(13)C breath tests in personalized medicine: fiction or reality?
The concept of personalized medicine is gathering momentum as various biomarkers are being discovered and developed to lead to genotype and phenotype diagnostic tests, which will enable physicians to individualize therapy. Noninvasive, rapid (13)C breath tests have the potential to serve as clinical...
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| Veröffentlicht in: | Expert review of molecular diagnostics 2009-11, Vol.9 (8), p.805-815 |
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| container_title | Expert review of molecular diagnostics |
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| creator | Modak, Anil S |
| description | The concept of personalized medicine is gathering momentum as various biomarkers are being discovered and developed to lead to genotype and phenotype diagnostic tests, which will enable physicians to individualize therapy. Noninvasive, rapid (13)C breath tests have the potential to serve as clinically significant diagnostic tools, especially for evaluating the enzyme activity of polymorphic enzymes. This would enable physicians to rapidly identify responders/nonresponders to various drugs primarily metabolized by these enzymes prior to initiation of therapy. With the information on enzyme activity, the physician can prescribe the right drug, at the right dose, at the right time, to the right individual, for the right clinical outcome. However, the promise of the era of personalized medicine, including the novel (13)C breath tests, will have to overcome several regulatory, business and financial hurdles for diagnostic tests to become part of routine mainstream clinical practice over the next decade. |
| doi_str_mv | 10.1586/erm.09.58 |
| format | Article |
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| identifier | EISSN: 1744-8352 |
| ispartof | Expert review of molecular diagnostics, 2009-11, Vol.9 (8), p.805-815 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | 2-Pyridinylmethylsulfinylbenzimidazoles - metabolism Acetamides - metabolism Anti-Ulcer Agents - metabolism Antitussive Agents - metabolism Biomarkers - metabolism Breath Tests Carbon Isotopes - metabolism Cytochrome P-450 Enzyme System - metabolism Dextromethorphan - metabolism Drug Approval Drug Design Humans Pharmacogenetics Practice Patterns, Physicians Precision Medicine United States United States Food and Drug Administration |
| title | (13)C breath tests in personalized medicine: fiction or reality? |
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