Meta-analysis of risk factors for cutaneous melanoma according to anatomical site and clinico-pathological variant
Abstract A systematic meta-analysis was performed to evaluate if cutaneous melanoma (CM) risk factors differ depending on body site and histological type. Adjusted estimates were extracted from 24 observational studies, for a total of 16,180 cases. Multivariate random-effects models were used to obt...
Gespeichert in:
| Veröffentlicht in: | European journal of cancer (1990) 2009-11, Vol.45 (17), p.3054-3063 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3063 |
|---|---|
| container_issue | 17 |
| container_start_page | 3054 |
| container_title | European journal of cancer (1990) |
| container_volume | 45 |
| creator | Caini, Saverio Gandini, Sara Sera, Francesco Raimondi, Sara Fargnoli, Maria Concetta Boniol, Mathieu Armstrong, Bruce K |
| description | Abstract A systematic meta-analysis was performed to evaluate if cutaneous melanoma (CM) risk factors differ depending on body site and histological type. Adjusted estimates were extracted from 24 observational studies, for a total of 16,180 cases. Multivariate random-effects models were used to obtain summary relative risk (RR) estimates for all risk factors by body site and histological type. Summary RRs suggest that high naevus counts are strongly associated with CM on usually not sun exposed sites ( p < 0.001) while different patterns of sun exposure show a tendency for higher RRs for CM on usually sun exposed sites than on other body sites ( p = 0.087). Continuous pattern was found to be significantly inversely associated with CM for unexposed sites ( p = 0.01). RRs also differed by body site for skin ( p = 0.01) and hair colour ( p = 0.01), and these differences could be attributed to gene variability. This finding seems to suggest different aetiologic pathways of melanoma development by anatomical site. |
| doi_str_mv | 10.1016/j.ejca.2009.05.009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734129064</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0959804909003499</els_id><sourcerecordid>734129064</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-91d72cae165c35b63a62572c9506b5c2f4666221cc4f36803a1fa6d9fae6c7e33</originalsourceid><addsrcrecordid>eNp9kkFv1DAQhSMEotvCH-CAfAFOCWMndmIJVUIVBaQiDsDZmp04xWkSL7a30v57HHYFEoeeRra_NxrPe0XxgkPFgau3Y2VHwkoA6ApklcujYsO7VpfQSfG42ICWuuyg0WfFeYwjALRdA0-LM65lI7VuN0X4YhOWuOB0iC4yP7Dg4h0bkJIPkQ0-MNonXKzfRzbbCRc_I0MiH3q33LLkWRYnPzvCiUWXbD73jCa3OPLlDtNPP_nbP6_3GBwu6VnxZMAp2uenelH8uP7w_epTefP14-er9zclNS1PpeZ9KwgtV5JquVU1KiHzjZagtpLE0CilhOBEzVCrDmrkA6peD2gVtbauL4o3x7674H_tbUxmdpHsNB1_Y9q64UKDajL5-kFScN51ivMMiiNIwccY7GB2wc0YDoaDWT0xo1k9MasnBqTJJYtenrrvt7Pt_0lOJmTg1QnAmPc0BFzIxb-cELkbiHXMd0fO5q3dOxtMJGcXsr0LlpLpvXt4jsv_5EeXcLqzBxtHvw85BtFwE4UB821Nzxoe0AB1o3X9GwYUwEE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21188611</pqid></control><display><type>article</type><title>Meta-analysis of risk factors for cutaneous melanoma according to anatomical site and clinico-pathological variant</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Caini, Saverio ; Gandini, Sara ; Sera, Francesco ; Raimondi, Sara ; Fargnoli, Maria Concetta ; Boniol, Mathieu ; Armstrong, Bruce K</creator><creatorcontrib>Caini, Saverio ; Gandini, Sara ; Sera, Francesco ; Raimondi, Sara ; Fargnoli, Maria Concetta ; Boniol, Mathieu ; Armstrong, Bruce K</creatorcontrib><description>Abstract A systematic meta-analysis was performed to evaluate if cutaneous melanoma (CM) risk factors differ depending on body site and histological type. Adjusted estimates were extracted from 24 observational studies, for a total of 16,180 cases. Multivariate random-effects models were used to obtain summary relative risk (RR) estimates for all risk factors by body site and histological type. Summary RRs suggest that high naevus counts are strongly associated with CM on usually not sun exposed sites ( p < 0.001) while different patterns of sun exposure show a tendency for higher RRs for CM on usually sun exposed sites than on other body sites ( p = 0.087). Continuous pattern was found to be significantly inversely associated with CM for unexposed sites ( p = 0.01). RRs also differed by body site for skin ( p = 0.01) and hair colour ( p = 0.01), and these differences could be attributed to gene variability. This finding seems to suggest different aetiologic pathways of melanoma development by anatomical site.</description><identifier>ISSN: 0959-8049</identifier><identifier>EISSN: 1879-0852</identifier><identifier>DOI: 10.1016/j.ejca.2009.05.009</identifier><identifier>PMID: 19545997</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Body site ; Epidemiology ; Hair Color ; Hematology, Oncology and Palliative Medicine ; Humans ; Medical sciences ; Melanoma ; Melanoma - etiology ; Melanoma - pathology ; Meta-analysis ; Naevus ; Neoplasm by site ; Neoplasms by histologic type ; Neoplasms, Radiation-Induced - etiology ; Neoplasms, Radiation-Induced - pathology ; Pharmacology. Drug treatments ; Phenotype ; Risk Factors ; Skin Neoplasms - etiology ; Skin Neoplasms - pathology ; Skin Pigmentation ; Sun exposure ; Sunlight - adverse effects ; Tumors</subject><ispartof>European journal of cancer (1990), 2009-11, Vol.45 (17), p.3054-3063</ispartof><rights>Elsevier Ltd</rights><rights>2009 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-91d72cae165c35b63a62572c9506b5c2f4666221cc4f36803a1fa6d9fae6c7e33</citedby><cites>FETCH-LOGICAL-c471t-91d72cae165c35b63a62572c9506b5c2f4666221cc4f36803a1fa6d9fae6c7e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejca.2009.05.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22200024$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19545997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caini, Saverio</creatorcontrib><creatorcontrib>Gandini, Sara</creatorcontrib><creatorcontrib>Sera, Francesco</creatorcontrib><creatorcontrib>Raimondi, Sara</creatorcontrib><creatorcontrib>Fargnoli, Maria Concetta</creatorcontrib><creatorcontrib>Boniol, Mathieu</creatorcontrib><creatorcontrib>Armstrong, Bruce K</creatorcontrib><title>Meta-analysis of risk factors for cutaneous melanoma according to anatomical site and clinico-pathological variant</title><title>European journal of cancer (1990)</title><addtitle>Eur J Cancer</addtitle><description>Abstract A systematic meta-analysis was performed to evaluate if cutaneous melanoma (CM) risk factors differ depending on body site and histological type. Adjusted estimates were extracted from 24 observational studies, for a total of 16,180 cases. Multivariate random-effects models were used to obtain summary relative risk (RR) estimates for all risk factors by body site and histological type. Summary RRs suggest that high naevus counts are strongly associated with CM on usually not sun exposed sites ( p < 0.001) while different patterns of sun exposure show a tendency for higher RRs for CM on usually sun exposed sites than on other body sites ( p = 0.087). Continuous pattern was found to be significantly inversely associated with CM for unexposed sites ( p = 0.01). RRs also differed by body site for skin ( p = 0.01) and hair colour ( p = 0.01), and these differences could be attributed to gene variability. This finding seems to suggest different aetiologic pathways of melanoma development by anatomical site.</description><subject>Biological and medical sciences</subject><subject>Body site</subject><subject>Epidemiology</subject><subject>Hair Color</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Melanoma</subject><subject>Melanoma - etiology</subject><subject>Melanoma - pathology</subject><subject>Meta-analysis</subject><subject>Naevus</subject><subject>Neoplasm by site</subject><subject>Neoplasms by histologic type</subject><subject>Neoplasms, Radiation-Induced - etiology</subject><subject>Neoplasms, Radiation-Induced - pathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenotype</subject><subject>Risk Factors</subject><subject>Skin Neoplasms - etiology</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Pigmentation</subject><subject>Sun exposure</subject><subject>Sunlight - adverse effects</subject><subject>Tumors</subject><issn>0959-8049</issn><issn>1879-0852</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kkFv1DAQhSMEotvCH-CAfAFOCWMndmIJVUIVBaQiDsDZmp04xWkSL7a30v57HHYFEoeeRra_NxrPe0XxgkPFgau3Y2VHwkoA6ApklcujYsO7VpfQSfG42ICWuuyg0WfFeYwjALRdA0-LM65lI7VuN0X4YhOWuOB0iC4yP7Dg4h0bkJIPkQ0-MNonXKzfRzbbCRc_I0MiH3q33LLkWRYnPzvCiUWXbD73jCa3OPLlDtNPP_nbP6_3GBwu6VnxZMAp2uenelH8uP7w_epTefP14-er9zclNS1PpeZ9KwgtV5JquVU1KiHzjZagtpLE0CilhOBEzVCrDmrkA6peD2gVtbauL4o3x7674H_tbUxmdpHsNB1_Y9q64UKDajL5-kFScN51ivMMiiNIwccY7GB2wc0YDoaDWT0xo1k9MasnBqTJJYtenrrvt7Pt_0lOJmTg1QnAmPc0BFzIxb-cELkbiHXMd0fO5q3dOxtMJGcXsr0LlpLpvXt4jsv_5EeXcLqzBxtHvw85BtFwE4UB821Nzxoe0AB1o3X9GwYUwEE</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Caini, Saverio</creator><creator>Gandini, Sara</creator><creator>Sera, Francesco</creator><creator>Raimondi, Sara</creator><creator>Fargnoli, Maria Concetta</creator><creator>Boniol, Mathieu</creator><creator>Armstrong, Bruce K</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Meta-analysis of risk factors for cutaneous melanoma according to anatomical site and clinico-pathological variant</title><author>Caini, Saverio ; Gandini, Sara ; Sera, Francesco ; Raimondi, Sara ; Fargnoli, Maria Concetta ; Boniol, Mathieu ; Armstrong, Bruce K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-91d72cae165c35b63a62572c9506b5c2f4666221cc4f36803a1fa6d9fae6c7e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Body site</topic><topic>Epidemiology</topic><topic>Hair Color</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Melanoma</topic><topic>Melanoma - etiology</topic><topic>Melanoma - pathology</topic><topic>Meta-analysis</topic><topic>Naevus</topic><topic>Neoplasm by site</topic><topic>Neoplasms by histologic type</topic><topic>Neoplasms, Radiation-Induced - etiology</topic><topic>Neoplasms, Radiation-Induced - pathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenotype</topic><topic>Risk Factors</topic><topic>Skin Neoplasms - etiology</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Pigmentation</topic><topic>Sun exposure</topic><topic>Sunlight - adverse effects</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caini, Saverio</creatorcontrib><creatorcontrib>Gandini, Sara</creatorcontrib><creatorcontrib>Sera, Francesco</creatorcontrib><creatorcontrib>Raimondi, Sara</creatorcontrib><creatorcontrib>Fargnoli, Maria Concetta</creatorcontrib><creatorcontrib>Boniol, Mathieu</creatorcontrib><creatorcontrib>Armstrong, Bruce K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cancer (1990)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caini, Saverio</au><au>Gandini, Sara</au><au>Sera, Francesco</au><au>Raimondi, Sara</au><au>Fargnoli, Maria Concetta</au><au>Boniol, Mathieu</au><au>Armstrong, Bruce K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Meta-analysis of risk factors for cutaneous melanoma according to anatomical site and clinico-pathological variant</atitle><jtitle>European journal of cancer (1990)</jtitle><addtitle>Eur J Cancer</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>45</volume><issue>17</issue><spage>3054</spage><epage>3063</epage><pages>3054-3063</pages><issn>0959-8049</issn><eissn>1879-0852</eissn><abstract>Abstract A systematic meta-analysis was performed to evaluate if cutaneous melanoma (CM) risk factors differ depending on body site and histological type. Adjusted estimates were extracted from 24 observational studies, for a total of 16,180 cases. Multivariate random-effects models were used to obtain summary relative risk (RR) estimates for all risk factors by body site and histological type. Summary RRs suggest that high naevus counts are strongly associated with CM on usually not sun exposed sites ( p < 0.001) while different patterns of sun exposure show a tendency for higher RRs for CM on usually sun exposed sites than on other body sites ( p = 0.087). Continuous pattern was found to be significantly inversely associated with CM for unexposed sites ( p = 0.01). RRs also differed by body site for skin ( p = 0.01) and hair colour ( p = 0.01), and these differences could be attributed to gene variability. This finding seems to suggest different aetiologic pathways of melanoma development by anatomical site.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>19545997</pmid><doi>10.1016/j.ejca.2009.05.009</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-8049 |
| ispartof | European journal of cancer (1990), 2009-11, Vol.45 (17), p.3054-3063 |
| issn | 0959-8049 1879-0852 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734129064 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Biological and medical sciences Body site Epidemiology Hair Color Hematology, Oncology and Palliative Medicine Humans Medical sciences Melanoma Melanoma - etiology Melanoma - pathology Meta-analysis Naevus Neoplasm by site Neoplasms by histologic type Neoplasms, Radiation-Induced - etiology Neoplasms, Radiation-Induced - pathology Pharmacology. Drug treatments Phenotype Risk Factors Skin Neoplasms - etiology Skin Neoplasms - pathology Skin Pigmentation Sun exposure Sunlight - adverse effects Tumors |
| title | Meta-analysis of risk factors for cutaneous melanoma according to anatomical site and clinico-pathological variant |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T08%3A47%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Meta-analysis%20of%20risk%20factors%20for%20cutaneous%20melanoma%20according%20to%20anatomical%20site%20and%20clinico-pathological%20variant&rft.jtitle=European%20journal%20of%20cancer%20(1990)&rft.au=Caini,%20Saverio&rft.date=2009-11-01&rft.volume=45&rft.issue=17&rft.spage=3054&rft.epage=3063&rft.pages=3054-3063&rft.issn=0959-8049&rft.eissn=1879-0852&rft_id=info:doi/10.1016/j.ejca.2009.05.009&rft_dat=%3Cproquest_cross%3E734129064%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=21188611&rft_id=info:pmid/19545997&rft_els_id=S0959804909003499&rfr_iscdi=true |