The synergistic effects of lysophosphatidic acid receptor agonists and calcitriol on MG63 osteoblast maturation at titanium and hydroxyapatite surfaces
Abstract Successful osseointegration stems from the provision of a mechanically competent mineralised matrix at the implant site. Mature osteoblasts are the cells responsible for achieving this and a key factor for ensuring healthy bone tissue is associated with prosthetic materials will be 1α,25 di...
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| Veröffentlicht in: | Biomaterials 2010-01, Vol.31 (2), p.199-206 |
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| creator | Mansell, Jason P Barbour, Michele Moore, Christopher Nowghani, Maryam Pabbruwe, Moreica Sjostrom, Terje Blom, Ashley W |
| description | Abstract Successful osseointegration stems from the provision of a mechanically competent mineralised matrix at the implant site. Mature osteoblasts are the cells responsible for achieving this and a key factor for ensuring healthy bone tissue is associated with prosthetic materials will be 1α,25 dihydroxy vitamin D3 (calcitriol). However it is known that calcitriol per se does not promote osteoblast maturation, rather the osteoblasts need to be in receipt of calcitriol in combination with selected growth factors in order to undergo a robust maturation response. Herein we report how agonists of the lysophosphatidic acid (LPA) receptor, LPA and (2S)-OMPT, synergistically co-operate with calcitriol to secure osteoblast maturation for cells grown upon two widely used bone biomaterials, titanium and hydroxyapatite. Efforts could now be focussed on functionalising these materials with LPA receptor agonists to support in vivo calcitriol-induced osseointegration via heightened osteoblast maturation responses. |
| doi_str_mv | 10.1016/j.biomaterials.2009.09.035 |
| format | Article |
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Mature osteoblasts are the cells responsible for achieving this and a key factor for ensuring healthy bone tissue is associated with prosthetic materials will be 1α,25 dihydroxy vitamin D3 (calcitriol). However it is known that calcitriol per se does not promote osteoblast maturation, rather the osteoblasts need to be in receipt of calcitriol in combination with selected growth factors in order to undergo a robust maturation response. Herein we report how agonists of the lysophosphatidic acid (LPA) receptor, LPA and (2S)-OMPT, synergistically co-operate with calcitriol to secure osteoblast maturation for cells grown upon two widely used bone biomaterials, titanium and hydroxyapatite. 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Mature osteoblasts are the cells responsible for achieving this and a key factor for ensuring healthy bone tissue is associated with prosthetic materials will be 1α,25 dihydroxy vitamin D3 (calcitriol). However it is known that calcitriol per se does not promote osteoblast maturation, rather the osteoblasts need to be in receipt of calcitriol in combination with selected growth factors in order to undergo a robust maturation response. Herein we report how agonists of the lysophosphatidic acid (LPA) receptor, LPA and (2S)-OMPT, synergistically co-operate with calcitriol to secure osteoblast maturation for cells grown upon two widely used bone biomaterials, titanium and hydroxyapatite. Efforts could now be focussed on functionalising these materials with LPA receptor agonists to support in vivo calcitriol-induced osseointegration via heightened osteoblast maturation responses.</description><subject>Advanced Basic Science</subject><subject>Albumins - metabolism</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Calcitriol</subject><subject>Calcitriol - pharmacology</subject><subject>Cell culture</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Line</subject><subject>Dentistry</subject><subject>Durapatite - pharmacology</subject><subject>Humans</subject><subject>Hydroxyapatite</subject><subject>Lysophosphatidic acid receptor agonists</subject><subject>Lysophospholipids - pharmacology</subject><subject>Organothiophosphates - pharmacology</subject><subject>Osteoblast maturation</subject><subject>Osteoblasts - cytology</subject><subject>Osteoblasts - drug effects</subject><subject>Osteoblasts - ultrastructure</subject><subject>Phosphatidic Acids - pharmacology</subject><subject>Receptors, Lysophosphatidic Acid - agonists</subject><subject>Surface Properties - drug effects</subject><subject>Titanium</subject><subject>Titanium - pharmacology</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUt2K1DAULqK44-orSPBCrzrmp0kbLwRZdRVWvHAF70KanOxk7DQ1ScU-ia9r6gwoXqhwIITv55zkO1X1iOAtwUQ83W97Hw46Q_R6SFuKsdyuxfitakO6tqu5xPx2tcGkobUUhJ5V91La43LHDb1bnRHZStFhuam-X-8ApWWEeONT9gaBc2ByQsGhYUlh2oU07XT2tmDaeIsiGJhyiEjfhLFoEtKjRUYPxufow4DCiN5dCoZCyhD6QaeMyrBzLCYF0hlln_Xo58NP4W6xMXxb9FTgXEaZo9MG0v3qjiuPgwen87z6-PrV9cWb-ur95duLF1e14YLmugfoCSEaU9e1RjvbckpbwQXrMAXXNLqjLReuwdJqQRzvpSat5obb3jBi2Hn15Og7xfBlhpTVwScDw6BHCHNSLWsII5S1hfn4r0wmqMSMin8SKSGYY4IL8dmRaGJIKYJTU_QHHRdFsFqTVnv1e9JqTVqtxXgRPzx1mfsD2F_SU7SF8PJIgPJ9Xz1ElYyH0YD1JcKsbPD_1-f5HzZm8KMveX-GBdI-zHFcNUQlqrD6sO7cunJYFhPBP7EfdszZ8w</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Mansell, Jason P</creator><creator>Barbour, Michele</creator><creator>Moore, Christopher</creator><creator>Nowghani, Maryam</creator><creator>Pabbruwe, Moreica</creator><creator>Sjostrom, Terje</creator><creator>Blom, Ashley W</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20100101</creationdate><title>The synergistic effects of lysophosphatidic acid receptor agonists and calcitriol on MG63 osteoblast maturation at titanium and hydroxyapatite surfaces</title><author>Mansell, Jason P ; Barbour, Michele ; Moore, Christopher ; Nowghani, Maryam ; Pabbruwe, Moreica ; Sjostrom, Terje ; Blom, Ashley W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-beeb111a02f87cafd752276563802ef44a82756f409da61f5b9a17a5c5dbc31c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Advanced Basic Science</topic><topic>Albumins - metabolism</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Calcitriol</topic><topic>Calcitriol - pharmacology</topic><topic>Cell culture</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Line</topic><topic>Dentistry</topic><topic>Durapatite - pharmacology</topic><topic>Humans</topic><topic>Hydroxyapatite</topic><topic>Lysophosphatidic acid receptor agonists</topic><topic>Lysophospholipids - pharmacology</topic><topic>Organothiophosphates - pharmacology</topic><topic>Osteoblast maturation</topic><topic>Osteoblasts - cytology</topic><topic>Osteoblasts - drug effects</topic><topic>Osteoblasts - ultrastructure</topic><topic>Phosphatidic Acids - pharmacology</topic><topic>Receptors, Lysophosphatidic Acid - agonists</topic><topic>Surface Properties - drug effects</topic><topic>Titanium</topic><topic>Titanium - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mansell, Jason P</creatorcontrib><creatorcontrib>Barbour, Michele</creatorcontrib><creatorcontrib>Moore, Christopher</creatorcontrib><creatorcontrib>Nowghani, Maryam</creatorcontrib><creatorcontrib>Pabbruwe, Moreica</creatorcontrib><creatorcontrib>Sjostrom, Terje</creatorcontrib><creatorcontrib>Blom, Ashley W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mansell, Jason P</au><au>Barbour, Michele</au><au>Moore, Christopher</au><au>Nowghani, Maryam</au><au>Pabbruwe, Moreica</au><au>Sjostrom, Terje</au><au>Blom, Ashley W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The synergistic effects of lysophosphatidic acid receptor agonists and calcitriol on MG63 osteoblast maturation at titanium and hydroxyapatite surfaces</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>31</volume><issue>2</issue><spage>199</spage><epage>206</epage><pages>199-206</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Abstract Successful osseointegration stems from the provision of a mechanically competent mineralised matrix at the implant site. 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| ispartof | Biomaterials, 2010-01, Vol.31 (2), p.199-206 |
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| subjects | Advanced Basic Science Albumins - metabolism Biocompatible Materials - pharmacology Calcitriol Calcitriol - pharmacology Cell culture Cell Differentiation - drug effects Cell Line Dentistry Durapatite - pharmacology Humans Hydroxyapatite Lysophosphatidic acid receptor agonists Lysophospholipids - pharmacology Organothiophosphates - pharmacology Osteoblast maturation Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - ultrastructure Phosphatidic Acids - pharmacology Receptors, Lysophosphatidic Acid - agonists Surface Properties - drug effects Titanium Titanium - pharmacology |
| title | The synergistic effects of lysophosphatidic acid receptor agonists and calcitriol on MG63 osteoblast maturation at titanium and hydroxyapatite surfaces |
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