Recombinant human growth hormone improves survival and protects against acute lung injury in murine Staphylococcus aureus sepsis

Objective To investigate whether recombinant human growth hormone (rhGH) reduces mortality and protects against Staphylococcus aureus sepsis-induced acute lung injury. Methods The bacteria-positive rate of blood smears and bacteria colony counts in bacteria plate culture, TNFα and IL-10 plasma level...

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Veröffentlicht in:	Inflammation research 2009-12, Vol.58 (12), p.855-862
Hauptverfasser:	Yi, C, Cao, Y, Mao, S. H, Liu, H, Ji, L. L, Xu, S. Y, Zhang, M, Huang, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - immunology Acute Lung Injury - pathology Acute Lung Injury - prevention & control Allergology Animals Biomedical and Life Sciences Biomedicine Dermatology Human Growth Hormone - genetics Human Growth Hormone - metabolism Human Growth Hormone - therapeutic use Humans Immunology Intercellular Adhesion Molecule-1 - metabolism Interleukin-10 - blood Interleukin-10 - immunology Lung - cytology Lung - metabolism Lung - microbiology Lung - pathology Mice Neurology NF-kappa B - metabolism Original Research Paper Pharmacology/Toxicology Random Allocation Recombinant Proteins - genetics Recombinant Proteins - metabolism Recombinant Proteins - therapeutic use Rheumatology Sepsis - drug therapy Sepsis - immunology Sepsis - microbiology Sepsis - pathology Staphylococcal Infections - drug therapy Staphylococcal Infections - immunology Staphylococcal Infections - pathology Staphylococcus aureus Staphylococcus aureus - pathogenicity Survival Rate Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - immunology
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