Inhibition of Urease Activity by Dipeptidyl Hydroxamic Acids
A series of dipeptidyl hydroxamic acids (H-X-Gly-NHOH : X=amino acid residues) was synthesized, and the inhibitory activity against Jack bean and Proteus mirabilis ureases [EC 3.5.1.5] was examined. A number of H-X-Gly-NHOH inhibited Jack bean urease with an I50 of the order of 10-6M and inhibited P...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1992/10/25, Vol.40(10), pp.2764-2768 |
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| container_issue | 10 |
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| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 40 |
| creator | ODAKE, Shinjiro NAKAHASHI, Kazuaki MORIKAWA, Tadanori TAKEBE, Sachiko KOBASHI, Kyoichi |
| description | A series of dipeptidyl hydroxamic acids (H-X-Gly-NHOH : X=amino acid residues) was synthesized, and the inhibitory activity against Jack bean and Proteus mirabilis ureases [EC 3.5.1.5] was examined. A number of H-X-Gly-NHOH inhibited Jack bean urease with an I50 of the order of 10-6M and inhibited Proteus mirabilis urease with an I50 of the order of 10-5M. The inhibition against Jack bean urease was more potent than that with the corresponding aminoacyl hydroxamic acids (H-X-NHOH). |
| doi_str_mv | 10.1248/cpb.40.2764 |
| format | Article |
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A number of H-X-Gly-NHOH inhibited Jack bean urease with an I50 of the order of 10-6M and inhibited Proteus mirabilis urease with an I50 of the order of 10-5M. 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Pharm. Bull.</addtitle><description>A series of dipeptidyl hydroxamic acids (H-X-Gly-NHOH : X=amino acid residues) was synthesized, and the inhibitory activity against Jack bean and Proteus mirabilis ureases [EC 3.5.1.5] was examined. A number of H-X-Gly-NHOH inhibited Jack bean urease with an I50 of the order of 10-6M and inhibited Proteus mirabilis urease with an I50 of the order of 10-5M. The inhibition against Jack bean urease was more potent than that with the corresponding aminoacyl hydroxamic acids (H-X-NHOH).</description><subject>Chemistry</subject><subject>dipeptide</subject><subject>Dipeptides - chemistry</subject><subject>Dipeptides - pharmacology</subject><subject>Exact sciences and technology</subject><subject>Fabaceae - enzymology</subject><subject>Humans</subject><subject>hydroxamic acid</subject><subject>Hydroxamic Acids - chemistry</subject><subject>Hydroxamic Acids - pharmacology</subject><subject>inhibitor</subject><subject>Organic chemistry</subject><subject>Peptides</subject><subject>Plants, Medicinal</subject><subject>Preparations and properties</subject><subject>Proteus mirabilis - enzymology</subject><subject>urease</subject><subject>Urease - antagonists & inhibitors</subject><subject>Urease - urine</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM1LxDAQxYMouq6ePAsFxYt0zXcb8CLrxy4seHHPIUlTzdJta9IV-9-b0kXBywzM-zFv5gFwgeAMYZrfmVbPKJzhjNMDMEGEZinDmByCCYRQpJhwcgJOQ9hAiBnMyDE4RpRTBPkE3C_rD6dd55o6acpk7a0KNnkwnftyXZ_oPnl0rW07V_RVsugL33yrrTORcEU4A0elqoI93_cpWD8_vc0X6er1ZTl_WKWGk6xLccFLkReZpoUWVjOksBAkJ4wom2OVMcFoHEEjiCLKMCi4Nii-g3VBLTVkCm7Gva1vPnc2dHLrgrFVpWrb7ILMCEWE5yyCV__ATbPzdbxNxo8h5pRzHKnbkTK-CcHbUrbebZXvJYJySFTGRCWFckg00pf7nTu9tcUfO0YY9eu9roJRVelVbVz4xShHCAsSsecR24ROvdtfXfnOmcoOlkiwfLCNV4x18P8DPpSXtiY_fauUJQ</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>ODAKE, Shinjiro</creator><creator>NAKAHASHI, Kazuaki</creator><creator>MORIKAWA, Tadanori</creator><creator>TAKEBE, Sachiko</creator><creator>KOBASHI, Kyoichi</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Inhibition of Urease Activity by Dipeptidyl Hydroxamic Acids</title><author>ODAKE, Shinjiro ; NAKAHASHI, Kazuaki ; MORIKAWA, Tadanori ; TAKEBE, Sachiko ; KOBASHI, Kyoichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c637t-2d6f98d7b4db9eb51a29938353ae82a75954a290c93a3ac5096bc12762bd4e4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Chemistry</topic><topic>dipeptide</topic><topic>Dipeptides - chemistry</topic><topic>Dipeptides - pharmacology</topic><topic>Exact sciences and technology</topic><topic>Fabaceae - enzymology</topic><topic>Humans</topic><topic>hydroxamic acid</topic><topic>Hydroxamic Acids - chemistry</topic><topic>Hydroxamic Acids - pharmacology</topic><topic>inhibitor</topic><topic>Organic chemistry</topic><topic>Peptides</topic><topic>Plants, Medicinal</topic><topic>Preparations and properties</topic><topic>Proteus mirabilis - enzymology</topic><topic>urease</topic><topic>Urease - antagonists & inhibitors</topic><topic>Urease - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ODAKE, Shinjiro</creatorcontrib><creatorcontrib>NAKAHASHI, Kazuaki</creatorcontrib><creatorcontrib>MORIKAWA, Tadanori</creatorcontrib><creatorcontrib>TAKEBE, Sachiko</creatorcontrib><creatorcontrib>KOBASHI, Kyoichi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ODAKE, Shinjiro</au><au>NAKAHASHI, Kazuaki</au><au>MORIKAWA, Tadanori</au><au>TAKEBE, Sachiko</au><au>KOBASHI, Kyoichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of Urease Activity by Dipeptidyl Hydroxamic Acids</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1992</date><risdate>1992</risdate><volume>40</volume><issue>10</issue><spage>2764</spage><epage>2768</epage><pages>2764-2768</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>A series of dipeptidyl hydroxamic acids (H-X-Gly-NHOH : X=amino acid residues) was synthesized, and the inhibitory activity against Jack bean and Proteus mirabilis ureases [EC 3.5.1.5] was examined. A number of H-X-Gly-NHOH inhibited Jack bean urease with an I50 of the order of 10-6M and inhibited Proteus mirabilis urease with an I50 of the order of 10-5M. The inhibition against Jack bean urease was more potent than that with the corresponding aminoacyl hydroxamic acids (H-X-NHOH).</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>1464106</pmid><doi>10.1248/cpb.40.2764</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chemical and Pharmaceutical Bulletin, 1992/10/25, Vol.40(10), pp.2764-2768 |
| issn | 0009-2363 1347-5223 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Chemistry dipeptide Dipeptides - chemistry Dipeptides - pharmacology Exact sciences and technology Fabaceae - enzymology Humans hydroxamic acid Hydroxamic Acids - chemistry Hydroxamic Acids - pharmacology inhibitor Organic chemistry Peptides Plants, Medicinal Preparations and properties Proteus mirabilis - enzymology urease Urease - antagonists & inhibitors Urease - urine |
| title | Inhibition of Urease Activity by Dipeptidyl Hydroxamic Acids |
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