Gyral and Sulcal Cortical Thinning in Adolescents with First Episode Early-Onset Psychosis
Background Psychosis is associated with volumetric decreases of cortical structures. Whether these volumetric decreases imply abnormalities in cortical thickness, surface, or cortical folding is not clear. Due to differences in cytoarchitecture, cortical gyri and sulci might be differentially affect...
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| Veröffentlicht in: | Biological psychiatry (1969) 2009-12, Vol.66 (11), p.1047-1054 |
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| creator | Janssen, Joost Reig, Santiago Alemán, Yasser Schnack, Hugo Udias, J.M Parellada, Mara Graell, Montserrat Moreno, Dolores Zabala, Arantzazu Balaban, Evan Desco, Manuel Arango, Celso |
| description | Background Psychosis is associated with volumetric decreases of cortical structures. Whether these volumetric decreases imply abnormalities in cortical thickness, surface, or cortical folding is not clear. Due to differences in cytoarchitecture, cortical gyri and sulci might be differentially affected by psychosis. Therefore, we examined differences in gyral and sulcal cortical thickness, surface, folding, and volume between a minimally treated male adolescent population with early-onset first-episode psychosis (EOP) and a healthy control group, with surface-based morphometry. Methods Magnetic resonance imaging brain scans were obtained from 49 adolescent EOP patients and 34 healthy control subjects. Subjects were younger than 18 years (age range 12 years–18 years), and EOP patients had a duration of positive symptoms of |
| doi_str_mv | 10.1016/j.biopsych.2009.07.021 |
| format | Article |
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Whether these volumetric decreases imply abnormalities in cortical thickness, surface, or cortical folding is not clear. Due to differences in cytoarchitecture, cortical gyri and sulci might be differentially affected by psychosis. Therefore, we examined differences in gyral and sulcal cortical thickness, surface, folding, and volume between a minimally treated male adolescent population with early-onset first-episode psychosis (EOP) and a healthy control group, with surface-based morphometry. Methods Magnetic resonance imaging brain scans were obtained from 49 adolescent EOP patients and 34 healthy control subjects. Subjects were younger than 18 years (age range 12 years–18 years), and EOP patients had a duration of positive symptoms of <6 months. Results Early-onset first-episode psychosis was associated with local bilateral cortical thinning and volume deficits in both the gyri and sulci of the superior temporal cortex and the inferior, middle, medial, and superior prefrontal cortex. In the pars triangularis and opercularis cortex of patients, gyral cortical thickness was thinner, whereas sulcal thickness was not. Patients exhibited cortical thinning together with a decreased degree of cortical folding in the right superior frontal cortex. Conclusions Cortical thinning of both gyri and sulci seem to underlie most cortical volume deficits in adolescent patients with EOP. Except for the right superior frontal region, the degree of cortical folding was normal in regions showing decreased cortical thickness, suggesting that the process of cortical thinning in adolescent patients with EOP primarily takes place after the formation of cortical folds.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/j.biopsych.2009.07.021</identifier><identifier>PMID: 19717139</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescence ; Adolescent ; Age of Onset ; Antipsychotic Agents - therapeutic use ; Biological and medical sciences ; Cerebral Cortex - pathology ; Child ; cortical folding ; cortical thickness ; Humans ; Intelligence ; magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Organ Size ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; psychosis ; Psychotic Disorders - diagnosis ; Psychotic Disorders - drug therapy ; Psychotic Disorders - pathology ; surface-based morphometry ; volume</subject><ispartof>Biological psychiatry (1969), 2009-12, Vol.66 (11), p.1047-1054</ispartof><rights>Society of Biological Psychiatry</rights><rights>2009 Society of Biological Psychiatry</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-f6c24924604df55b68fdf8c416e02dcb5b3a4a752b8edc2bc1ce65b319da882d3</citedby><cites>FETCH-LOGICAL-c514t-f6c24924604df55b68fdf8c416e02dcb5b3a4a752b8edc2bc1ce65b319da882d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006322309008956$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22157751$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19717139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Janssen, Joost</creatorcontrib><creatorcontrib>Reig, Santiago</creatorcontrib><creatorcontrib>Alemán, Yasser</creatorcontrib><creatorcontrib>Schnack, Hugo</creatorcontrib><creatorcontrib>Udias, J.M</creatorcontrib><creatorcontrib>Parellada, Mara</creatorcontrib><creatorcontrib>Graell, Montserrat</creatorcontrib><creatorcontrib>Moreno, Dolores</creatorcontrib><creatorcontrib>Zabala, Arantzazu</creatorcontrib><creatorcontrib>Balaban, Evan</creatorcontrib><creatorcontrib>Desco, Manuel</creatorcontrib><creatorcontrib>Arango, Celso</creatorcontrib><title>Gyral and Sulcal Cortical Thinning in Adolescents with First Episode Early-Onset Psychosis</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Background Psychosis is associated with volumetric decreases of cortical structures. Whether these volumetric decreases imply abnormalities in cortical thickness, surface, or cortical folding is not clear. Due to differences in cytoarchitecture, cortical gyri and sulci might be differentially affected by psychosis. Therefore, we examined differences in gyral and sulcal cortical thickness, surface, folding, and volume between a minimally treated male adolescent population with early-onset first-episode psychosis (EOP) and a healthy control group, with surface-based morphometry. Methods Magnetic resonance imaging brain scans were obtained from 49 adolescent EOP patients and 34 healthy control subjects. Subjects were younger than 18 years (age range 12 years–18 years), and EOP patients had a duration of positive symptoms of <6 months. Results Early-onset first-episode psychosis was associated with local bilateral cortical thinning and volume deficits in both the gyri and sulci of the superior temporal cortex and the inferior, middle, medial, and superior prefrontal cortex. In the pars triangularis and opercularis cortex of patients, gyral cortical thickness was thinner, whereas sulcal thickness was not. Patients exhibited cortical thinning together with a decreased degree of cortical folding in the right superior frontal cortex. Conclusions Cortical thinning of both gyri and sulci seem to underlie most cortical volume deficits in adolescent patients with EOP. Except for the right superior frontal region, the degree of cortical folding was normal in regions showing decreased cortical thickness, suggesting that the process of cortical thinning in adolescent patients with EOP primarily takes place after the formation of cortical folds.</description><subject>Adolescence</subject><subject>Adolescent</subject><subject>Age of Onset</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cerebral Cortex - pathology</subject><subject>Child</subject><subject>cortical folding</subject><subject>cortical thickness</subject><subject>Humans</subject><subject>Intelligence</subject><subject>magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Organ Size</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>psychosis</subject><subject>Psychotic Disorders - diagnosis</subject><subject>Psychotic Disorders - drug therapy</subject><subject>Psychotic Disorders - pathology</subject><subject>surface-based morphometry</subject><subject>volume</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQQC0EokvhL1S5QE8JM3ZiJxdEtdoWpEpFarlwsRzbYb1kncVOQPn3ONoFJA7AyWPrzYf8hpALhAIB-etd0brhEGe9LShAU4AogOIjssJasJyWQB-TFQDwnFHKzsizGHfpKijFp-QMG4ECWbMin27moPpMeZPdT71O4XoIo1uCh63z3vnPmfPZlRl6G7X1Y8y-u3GbXbsQx2xzcHEwNtuo0M_5nY92zD4sQw3RxefkSaf6aF-cznPy8XrzsH6X397dvF9f3ea6wnLMO65p2dCSQ2m6qmp53Zmu1iVyC9TotmqZKpWoaFtbo2mrUVueHrExqq6pYefk8lj3EIavk42j3Ls0at8rb4cpSsFKZJSVNJGv_kpSxJojwP-AUAM2CeRHUIchxmA7eQhur8IsEeQiSu7kT1FyESVByCQqJV6cOkzt3prfaSczCXh5AlRMNrqgvHbxF5c8VkJUS6G3R86mL_7mbJBRO-u1NS5YPUozuH_P8uaPErp3ftmBL3a2cTdMwSeBEmWkEuT9slbLVkEDUDcVZz8AguzJeQ</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Janssen, Joost</creator><creator>Reig, Santiago</creator><creator>Alemán, Yasser</creator><creator>Schnack, Hugo</creator><creator>Udias, J.M</creator><creator>Parellada, Mara</creator><creator>Graell, Montserrat</creator><creator>Moreno, Dolores</creator><creator>Zabala, Arantzazu</creator><creator>Balaban, Evan</creator><creator>Desco, Manuel</creator><creator>Arango, Celso</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20091201</creationdate><title>Gyral and Sulcal Cortical Thinning in Adolescents with First Episode Early-Onset Psychosis</title><author>Janssen, Joost ; Reig, Santiago ; Alemán, Yasser ; Schnack, Hugo ; Udias, J.M ; Parellada, Mara ; Graell, Montserrat ; Moreno, Dolores ; Zabala, Arantzazu ; Balaban, Evan ; Desco, Manuel ; Arango, Celso</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-f6c24924604df55b68fdf8c416e02dcb5b3a4a752b8edc2bc1ce65b319da882d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescence</topic><topic>Adolescent</topic><topic>Age of Onset</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cerebral Cortex - pathology</topic><topic>Child</topic><topic>cortical folding</topic><topic>cortical thickness</topic><topic>Humans</topic><topic>Intelligence</topic><topic>magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Organ Size</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>psychosis</topic><topic>Psychotic Disorders - diagnosis</topic><topic>Psychotic Disorders - drug therapy</topic><topic>Psychotic Disorders - pathology</topic><topic>surface-based morphometry</topic><topic>volume</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Janssen, Joost</creatorcontrib><creatorcontrib>Reig, Santiago</creatorcontrib><creatorcontrib>Alemán, Yasser</creatorcontrib><creatorcontrib>Schnack, Hugo</creatorcontrib><creatorcontrib>Udias, J.M</creatorcontrib><creatorcontrib>Parellada, Mara</creatorcontrib><creatorcontrib>Graell, Montserrat</creatorcontrib><creatorcontrib>Moreno, Dolores</creatorcontrib><creatorcontrib>Zabala, Arantzazu</creatorcontrib><creatorcontrib>Balaban, Evan</creatorcontrib><creatorcontrib>Desco, Manuel</creatorcontrib><creatorcontrib>Arango, Celso</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Janssen, Joost</au><au>Reig, Santiago</au><au>Alemán, Yasser</au><au>Schnack, Hugo</au><au>Udias, J.M</au><au>Parellada, Mara</au><au>Graell, Montserrat</au><au>Moreno, Dolores</au><au>Zabala, Arantzazu</au><au>Balaban, Evan</au><au>Desco, Manuel</au><au>Arango, Celso</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gyral and Sulcal Cortical Thinning in Adolescents with First Episode Early-Onset Psychosis</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>66</volume><issue>11</issue><spage>1047</spage><epage>1054</epage><pages>1047-1054</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Background Psychosis is associated with volumetric decreases of cortical structures. Whether these volumetric decreases imply abnormalities in cortical thickness, surface, or cortical folding is not clear. Due to differences in cytoarchitecture, cortical gyri and sulci might be differentially affected by psychosis. Therefore, we examined differences in gyral and sulcal cortical thickness, surface, folding, and volume between a minimally treated male adolescent population with early-onset first-episode psychosis (EOP) and a healthy control group, with surface-based morphometry. Methods Magnetic resonance imaging brain scans were obtained from 49 adolescent EOP patients and 34 healthy control subjects. Subjects were younger than 18 years (age range 12 years–18 years), and EOP patients had a duration of positive symptoms of <6 months. Results Early-onset first-episode psychosis was associated with local bilateral cortical thinning and volume deficits in both the gyri and sulci of the superior temporal cortex and the inferior, middle, medial, and superior prefrontal cortex. In the pars triangularis and opercularis cortex of patients, gyral cortical thickness was thinner, whereas sulcal thickness was not. Patients exhibited cortical thinning together with a decreased degree of cortical folding in the right superior frontal cortex. Conclusions Cortical thinning of both gyri and sulci seem to underlie most cortical volume deficits in adolescent patients with EOP. Except for the right superior frontal region, the degree of cortical folding was normal in regions showing decreased cortical thickness, suggesting that the process of cortical thinning in adolescent patients with EOP primarily takes place after the formation of cortical folds.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>19717139</pmid><doi>10.1016/j.biopsych.2009.07.021</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescence Adolescent Age of Onset Antipsychotic Agents - therapeutic use Biological and medical sciences Cerebral Cortex - pathology Child cortical folding cortical thickness Humans Intelligence magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical sciences Organ Size Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry psychosis Psychotic Disorders - diagnosis Psychotic Disorders - drug therapy Psychotic Disorders - pathology surface-based morphometry volume |
| title | Gyral and Sulcal Cortical Thinning in Adolescents with First Episode Early-Onset Psychosis |
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