Inhibition of Rho-Associated Kinase Signaling Prevents Breast Cancer Metastasis to Human Bone

Rho-associated kinase (ROCK) signaling plays a fundamental role in regulating cell morphology, adhesion, and motility. Aberrant expression of ROCK is related to tumor metastases and poor clinical outcome. Here, we show that ROCK expression is increased in metastatic human mammary tumors and breast c...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2009-11, Vol.69 (22), p.8742-8751
Hauptverfasser:	SIJIN LIU, GOLDSTEIN, Robert H, SCEPANSKY, Ellen M, ROSENBLATT, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Blotting, Western Bone Neoplasms - enzymology Bone Neoplasms - genetics Bone Neoplasms - secondary Breast Neoplasms - enzymology Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Movement - drug effects Cell Movement - physiology Enzyme Inhibitors - pharmacology Female Flow Cytometry Gene Expression - drug effects Gene Expression Profiling Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Mice MicroRNAs - drug effects MicroRNAs - genetics MicroRNAs - metabolism Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Neoplasm Metastasis - genetics Neoplasm Metastasis - pathology Oligonucleotide Array Sequence Analysis Pharmacology. Drug treatments Proto-Oncogene Proteins c-myc - drug effects Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Reverse Transcriptase Polymerase Chain Reaction rho-Associated Kinases - metabolism RNA, Messenger RNA, Small Interfering Signal Transduction - physiology Tumors
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