Novel Pentacyclic seco-Prezizaane-Type Sesquiterpenoids with Neurotrophic Properties from Illicium jiadifengpi

Three novel seco-prezizaane-type sesquiterpenoids, jiadifenolide (1), jiadifenoxolane A (2), and jiadifenoxolane B (3), were isolated from the pericarps of Illicium jiadifengpi. Their pentacyclic cage structures were determined by 2D-NMR methods, chemical conversion, and single-crystal X-ray analysi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Organic letters 2009-11, Vol.11 (22), p.5190-5193
Hauptverfasser:	Kubo, Miwa, Okada, Chihiro, Huang, Jian-Mei, Harada, Kenichi, Hioki, Hideaki, Fukuyama, Yoshiyasu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Cerebral Cortex - cytology Crystallography, X-Ray Dose-Response Relationship, Drug Illicium - chemistry Models, Molecular Molecular Conformation Neurons - cytology Neurons - drug effects Rats Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Species Specificity Stereoisomerism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Three novel seco-prezizaane-type sesquiterpenoids, jiadifenolide (1), jiadifenoxolane A (2), and jiadifenoxolane B (3), were isolated from the pericarps of Illicium jiadifengpi. Their pentacyclic cage structures were determined by 2D-NMR methods, chemical conversion, and single-crystal X-ray analysis. Compounds 1 and 2 strongly promote neurite outgrowth in primary cultured rat cortical neurons at concentrations ranging from 0.01 to 10 μM.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol9021029