Composite microparticles with in vivo reduction of the burst release effect
The aim of this study was to develop microparticles containing nanoparticles (composite microparticles) for prolonged drug delivery with reduced burst effect in vitro and in vivo. Such composite microparticles were prepared with hydrophobic and biodegradable polymers [poly(ε-caprolactone), poly(lact...
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| Veröffentlicht in: | European journal of pharmaceutics and biopharmaceutics 2009-11, Vol.73 (3), p.337-344 |
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| container_title | European journal of pharmaceutics and biopharmaceutics |
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| creator | Sheikh Hassan, A. Sapin, A. Lamprecht, A. Emond, E. El Ghazouani, F. Maincent, P. |
| description | The aim of this study was to develop microparticles containing nanoparticles (composite microparticles) for prolonged drug delivery with reduced burst effect
in vitro and
in vivo. Such composite microparticles were prepared with hydrophobic and biodegradable polymers [poly(ε-caprolactone), poly(lactic-co-glycolic) acid]. Ibuprofen was chosen as the model drug, and microparticles were prepared by the extraction technique with ethyl acetate as the solvent. Nanoparticles and microparticles and an ibuprofen solution (Pedea
®) were administered subcutaneously at the dose of 1
mg of ibuprofen per kg to overnight-fasted rats (male Wistar). Composite microparticles showed prolonged ibuprofen release and less burst effect when compared to simple microparticles (without nanoparticles inside) or nanoparticles both
in vitro (PBS buffer) and
in vivo. Moreover, ibuprofen was still detected in the plasma after 96
h with composite microparticles. Consequently, it has been demonstrated that composite microparticles were able to reduce burst release and prolong the release of ibuprofen for a long period of time. |
| doi_str_mv | 10.1016/j.ejpb.2009.07.009 |
| format | Article |
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in vitro and
in vivo. Such composite microparticles were prepared with hydrophobic and biodegradable polymers [poly(ε-caprolactone), poly(lactic-co-glycolic) acid]. Ibuprofen was chosen as the model drug, and microparticles were prepared by the extraction technique with ethyl acetate as the solvent. Nanoparticles and microparticles and an ibuprofen solution (Pedea
®) were administered subcutaneously at the dose of 1
mg of ibuprofen per kg to overnight-fasted rats (male Wistar). Composite microparticles showed prolonged ibuprofen release and less burst effect when compared to simple microparticles (without nanoparticles inside) or nanoparticles both
in vitro (PBS buffer) and
in vivo. Moreover, ibuprofen was still detected in the plasma after 96
h with composite microparticles. Consequently, it has been demonstrated that composite microparticles were able to reduce burst release and prolong the release of ibuprofen for a long period of time.</description><identifier>ISSN: 0939-6411</identifier><identifier>EISSN: 1873-3441</identifier><identifier>DOI: 10.1016/j.ejpb.2009.07.009</identifier><identifier>PMID: 19651210</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics ; Biological and medical sciences ; Burst effect ; Chemistry, Pharmaceutical ; Composite microparticles ; Delayed-Action Preparations ; Drug Carriers - chemistry ; Drug Delivery Systems ; General pharmacology ; Hydrophobic and Hydrophilic Interactions ; Ibuprofen ; Ibuprofen - administration & dosage ; Ibuprofen - chemistry ; Ibuprofen - pharmacokinetics ; In vitro ; In vivo ; Injections, Subcutaneous ; Lactic Acid - chemistry ; Male ; Medical sciences ; Microspheres ; Nanoparticles ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Poly(lactic-co-glycolic) acid ; Poly(ε-caprolactone) ; Polyesters - chemistry ; Polyglycolic Acid - chemistry ; Polymers - chemistry ; Rats ; Rats, Wistar</subject><ispartof>European journal of pharmaceutics and biopharmaceutics, 2009-11, Vol.73 (3), p.337-344</ispartof><rights>2009 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-4bd6fe5e32673adc0eb4e6f511c59b735f23429644c6db78e2c374da57e4f2743</citedby><cites>FETCH-LOGICAL-c385t-4bd6fe5e32673adc0eb4e6f511c59b735f23429644c6db78e2c374da57e4f2743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0939641109002380$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22154929$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19651210$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sheikh Hassan, A.</creatorcontrib><creatorcontrib>Sapin, A.</creatorcontrib><creatorcontrib>Lamprecht, A.</creatorcontrib><creatorcontrib>Emond, E.</creatorcontrib><creatorcontrib>El Ghazouani, F.</creatorcontrib><creatorcontrib>Maincent, P.</creatorcontrib><title>Composite microparticles with in vivo reduction of the burst release effect</title><title>European journal of pharmaceutics and biopharmaceutics</title><addtitle>Eur J Pharm Biopharm</addtitle><description>The aim of this study was to develop microparticles containing nanoparticles (composite microparticles) for prolonged drug delivery with reduced burst effect
in vitro and
in vivo. Such composite microparticles were prepared with hydrophobic and biodegradable polymers [poly(ε-caprolactone), poly(lactic-co-glycolic) acid]. Ibuprofen was chosen as the model drug, and microparticles were prepared by the extraction technique with ethyl acetate as the solvent. Nanoparticles and microparticles and an ibuprofen solution (Pedea
®) were administered subcutaneously at the dose of 1
mg of ibuprofen per kg to overnight-fasted rats (male Wistar). Composite microparticles showed prolonged ibuprofen release and less burst effect when compared to simple microparticles (without nanoparticles inside) or nanoparticles both
in vitro (PBS buffer) and
in vivo. Moreover, ibuprofen was still detected in the plasma after 96
h with composite microparticles. Consequently, it has been demonstrated that composite microparticles were able to reduce burst release and prolong the release of ibuprofen for a long period of time.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemistry</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Burst effect</subject><subject>Chemistry, Pharmaceutical</subject><subject>Composite microparticles</subject><subject>Delayed-Action Preparations</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Delivery Systems</subject><subject>General pharmacology</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Ibuprofen</subject><subject>Ibuprofen - administration & dosage</subject><subject>Ibuprofen - chemistry</subject><subject>Ibuprofen - pharmacokinetics</subject><subject>In vitro</subject><subject>In vivo</subject><subject>Injections, Subcutaneous</subject><subject>Lactic Acid - chemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microspheres</subject><subject>Nanoparticles</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Poly(lactic-co-glycolic) acid</subject><subject>Poly(ε-caprolactone)</subject><subject>Polyesters - chemistry</subject><subject>Polyglycolic Acid - chemistry</subject><subject>Polymers - chemistry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0939-6411</issn><issn>1873-3441</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpaDbb_oEeii6hJzv6tNbQS1nSJCSQS3oWsjwiWmzLleQN-ffRskty6-mF4ZmXmQeh75TUlNDmalfDbu5qRkhbE1WX-IRWdKN4xYWgn9GKtLytGkHpObpIaUcIEUpuvqBz2jaSMkpW6H4bxjkknwGP3sYwm5i9HSDhF5-fsZ_w3u8DjtAvNvsw4eBwfgbcLTHlMh7AJMDgHNj8FZ05MyT4dso1-vvn-ml7Wz083txtfz9Ulm9krkTXNw4kcNYobnpLoBPQOEmplW2nuHSMC9Y2Qtim79QGmOVK9EYqEI4pwdfo57F3juHfAinr0ScLw2AmCEvSigvKBCnta8SOZPkspQhOz9GPJr5qSvTBod7pg0N9cKiJ0iXK0o9T_dKN0H-snKQV4PIEmGTN4KKZrE_vHGNUipYdin4dOSgy9h6iTtbDZKH3sejSffD_u-MNJlOPug</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Sheikh Hassan, A.</creator><creator>Sapin, A.</creator><creator>Lamprecht, A.</creator><creator>Emond, E.</creator><creator>El Ghazouani, F.</creator><creator>Maincent, P.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Composite microparticles with in vivo reduction of the burst release effect</title><author>Sheikh Hassan, A. ; Sapin, A. ; Lamprecht, A. ; Emond, E. ; El Ghazouani, F. ; Maincent, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-4bd6fe5e32673adc0eb4e6f511c59b735f23429644c6db78e2c374da57e4f2743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemistry</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Burst effect</topic><topic>Chemistry, Pharmaceutical</topic><topic>Composite microparticles</topic><topic>Delayed-Action Preparations</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Delivery Systems</topic><topic>General pharmacology</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>Ibuprofen</topic><topic>Ibuprofen - administration & dosage</topic><topic>Ibuprofen - chemistry</topic><topic>Ibuprofen - pharmacokinetics</topic><topic>In vitro</topic><topic>In vivo</topic><topic>Injections, Subcutaneous</topic><topic>Lactic Acid - chemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microspheres</topic><topic>Nanoparticles</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Poly(lactic-co-glycolic) acid</topic><topic>Poly(ε-caprolactone)</topic><topic>Polyesters - chemistry</topic><topic>Polyglycolic Acid - chemistry</topic><topic>Polymers - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sheikh Hassan, A.</creatorcontrib><creatorcontrib>Sapin, A.</creatorcontrib><creatorcontrib>Lamprecht, A.</creatorcontrib><creatorcontrib>Emond, E.</creatorcontrib><creatorcontrib>El Ghazouani, F.</creatorcontrib><creatorcontrib>Maincent, P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sheikh Hassan, A.</au><au>Sapin, A.</au><au>Lamprecht, A.</au><au>Emond, E.</au><au>El Ghazouani, F.</au><au>Maincent, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Composite microparticles with in vivo reduction of the burst release effect</atitle><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle><addtitle>Eur J Pharm Biopharm</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>73</volume><issue>3</issue><spage>337</spage><epage>344</epage><pages>337-344</pages><issn>0939-6411</issn><eissn>1873-3441</eissn><abstract>The aim of this study was to develop microparticles containing nanoparticles (composite microparticles) for prolonged drug delivery with reduced burst effect
in vitro and
in vivo. Such composite microparticles were prepared with hydrophobic and biodegradable polymers [poly(ε-caprolactone), poly(lactic-co-glycolic) acid]. Ibuprofen was chosen as the model drug, and microparticles were prepared by the extraction technique with ethyl acetate as the solvent. Nanoparticles and microparticles and an ibuprofen solution (Pedea
®) were administered subcutaneously at the dose of 1
mg of ibuprofen per kg to overnight-fasted rats (male Wistar). Composite microparticles showed prolonged ibuprofen release and less burst effect when compared to simple microparticles (without nanoparticles inside) or nanoparticles both
in vitro (PBS buffer) and
in vivo. Moreover, ibuprofen was still detected in the plasma after 96
h with composite microparticles. Consequently, it has been demonstrated that composite microparticles were able to reduce burst release and prolong the release of ibuprofen for a long period of time.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>19651210</pmid><doi>10.1016/j.ejpb.2009.07.009</doi><tpages>8</tpages></addata></record> |
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| ispartof | European journal of pharmaceutics and biopharmaceutics, 2009-11, Vol.73 (3), p.337-344 |
| issn | 0939-6411 1873-3441 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Biological and medical sciences Burst effect Chemistry, Pharmaceutical Composite microparticles Delayed-Action Preparations Drug Carriers - chemistry Drug Delivery Systems General pharmacology Hydrophobic and Hydrophilic Interactions Ibuprofen Ibuprofen - administration & dosage Ibuprofen - chemistry Ibuprofen - pharmacokinetics In vitro In vivo Injections, Subcutaneous Lactic Acid - chemistry Male Medical sciences Microspheres Nanoparticles Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poly(lactic-co-glycolic) acid Poly(ε-caprolactone) Polyesters - chemistry Polyglycolic Acid - chemistry Polymers - chemistry Rats Rats, Wistar |
| title | Composite microparticles with in vivo reduction of the burst release effect |
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