Pioglitazone Treatment Enlarges Subcutaneous Adipocytes in Insulin-Resistant Patients

Context: Obesity-related insulin resistance is associated with an increase in adipocyte size. In rodent models, treatment with the insulin-sensitizers thiazolidinediones (TZDs) leads to the appearance of small, insulin-sensitive adipocytes. Whether such TZD-dependent morphological changes occur in a...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2009-11, Vol.94 (11), p.4453-4457
Hauptverfasser:	Koenen, Tim B., Tack, Cees J., Kroese, Jeanne Margot, Hermus, Ad R., Sweep, Fred C. G., van der Laak, Jeroen, Stalenhoef, Anton F. H., de Graaf, Jacqueline, van Tits, Lambertus J. H., Stienstra, Rinke
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - drug effects Adipocytes - pathology Adrenal Hyperplasia, Congenital - drug therapy Adrenal Hyperplasia, Congenital - pathology Adult Biological and medical sciences Cross-Over Studies Endocrinopathies Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Glucose Clamp Technique - methods Humans Hypoglycemic Agents - pharmacology Insulin Resistance - physiology Medical sciences Obesity - pathology Placebos Thiazolidinediones - therapeutic use Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology
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