Colorimetric, High-Throughput Assay for Screening Angiotensin I-Converting Enzyme Inhibitors

Angiotensin I-converting enzyme (ACE) plays a pivotal role in blood pressure regulation. A colorimetric assay to measure hippuric acid (HA) was transformed into a rapid ACE assay wherein the released HA from the substrate hippuryl-histidyl-leucine (HHL) is mixed with pyridine and benzene sulfonyl ch...

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Veröffentlicht in:	Analytical chemistry (Washington) 2009-11, Vol.81 (22), p.9388-9394
Hauptverfasser:	Jimsheena, V. K, Gowda, Lalitha R
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE inhibitors Analytical chemistry Angiotensin-Converting Enzyme Inhibitors - analysis Angiotensin-Converting Enzyme Inhibitors - pharmacology Blood pressure Chemistry Chromatographic methods and physical methods associated with chromatography Colorimetry - methods Exact sciences and technology Hippurates - metabolism Hogs Ion chromatography Lungs Oligopeptides - metabolism Other chromatographic methods Spectrometric and optical methods
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