A Photocontrolled Molecular Switch Regulates Paralysis in a Living Organism
Using light to modulate biochemical agents in living organisms has a significant impact on photodynamic therapy and drug release. We demonstrate that a photoresponsive system can reversibly induce paralysis in nematodes as a model for living organisms when two different wavelengths of light are used...
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| Veröffentlicht in: | Journal of the American Chemical Society 2009-11, Vol.131 (44), p.15966-15967 |
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| container_end_page | 15967 |
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| container_issue | 44 |
| container_start_page | 15966 |
| container_title | Journal of the American Chemical Society |
| container_volume | 131 |
| creator | Al-Atar, Usama Fernandes, Rylan Johnsen, Bob Baillie, David Branda, Neil R. |
| description | Using light to modulate biochemical agents in living organisms has a significant impact on photodynamic therapy and drug release. We demonstrate that a photoresponsive system can reversibly induce paralysis in nematodes as a model for living organisms when two different wavelengths of light are used to toggle the molecular switch between its two structural forms. This example illustrates how photoswitches offer great potential for advancing biomedical technologies. |
| doi_str_mv | 10.1021/ja903070u |
| format | Article |
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| ispartof | Journal of the American Chemical Society, 2009-11, Vol.131 (44), p.15966-15967 |
| issn | 0002-7863 1520-5126 |
| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Animals Caenorhabditis elegans - drug effects Cyclization - radiation effects Ethylenes - pharmacology Ethylenes - radiation effects Light Models, Animal Paralysis - drug therapy Photochemotherapy - methods |
| title | A Photocontrolled Molecular Switch Regulates Paralysis in a Living Organism |
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