Prediagnostic Total and High-Density Lipoprotein Cholesterol and Risk of Cancer
Background: Circulating total cholesterol has been inversely associated with cancer risk; however, the role of reverse causation and the associations for high-density lipoprotein (HDL) cholesterol have not been fully characterized. We examined the relationship between serum total and HDL cholesterol...
Gespeichert in:
| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2009-11, Vol.18 (11), p.2814-2821 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2821 |
|---|---|
| container_issue | 11 |
| container_start_page | 2814 |
| container_title | Cancer epidemiology, biomarkers & prevention |
| container_volume | 18 |
| creator | AHN, Jiyoung LIM, Unhee WEINSTEIN, Stephanie J SCHATZKIN, Arthur HAYES, Richard B VIRTAMO, Jarmo ALBANES, Demetrius |
| description | Background: Circulating total cholesterol has been inversely associated with cancer risk; however, the role of reverse causation
and the associations for high-density lipoprotein (HDL) cholesterol have not been fully characterized. We examined the relationship
between serum total and HDL cholesterol and risk of overall and site-specific cancers among 29,093 men in the Alpha-Tocopherol,
Beta-Carotene Cancer Prevention (ATBC) Study cohort.
Methods: Fasting serum total and HDL cholesterol were assayed at baseline, and 7,545 incident cancers were identified during
up to 18 years of follow-up. Multivariable proportional hazards models were conducted to estimate relative risks (RR).
Results: Higher serum total cholesterol concentration was associated with decreased risk of cancer overall (RR for comparing
high versus low quintile, 0.85; 95% confidence interval, 0.79-0.91; P trend 276.7 versus 55.3 versus |
| doi_str_mv | 10.1158/1055-9965.EPI-08-1248 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734132719</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>734132719</sourcerecordid><originalsourceid>FETCH-LOGICAL-c537t-378a28d061c8c7bad04e6f46a3d47d4eb8ece9b1013382ead14eeec3580d24a63</originalsourceid><addsrcrecordid>eNpFkE1LAzEQhoMofv8EZS8iHlYzm2STPUr9hIIieg5pMmuj201Ntoj_3tRWPc0wPDPz8hByBPQcQKgLoEKUTVOL8-vH-5KqEiquNsguCKZKKYXYzP0vs0P2UnqjlMpGiG2yA41SUijYJQ-PEZ03r31Ig7fFcxhMV5jeFXf-dVpeYZ_88FWM_TzMYxjQ98VoGjpMA8awAp98ei9CW4xMbzEekK3WdAkP13WfvNxcP4_uyvHD7f3oclxaweRQMqlMpRytwSorJ8ZRjnXLa8Mcl47jRKHFZgIUGFMVGgccES0TirqKm5rtk9PV3RzrY5Hz6JlPFrvO9BgWSUvGgVUSmkyKFWljSCliq-fRz0z80kD1UqVeatJLTTqr1DQPssq8d7z-sJjM0P1vrd1l4GQNmGRN18YswKc_rqpA1pwvA5ytuGlW-ukjavujKmJCE-1UQ_4IulLA2TexDIrN</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>734132719</pqid></control><display><type>article</type><title>Prediagnostic Total and High-Density Lipoprotein Cholesterol and Risk of Cancer</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>AHN, Jiyoung ; LIM, Unhee ; WEINSTEIN, Stephanie J ; SCHATZKIN, Arthur ; HAYES, Richard B ; VIRTAMO, Jarmo ; ALBANES, Demetrius</creator><creatorcontrib>AHN, Jiyoung ; LIM, Unhee ; WEINSTEIN, Stephanie J ; SCHATZKIN, Arthur ; HAYES, Richard B ; VIRTAMO, Jarmo ; ALBANES, Demetrius</creatorcontrib><description>Background: Circulating total cholesterol has been inversely associated with cancer risk; however, the role of reverse causation
and the associations for high-density lipoprotein (HDL) cholesterol have not been fully characterized. We examined the relationship
between serum total and HDL cholesterol and risk of overall and site-specific cancers among 29,093 men in the Alpha-Tocopherol,
Beta-Carotene Cancer Prevention (ATBC) Study cohort.
Methods: Fasting serum total and HDL cholesterol were assayed at baseline, and 7,545 incident cancers were identified during
up to 18 years of follow-up. Multivariable proportional hazards models were conducted to estimate relative risks (RR).
Results: Higher serum total cholesterol concentration was associated with decreased risk of cancer overall (RR for comparing
high versus low quintile, 0.85; 95% confidence interval, 0.79-0.91; P trend <0.001; >276.7 versus <203.9 mg/dL), and the inverse association was particularly evident for cancers of the lung and
liver. These associations were no longer significant, however, when cases diagnosed during the first 9 years of follow-up
were excluded. Greater HDL cholesterol was also associated with decreased risk of cancer (RR for high versus low quintile,
0.89; 95% confidence interval, 0.83-0.97; P trend = 0.01; >55.3 versus <36.2 mg/dL). The inverse association of HDL cholesterol was evident for cancers of lung, prostate,
liver, and the hematopoietic system, and the associations of HDL cholesterol with liver and lung cancers remained after excluding
cases diagnosed within 12 years of study entry.
Conclusion: Our findings suggest that prior observations regarding serum total cholesterol and cancer are largely explained
by reverse causation. Although chance and reverse causation may explain some of the inverse HDL associations, we cannot rule
out some etiologic role for this lipid fraction. (Cancer Epidemiol Biomarkers Prev 2009;18(11):2814–21)</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-08-1248</identifier><identifier>PMID: 19887581</identifier><identifier>CODEN: CEBPE4</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Biological and medical sciences ; cancer ; cholesterol ; Cholesterol - blood ; Cholesterol, HDL - blood ; cohort ; Cohort Studies ; Dietary Supplements ; Double-Blind Method ; Follow-Up Studies ; high density lipoprotein cholesterol ; Humans ; Male ; Medical sciences ; Middle Aged ; Neoplasms - blood ; Neoplasms - diagnosis ; Neoplasms - epidemiology ; Prognosis ; prospective ; Prospective Studies ; risk ; Risk Factors ; serum ; Tumors</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2009-11, Vol.18 (11), p.2814-2821</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-378a28d061c8c7bad04e6f46a3d47d4eb8ece9b1013382ead14eeec3580d24a63</citedby><cites>FETCH-LOGICAL-c537t-378a28d061c8c7bad04e6f46a3d47d4eb8ece9b1013382ead14eeec3580d24a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22176449$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19887581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AHN, Jiyoung</creatorcontrib><creatorcontrib>LIM, Unhee</creatorcontrib><creatorcontrib>WEINSTEIN, Stephanie J</creatorcontrib><creatorcontrib>SCHATZKIN, Arthur</creatorcontrib><creatorcontrib>HAYES, Richard B</creatorcontrib><creatorcontrib>VIRTAMO, Jarmo</creatorcontrib><creatorcontrib>ALBANES, Demetrius</creatorcontrib><title>Prediagnostic Total and High-Density Lipoprotein Cholesterol and Risk of Cancer</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Background: Circulating total cholesterol has been inversely associated with cancer risk; however, the role of reverse causation
and the associations for high-density lipoprotein (HDL) cholesterol have not been fully characterized. We examined the relationship
between serum total and HDL cholesterol and risk of overall and site-specific cancers among 29,093 men in the Alpha-Tocopherol,
Beta-Carotene Cancer Prevention (ATBC) Study cohort.
Methods: Fasting serum total and HDL cholesterol were assayed at baseline, and 7,545 incident cancers were identified during
up to 18 years of follow-up. Multivariable proportional hazards models were conducted to estimate relative risks (RR).
Results: Higher serum total cholesterol concentration was associated with decreased risk of cancer overall (RR for comparing
high versus low quintile, 0.85; 95% confidence interval, 0.79-0.91; P trend <0.001; >276.7 versus <203.9 mg/dL), and the inverse association was particularly evident for cancers of the lung and
liver. These associations were no longer significant, however, when cases diagnosed during the first 9 years of follow-up
were excluded. Greater HDL cholesterol was also associated with decreased risk of cancer (RR for high versus low quintile,
0.89; 95% confidence interval, 0.83-0.97; P trend = 0.01; >55.3 versus <36.2 mg/dL). The inverse association of HDL cholesterol was evident for cancers of lung, prostate,
liver, and the hematopoietic system, and the associations of HDL cholesterol with liver and lung cancers remained after excluding
cases diagnosed within 12 years of study entry.
Conclusion: Our findings suggest that prior observations regarding serum total cholesterol and cancer are largely explained
by reverse causation. Although chance and reverse causation may explain some of the inverse HDL associations, we cannot rule
out some etiologic role for this lipid fraction. (Cancer Epidemiol Biomarkers Prev 2009;18(11):2814–21)</description><subject>Biological and medical sciences</subject><subject>cancer</subject><subject>cholesterol</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>cohort</subject><subject>Cohort Studies</subject><subject>Dietary Supplements</subject><subject>Double-Blind Method</subject><subject>Follow-Up Studies</subject><subject>high density lipoprotein cholesterol</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasms - blood</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - epidemiology</subject><subject>Prognosis</subject><subject>prospective</subject><subject>Prospective Studies</subject><subject>risk</subject><subject>Risk Factors</subject><subject>serum</subject><subject>Tumors</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LAzEQhoMofv8EZS8iHlYzm2STPUr9hIIieg5pMmuj201Ntoj_3tRWPc0wPDPz8hByBPQcQKgLoEKUTVOL8-vH-5KqEiquNsguCKZKKYXYzP0vs0P2UnqjlMpGiG2yA41SUijYJQ-PEZ03r31Ig7fFcxhMV5jeFXf-dVpeYZ_88FWM_TzMYxjQ98VoGjpMA8awAp98ei9CW4xMbzEekK3WdAkP13WfvNxcP4_uyvHD7f3oclxaweRQMqlMpRytwSorJ8ZRjnXLa8Mcl47jRKHFZgIUGFMVGgccES0TirqKm5rtk9PV3RzrY5Hz6JlPFrvO9BgWSUvGgVUSmkyKFWljSCliq-fRz0z80kD1UqVeatJLTTqr1DQPssq8d7z-sJjM0P1vrd1l4GQNmGRN18YswKc_rqpA1pwvA5ytuGlW-ukjavujKmJCE-1UQ_4IulLA2TexDIrN</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>AHN, Jiyoung</creator><creator>LIM, Unhee</creator><creator>WEINSTEIN, Stephanie J</creator><creator>SCHATZKIN, Arthur</creator><creator>HAYES, Richard B</creator><creator>VIRTAMO, Jarmo</creator><creator>ALBANES, Demetrius</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Prediagnostic Total and High-Density Lipoprotein Cholesterol and Risk of Cancer</title><author>AHN, Jiyoung ; LIM, Unhee ; WEINSTEIN, Stephanie J ; SCHATZKIN, Arthur ; HAYES, Richard B ; VIRTAMO, Jarmo ; ALBANES, Demetrius</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-378a28d061c8c7bad04e6f46a3d47d4eb8ece9b1013382ead14eeec3580d24a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>cancer</topic><topic>cholesterol</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>cohort</topic><topic>Cohort Studies</topic><topic>Dietary Supplements</topic><topic>Double-Blind Method</topic><topic>Follow-Up Studies</topic><topic>high density lipoprotein cholesterol</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasms - blood</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - epidemiology</topic><topic>Prognosis</topic><topic>prospective</topic><topic>Prospective Studies</topic><topic>risk</topic><topic>Risk Factors</topic><topic>serum</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AHN, Jiyoung</creatorcontrib><creatorcontrib>LIM, Unhee</creatorcontrib><creatorcontrib>WEINSTEIN, Stephanie J</creatorcontrib><creatorcontrib>SCHATZKIN, Arthur</creatorcontrib><creatorcontrib>HAYES, Richard B</creatorcontrib><creatorcontrib>VIRTAMO, Jarmo</creatorcontrib><creatorcontrib>ALBANES, Demetrius</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AHN, Jiyoung</au><au>LIM, Unhee</au><au>WEINSTEIN, Stephanie J</au><au>SCHATZKIN, Arthur</au><au>HAYES, Richard B</au><au>VIRTAMO, Jarmo</au><au>ALBANES, Demetrius</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediagnostic Total and High-Density Lipoprotein Cholesterol and Risk of Cancer</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>18</volume><issue>11</issue><spage>2814</spage><epage>2821</epage><pages>2814-2821</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><coden>CEBPE4</coden><abstract>Background: Circulating total cholesterol has been inversely associated with cancer risk; however, the role of reverse causation
and the associations for high-density lipoprotein (HDL) cholesterol have not been fully characterized. We examined the relationship
between serum total and HDL cholesterol and risk of overall and site-specific cancers among 29,093 men in the Alpha-Tocopherol,
Beta-Carotene Cancer Prevention (ATBC) Study cohort.
Methods: Fasting serum total and HDL cholesterol were assayed at baseline, and 7,545 incident cancers were identified during
up to 18 years of follow-up. Multivariable proportional hazards models were conducted to estimate relative risks (RR).
Results: Higher serum total cholesterol concentration was associated with decreased risk of cancer overall (RR for comparing
high versus low quintile, 0.85; 95% confidence interval, 0.79-0.91; P trend <0.001; >276.7 versus <203.9 mg/dL), and the inverse association was particularly evident for cancers of the lung and
liver. These associations were no longer significant, however, when cases diagnosed during the first 9 years of follow-up
were excluded. Greater HDL cholesterol was also associated with decreased risk of cancer (RR for high versus low quintile,
0.89; 95% confidence interval, 0.83-0.97; P trend = 0.01; >55.3 versus <36.2 mg/dL). The inverse association of HDL cholesterol was evident for cancers of lung, prostate,
liver, and the hematopoietic system, and the associations of HDL cholesterol with liver and lung cancers remained after excluding
cases diagnosed within 12 years of study entry.
Conclusion: Our findings suggest that prior observations regarding serum total cholesterol and cancer are largely explained
by reverse causation. Although chance and reverse causation may explain some of the inverse HDL associations, we cannot rule
out some etiologic role for this lipid fraction. (Cancer Epidemiol Biomarkers Prev 2009;18(11):2814–21)</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>19887581</pmid><doi>10.1158/1055-9965.EPI-08-1248</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1055-9965 |
| ispartof | Cancer epidemiology, biomarkers & prevention, 2009-11, Vol.18 (11), p.2814-2821 |
| issn | 1055-9965 1538-7755 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734132719 |
| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biological and medical sciences cancer cholesterol Cholesterol - blood Cholesterol, HDL - blood cohort Cohort Studies Dietary Supplements Double-Blind Method Follow-Up Studies high density lipoprotein cholesterol Humans Male Medical sciences Middle Aged Neoplasms - blood Neoplasms - diagnosis Neoplasms - epidemiology Prognosis prospective Prospective Studies risk Risk Factors serum Tumors |
| title | Prediagnostic Total and High-Density Lipoprotein Cholesterol and Risk of Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T21%3A42%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prediagnostic%20Total%20and%20High-Density%20Lipoprotein%20Cholesterol%20and%20Risk%20of%20Cancer&rft.jtitle=Cancer%20epidemiology,%20biomarkers%20&%20prevention&rft.au=AHN,%20Jiyoung&rft.date=2009-11-01&rft.volume=18&rft.issue=11&rft.spage=2814&rft.epage=2821&rft.pages=2814-2821&rft.issn=1055-9965&rft.eissn=1538-7755&rft.coden=CEBPE4&rft_id=info:doi/10.1158/1055-9965.EPI-08-1248&rft_dat=%3Cproquest_cross%3E734132719%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=734132719&rft_id=info:pmid/19887581&rfr_iscdi=true |