The TLR1/2 agonist PAM(3)CSK(4) instructs commitment of human hematopoietic stem cells to a myeloid cell fate

Toll-like receptors (TLRs) constitute a family of nonpolymorphic receptors that are devoted to pathogen recognition. In this work, we have explored the impact of TLR ligands (TLR-L) on human hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs). We show that HSCs and HPCs have a...

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Veröffentlicht in:	Leukemia 2009-11, Vol.23 (11), p.2063-2074
Hauptverfasser:	De Luca, K, Frances-Duvert, V, Asensio, M-J, Ihsani, R, Debien, E, Taillardet, M, Verhoeyen, E, Bella, C, Lantheaume, S, Genestier, L, Defrance, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD34 - metabolism B-Lymphocytes - cytology B-Lymphocytes - drug effects Cell Differentiation - drug effects Cell Line Cell Lineage - drug effects DNA-Binding Proteins - genetics Fetal Blood - cytology Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Humans Lipopeptides - pharmacology Lymphopoiesis - drug effects Mice Mice, Inbred C57BL Mice, Knockout Myeloid Cells - cytology Stromal Cells - cytology Toll-Like Receptor 1 - agonists Toll-Like Receptor 1 - genetics Toll-Like Receptor 2 - agonists Toll-Like Receptor 2 - genetics Transcription, Genetic - drug effects
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