A Modular Synthesis of Alkynyl-Phosphocholine Headgroups for Labeling Sphingomyelin and Phosphatidylcholine

A general route to phospho- and sphingolipids that incorporate an alkyne in the phosphocholine headgroup is described. The strategy preserves the ammonium functionality of the phosphocholine and can be easily modified to introduce desired functional groups at the N-acyl chain. The targets accessible...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of organic chemistry 2009-11, Vol.74 (22), p.8669-8674
Hauptverfasser:	Sandbhor, Mahendra S, Key, Jessie A, Strelkov, Ileana S, Cairo, Christopher W
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Lipids Molecular Structure Organic chemistry Phosphatidylcholines - chemical synthesis Phosphatidylcholines - chemistry Phosphorylcholine - chemistry Preparations and properties Sphingomyelins - chemical synthesis Sphingomyelins - chemistry Staining and Labeling
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!