization of quantitative trait loci (QTL) on chromosome 1. To find out whether differences in motor neuron anatomy, possibly related to the changes in EphA4 expression, are involved in the motor activity differences observed in these strains, motor performance in various behavioral paradigms and anatomical differences in the ventral roots were investigated. To correlate the behavioral profiles to the spinal motor neuron morphology, not only CSS1 and its parental strains C57BL/6J (host) and A/J (donor) were examined, but also a set of other mouse inbred strains (AKR/J, 129×1/SvJ and DBA/2J). 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Psychology ; home cage ; Male ; Mice ; Mice, Inbred Strains ; Motor Activity - genetics ; Motor Activity - physiology ; motor activity levels ; motor neuron anatomy ; Motor Neurons - ultrastructure ; mouse ; Neurology ; Species Specificity ; Spinal Nerve Roots - ultrastructure ; ventral roots ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience, 2009-12, Vol.164 (4), p.1477-1483</ispartof><rights>IBRO</rights><rights>2009 IBRO</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-1efca81b64141b09027d39ee8e182aba4625b5c47c8be3f7decc044d13fb5343</citedby><cites>FETCH-LOGICAL-c526t-1efca81b64141b09027d39ee8e182aba4625b5c47c8be3f7decc044d13fb5343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuroscience.2009.09.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=22195498$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19778584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Mooij-van Malsen, J.G</creatorcontrib><creatorcontrib>Yu, K.L</creatorcontrib><creatorcontrib>Veldman, H</creatorcontrib><creatorcontrib>Oppelaar, H</creatorcontrib><creatorcontrib>van den Berg, L.H</creatorcontrib><creatorcontrib>Olivier, B</creatorcontrib><creatorcontrib>Kas, M.J.H</creatorcontrib><title>Variations in ventral root axon morphology and locomotor behavior components across different inbred strains of mice</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Abstract Locomotion is a complex behavior affected by many different brain- and spinal cord systems, as well as by variations in the peripheral nervous system. Recently, we found increased gene expression for EphA4 , a gene intricately involved in motor neuron development, between high-active parental strain C57BL/6J and the low-active chromosome substitution strain 1 (CSS1). CSS1 mice carry chromosome 1 from A/J mice in a C57BL/6J genetic background, allowing localization of quantitative trait loci (QTL) on chromosome 1. To find out whether differences in motor neuron anatomy, possibly related to the changes in EphA4 expression, are involved in the motor activity differences observed in these strains, motor performance in various behavioral paradigms and anatomical differences in the ventral roots were investigated. To correlate the behavioral profiles to the spinal motor neuron morphology, not only CSS1 and its parental strains C57BL/6J (host) and A/J (donor) were examined, but also a set of other mouse inbred strains (AKR/J, 129×1/SvJ and DBA/2J). Significant differences were found between inbred strains on home cage motor activity levels, the beam balance test, grip test performance, and on alternating versus synchronous hind limb movement (hind limb hopping). Also, considerable differences were found in spinal motor neuron morphology, with A/J and CSS1 showing smaller, possibly less developed, motor neuron axons compared to all other inbred strains. For CSS1 and C57BL/6J, only genetically different for chromosome 1, a correlation was found between motor activity levels, synchronous hind limb movement and neuro-anatomical differences in spinal motor neurons. Inclusion of the other inbred strains, however, did not show this direct correlation. 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Psychology</topic><topic>home cage</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Motor Activity - genetics</topic><topic>Motor Activity - physiology</topic><topic>motor activity levels</topic><topic>motor neuron anatomy</topic><topic>Motor Neurons - ultrastructure</topic><topic>mouse</topic><topic>Neurology</topic><topic>Species Specificity</topic><topic>Spinal Nerve Roots - ultrastructure</topic><topic>ventral roots</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Mooij-van Malsen, J.G</creatorcontrib><creatorcontrib>Yu, K.L</creatorcontrib><creatorcontrib>Veldman, H</creatorcontrib><creatorcontrib>Oppelaar, H</creatorcontrib><creatorcontrib>van den Berg, L.H</creatorcontrib><creatorcontrib>Olivier, B</creatorcontrib><creatorcontrib>Kas, M.J.H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Mooij-van Malsen, J.G</au><au>Yu, K.L</au><au>Veldman, H</au><au>Oppelaar, H</au><au>van den Berg, L.H</au><au>Olivier, B</au><au>Kas, M.J.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variations in ventral root axon morphology and locomotor behavior components across different inbred strains of mice</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2009-12-29</date><risdate>2009</risdate><volume>164</volume><issue>4</issue><spage>1477</spage><epage>1483</epage><pages>1477-1483</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Abstract Locomotion is a complex behavior affected by many different brain- and spinal cord systems, as well as by variations in the peripheral nervous system. Recently, we found increased gene expression for EphA4 , a gene intricately involved in motor neuron development, between high-active parental strain C57BL/6J and the low-active chromosome substitution strain 1 (CSS1). CSS1 mice carry chromosome 1 from A/J mice in a C57BL/6J genetic background, allowing localization of quantitative trait loci (QTL) on chromosome 1. To find out whether differences in motor neuron anatomy, possibly related to the changes in EphA4 expression, are involved in the motor activity differences observed in these strains, motor performance in various behavioral paradigms and anatomical differences in the ventral roots were investigated. To correlate the behavioral profiles to the spinal motor neuron morphology, not only CSS1 and its parental strains C57BL/6J (host) and A/J (donor) were examined, but also a set of other mouse inbred strains (AKR/J, 129×1/SvJ and DBA/2J). Significant differences were found between inbred strains on home cage motor activity levels, the beam balance test, grip test performance, and on alternating versus synchronous hind limb movement (hind limb hopping). Also, considerable differences were found in spinal motor neuron morphology, with A/J and CSS1 showing smaller, possibly less developed, motor neuron axons compared to all other inbred strains. For CSS1 and C57BL/6J, only genetically different for chromosome 1, a correlation was found between motor activity levels, synchronous hind limb movement and neuro-anatomical differences in spinal motor neurons. Inclusion of the other inbred strains, however, did not show this direct correlation. These data verifies the complex nature of the mammalian motor system that may be further dissected using genetic mapping populations derived from these inbred strains.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>19778584</pmid><doi>10.1016/j.neuroscience.2009.09.008</doi><tpages>7</tpages></addata></record>
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source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Animals
Axons - ultrastructure
Biological and medical sciences
chromosome substitution strain
Fundamental and applied biological sciences. Psychology
home cage
Male
Mice
Mice, Inbred Strains
Motor Activity - genetics
Motor Activity - physiology
motor activity levels
motor neuron anatomy
Motor Neurons - ultrastructure
mouse
Neurology
Species Specificity
Spinal Nerve Roots - ultrastructure
ventral roots
Vertebrates: nervous system and sense organs
title Variations in ventral root axon morphology and locomotor behavior components across different inbred strains of mice
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