Characteristics of EPI-hNE4 aerosol: A new elastase inhibitor for treatment of cystic fibrosis

The purpose of this study was to define nebulization conditions providing delivery of aerosols of EPI-hNE4, an inhibitor of human neutrophil elastase (HNE). EPI-hNE4 was nebulized with Pari LC Star and tested at three concentrations (2.5, 5, and 10 mg/mL). The inhaled mass was measured over 15 min....

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Veröffentlicht in:	Journal of aerosol medicine 2003-06, Vol.16 (2), p.121-129
Hauptverfasser:	GRIMBERT, D, VECELLIO, L, DIOT, P, DELEPINE, P, ATTUCCI, S, BOISSINOT, E, PONCIN, A, GAUTHIER, F, VALAT, C, SAUDUBRAY, F, ANTONIOZ, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Aerosols Biological and medical sciences Cystic Fibrosis - drug therapy Equipment Design General pharmacology Health technology assessment Humans Linear Models Medical sciences Nebulizers and Vaporizers Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Proteins - administration & dosage Respiratory system Serpins
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