Synergistic anticandidal activity of xanthorrhizol in combination with ketoconazole or amphotericin B
Candida species are responsible for the fourth most common nosocominal bloodstream infection. Xanthorrhizol, a sesquiterpene compound isolated from Curcuma xanthorrhiza Roxb. has been reported to have anticandidal activity. The aim of this study is to investigate the synergistic anticandidal effect...
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| creator | Rukayadi, Yaya Lee, Kwanhyoung Lee, Myoung-su Yong, Dongeun Hwang, Jae-Kwan |
| description | Candida species are responsible for the fourth most common nosocominal bloodstream infection. Xanthorrhizol, a sesquiterpene compound isolated from Curcuma xanthorrhiza Roxb. has been reported to have anticandidal activity. The aim of this study is to investigate the synergistic anticandidal effect of xanthorrhizol in combination with ketoconazole or amphotericin B against Candida albicans, Candida glabrata, Candida guilliermondii, Candida krusei, Candida parapsilosis, and Candida tropicalis. Mostly, xanthorrhizol in combination with ketoconazole or amphotericin B exhibited the synergistic anticandidal effects against all species of Candida tested. In combination with xanthorrhizol, the concentration of ketoconazole or amphotericin B for inhibiting the growth of the tested Candida species could be reduced by greater-than-or-equal50%. Time-kill curves showed that 1/2 minimum inhibitory concentration (MIC) dose of xanthorrhizol, amphotericin B, or ketoconazole alone against each of the six Candida species did not inhibit the growth of all Candida species tested. However, 1/2 MIC dose of xanthorrhizol in combination with 1/2 MIC dose of ketoconazole or 1/2 MIC dose of amphotericin B exhibited growth inhibition of all Candida species tested and reduced viable cells by several logs within 4 h. These results support the potential use of xanthorrhizol as an anticandidal agent, and it can be used complementarily with other conventional antifungal agents. |
| doi_str_mv | 10.1111/j.1567-1364.2009.00548.x |
| format | Article |
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Xanthorrhizol, a sesquiterpene compound isolated from Curcuma xanthorrhiza Roxb. has been reported to have anticandidal activity. The aim of this study is to investigate the synergistic anticandidal effect of xanthorrhizol in combination with ketoconazole or amphotericin B against Candida albicans, Candida glabrata, Candida guilliermondii, Candida krusei, Candida parapsilosis, and Candida tropicalis. Mostly, xanthorrhizol in combination with ketoconazole or amphotericin B exhibited the synergistic anticandidal effects against all species of Candida tested. In combination with xanthorrhizol, the concentration of ketoconazole or amphotericin B for inhibiting the growth of the tested Candida species could be reduced by greater-than-or-equal50%. Time-kill curves showed that 1/2 minimum inhibitory concentration (MIC) dose of xanthorrhizol, amphotericin B, or ketoconazole alone against each of the six Candida species did not inhibit the growth of all Candida species tested. However, 1/2 MIC dose of xanthorrhizol in combination with 1/2 MIC dose of ketoconazole or 1/2 MIC dose of amphotericin B exhibited growth inhibition of all Candida species tested and reduced viable cells by several logs within 4 h. These results support the potential use of xanthorrhizol as an anticandidal agent, and it can be used complementarily with other conventional antifungal agents.</description><identifier>ISSN: 1567-1356</identifier><identifier>EISSN: 1567-1364</identifier><identifier>DOI: 10.1111/j.1567-1364.2009.00548.x</identifier><identifier>PMID: 19663917</identifier><language>eng</language><publisher>Oxford, UK: Oxford, UK : Blackwell Publishing Ltd</publisher><subject>Amphotericin B ; Amphotericin B - pharmacology ; anticandidal ; Antifungal agents ; Antifungal Agents - pharmacology ; Candida ; Candida - drug effects ; Colony Count, Microbial ; Curcuma - chemistry ; Drug Synergism ; Health risk assessment ; Ketoconazole ; Ketoconazole - pharmacokinetics ; Microbial Sensitivity Tests ; Microbial Viability - drug effects ; Minimum inhibitory concentration ; Molecular Structure ; Phenols - isolation & purification ; Phenols - pharmacology ; Species ; synergistic ; Time Factors ; Xanthorrhizol</subject><ispartof>FEMS yeast research, 2009-12, Vol.9 (8), p.1302-1311</ispartof><rights>2009 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved 2009</rights><rights>2009 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5138-4b384ad855b8ebd7d688be7b544c52e94d0001ac5c6b11c3945344d627bbef463</citedby><cites>FETCH-LOGICAL-c5138-4b384ad855b8ebd7d688be7b544c52e94d0001ac5c6b11c3945344d627bbef463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1567-1364.2009.00548.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1567-1364.2009.00548.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19663917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rukayadi, Yaya</creatorcontrib><creatorcontrib>Lee, Kwanhyoung</creatorcontrib><creatorcontrib>Lee, Myoung-su</creatorcontrib><creatorcontrib>Yong, Dongeun</creatorcontrib><creatorcontrib>Hwang, Jae-Kwan</creatorcontrib><title>Synergistic anticandidal activity of xanthorrhizol in combination with ketoconazole or amphotericin B</title><title>FEMS yeast research</title><addtitle>FEMS Yeast Res</addtitle><description>Candida species are responsible for the fourth most common nosocominal bloodstream infection. Xanthorrhizol, a sesquiterpene compound isolated from Curcuma xanthorrhiza Roxb. has been reported to have anticandidal activity. The aim of this study is to investigate the synergistic anticandidal effect of xanthorrhizol in combination with ketoconazole or amphotericin B against Candida albicans, Candida glabrata, Candida guilliermondii, Candida krusei, Candida parapsilosis, and Candida tropicalis. Mostly, xanthorrhizol in combination with ketoconazole or amphotericin B exhibited the synergistic anticandidal effects against all species of Candida tested. In combination with xanthorrhizol, the concentration of ketoconazole or amphotericin B for inhibiting the growth of the tested Candida species could be reduced by greater-than-or-equal50%. Time-kill curves showed that 1/2 minimum inhibitory concentration (MIC) dose of xanthorrhizol, amphotericin B, or ketoconazole alone against each of the six Candida species did not inhibit the growth of all Candida species tested. However, 1/2 MIC dose of xanthorrhizol in combination with 1/2 MIC dose of ketoconazole or 1/2 MIC dose of amphotericin B exhibited growth inhibition of all Candida species tested and reduced viable cells by several logs within 4 h. These results support the potential use of xanthorrhizol as an anticandidal agent, and it can be used complementarily with other conventional antifungal agents.</description><subject>Amphotericin B</subject><subject>Amphotericin B - pharmacology</subject><subject>anticandidal</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - pharmacology</subject><subject>Candida</subject><subject>Candida - drug effects</subject><subject>Colony Count, Microbial</subject><subject>Curcuma - chemistry</subject><subject>Drug Synergism</subject><subject>Health risk assessment</subject><subject>Ketoconazole</subject><subject>Ketoconazole - pharmacokinetics</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbial Viability - drug effects</subject><subject>Minimum inhibitory concentration</subject><subject>Molecular Structure</subject><subject>Phenols - isolation & purification</subject><subject>Phenols - pharmacology</subject><subject>Species</subject><subject>synergistic</subject><subject>Time Factors</subject><subject>Xanthorrhizol</subject><issn>1567-1356</issn><issn>1567-1364</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU1v1DAQhi0EoqXwF8ASB04JdvwZiQtUFJAqIVF64GTZjtP1ktiLndBdfj0OWRUJgYQP9kjzvDOvZwCAGNW4nJfbGjMuKkw4rRuE2hohRmW9vwdO7xL372LGT8CjnLcIYYGQfAhOcMs5abE4Be7qEFy68XnyFupQbh063-kBajv57346wNjDfclsYkob_yMO0Ado42h80JOPAd76aQO_uinaGHTJOxgT1ONuEyeXvC30m8fgQa-H7J4c3zNwffH28_n76vLjuw_nry8ryzCRFTVEUt1Jxox0phMdl9I4YRilljWupR0qf9CWWW4wtqSljFDa8UYY43rKyRl4sdbdpfhtdnlSo8_WDYMOLs5ZCUIxaQleyOd_kNs4p1DMqYYQhpmgRBRKrpRNMefkerVLftTpoDBSyybUVi1DVsvA1bIJ9WsTal-kT48NZjO67rfwOPoCvFqBWz-4w38XVhdfPpWgyMkqj_PuH-Lqb66erapeR6Vvks_q-qpBmCDMi7Fi7Sdl17BK</recordid><startdate>200912</startdate><enddate>200912</enddate><creator>Rukayadi, Yaya</creator><creator>Lee, Kwanhyoung</creator><creator>Lee, Myoung-su</creator><creator>Yong, Dongeun</creator><creator>Hwang, Jae-Kwan</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><general>Oxford University Press</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200912</creationdate><title>Synergistic anticandidal activity of xanthorrhizol in combination with ketoconazole or amphotericin B</title><author>Rukayadi, Yaya ; Lee, Kwanhyoung ; Lee, Myoung-su ; Yong, Dongeun ; Hwang, Jae-Kwan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5138-4b384ad855b8ebd7d688be7b544c52e94d0001ac5c6b11c3945344d627bbef463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Amphotericin B</topic><topic>Amphotericin B - pharmacology</topic><topic>anticandidal</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - pharmacology</topic><topic>Candida</topic><topic>Candida - drug effects</topic><topic>Colony Count, Microbial</topic><topic>Curcuma - chemistry</topic><topic>Drug Synergism</topic><topic>Health risk assessment</topic><topic>Ketoconazole</topic><topic>Ketoconazole - pharmacokinetics</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbial Viability - drug effects</topic><topic>Minimum inhibitory concentration</topic><topic>Molecular Structure</topic><topic>Phenols - isolation & purification</topic><topic>Phenols - pharmacology</topic><topic>Species</topic><topic>synergistic</topic><topic>Time Factors</topic><topic>Xanthorrhizol</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rukayadi, Yaya</creatorcontrib><creatorcontrib>Lee, Kwanhyoung</creatorcontrib><creatorcontrib>Lee, Myoung-su</creatorcontrib><creatorcontrib>Yong, Dongeun</creatorcontrib><creatorcontrib>Hwang, Jae-Kwan</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>FEMS yeast research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rukayadi, Yaya</au><au>Lee, Kwanhyoung</au><au>Lee, Myoung-su</au><au>Yong, Dongeun</au><au>Hwang, Jae-Kwan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synergistic anticandidal activity of xanthorrhizol in combination with ketoconazole or amphotericin B</atitle><jtitle>FEMS yeast research</jtitle><addtitle>FEMS Yeast Res</addtitle><date>2009-12</date><risdate>2009</risdate><volume>9</volume><issue>8</issue><spage>1302</spage><epage>1311</epage><pages>1302-1311</pages><issn>1567-1356</issn><eissn>1567-1364</eissn><abstract>Candida species are responsible for the fourth most common nosocominal bloodstream infection. Xanthorrhizol, a sesquiterpene compound isolated from Curcuma xanthorrhiza Roxb. has been reported to have anticandidal activity. The aim of this study is to investigate the synergistic anticandidal effect of xanthorrhizol in combination with ketoconazole or amphotericin B against Candida albicans, Candida glabrata, Candida guilliermondii, Candida krusei, Candida parapsilosis, and Candida tropicalis. Mostly, xanthorrhizol in combination with ketoconazole or amphotericin B exhibited the synergistic anticandidal effects against all species of Candida tested. In combination with xanthorrhizol, the concentration of ketoconazole or amphotericin B for inhibiting the growth of the tested Candida species could be reduced by greater-than-or-equal50%. Time-kill curves showed that 1/2 minimum inhibitory concentration (MIC) dose of xanthorrhizol, amphotericin B, or ketoconazole alone against each of the six Candida species did not inhibit the growth of all Candida species tested. However, 1/2 MIC dose of xanthorrhizol in combination with 1/2 MIC dose of ketoconazole or 1/2 MIC dose of amphotericin B exhibited growth inhibition of all Candida species tested and reduced viable cells by several logs within 4 h. These results support the potential use of xanthorrhizol as an anticandidal agent, and it can be used complementarily with other conventional antifungal agents.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>19663917</pmid><doi>10.1111/j.1567-1364.2009.00548.x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amphotericin B Amphotericin B - pharmacology anticandidal Antifungal agents Antifungal Agents - pharmacology Candida Candida - drug effects Colony Count, Microbial Curcuma - chemistry Drug Synergism Health risk assessment Ketoconazole Ketoconazole - pharmacokinetics Microbial Sensitivity Tests Microbial Viability - drug effects Minimum inhibitory concentration Molecular Structure Phenols - isolation & purification Phenols - pharmacology Species synergistic Time Factors Xanthorrhizol |
| title | Synergistic anticandidal activity of xanthorrhizol in combination with ketoconazole or amphotericin B |
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