Gene Therapy With the Angiogenic Cytokine Secretoneurin Induces Therapeutic Angiogenesis by a Nitric Oxide–Dependent Mechanism

RATIONALE:The neuropeptide secretoneurin induces angiogenesis and postnatal vasculogenesis and is upregulated by hypoxia in skeletal muscle cells. OBJECTIVE:We sought to investigate the effects of secretoneurin on therapeutic angiogenesis. METHODS AND RESULTS:We generated a secretoneurin gene therap...

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Veröffentlicht in:	Circulation research 2009-11, Vol.105 (10), p.994-1002
Hauptverfasser:	Schgoer, Wilfried, Theurl, Markus, Jeschke, Johannes, Beer, Arno G.E, Albrecht, Karin, Gander, Roland, Rong, Song, Vasiljevic, Danijela, Egger, Margot, Wolf, Anna Maria, Frauscher, Silke, Koller, Bernhard, Tancevski, Ivan, Patsch, Josef R, Schratzberger, Peter, Piza-Katzer, Hildegunde, Ritsch, Andreas, Bahlmann, Ferdinand H, Fischer-Colbrie, Reiner, Wolf, Dominik, Kirchmair, Rudolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inducing Agents - metabolism Animals Biological and medical sciences Cytokines - biosynthesis Cytokines - genetics Disease Models, Animal Endothelial Cells - metabolism Fundamental and applied biological sciences. Psychology Genetic Therapy Hindlimb - blood supply Hindlimb - metabolism Humans Ischemia - genetics Ischemia - metabolism Ischemia - therapy Mice Neovascularization, Physiologic Neuropeptides - biosynthesis Neuropeptides - genetics Nitric Oxide - metabolism Nitric Oxide Synthase Type III - biosynthesis Secretogranin II - biosynthesis Secretogranin II - genetics Stem Cells - metabolism Vertebrates: cardiovascular system
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