Astrocyte Differentiation of Neural Precursor Cells is Enhanced by Retinoic Acid Through a Change in Epigenetic Modification

Neurons, astrocytes, and oligodendrocytes—the three major cell types that comprise the central nervous system—are generated from common multipotent neural precursor cells (NPCs). Members of the interleukin‐6 family of cytokines, including leukemia inhibitory factor (LIF), induce astrocyte differenti...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2009-11, Vol.27 (11), p.2744-2752
Hauptverfasser:	Asano, Hirotsugu, Aonuma, Makoto, Sanosaka, Tsukasa, Kohyama, Jun, Namihira, Masakazu, Nakashima, Kinichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation - drug effects Animals Astrocyte Astrocytes - cytology Astrocytes - drug effects Astrocytes - metabolism Cell Differentiation - drug effects Cells, Cultured Chromatin Immunoprecipitation Drug Synergism Epigenesis, Genetic - drug effects Epigenesis, Genetic - genetics Epithelial Cells Female Glial Fibrillary Acidic Protein - genetics Histone acetylation Histones - metabolism Keratolytic Agents - pharmacology Leukemia Inhibitory Factor - pharmacology Mice Neural precursor cells Neurons - cytology Pregnancy Promoter Regions, Genetic - genetics Promoter Regions, Genetic - physiology Response Elements - genetics Response Elements - physiology Retinoic acid Reverse Transcriptase Polymerase Chain Reaction STAT3 STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism STAT3 Transcription Factor - physiology Stem Cells - cytology Stem Cells - drug effects Stem Cells - metabolism Tretinoin - pharmacology
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