Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Reverses Mesenchymal to Epithelial Phenotype and Inhibits Metastasis in Inflammatory Breast Cancer

Purpose: Inflammatory breast cancer (IBC) is a rare but aggressive type of advanced breast cancer. Epidermal growth factor receptor (EGFR) expression is an independent poor prognostic factor in IBC. The purpose of this study was to determine the effect on IBC tumorigenicity and metastasis of blockin...

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Veröffentlicht in:	Clinical cancer research 2009-11, Vol.15 (21), p.6639-6648
Hauptverfasser:	Zhang, Dongwei, LaFortune, Tiffany A, Krishnamurthy, Savitri, Esteva, Francisco J, Cristofanilli, Massimo, Liu, Ping, Lucci, Anthony, Singh, Balraj, Hung, Mien-Chie, Hortobagyi, Gabriel N, Ueno, Naoto T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Animals Antineoplastic Agents - pharmacology Breast Neoplasms - drug therapy Cell Differentiation Cell Line, Tumor EGFR Epithelium - metabolism erlotinib Erlotinib Hydrochloride Humans Inflammation - drug therapy inflammatory breast cancer Lung Neoplasms - prevention & control Lung Neoplasms - secondary Male Mesoderm - metabolism metastasis Mice Mice, Nude Protein Kinase Inhibitors - pharmacology Quinazolines - pharmacology Receptor, Epidermal Growth Factor - antagonists & inhibitors RNA, Small Interfering - pharmacology Signal Transduction tyrosine kinase inhibitor
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