Dry-powder pulmonary insufflation in the mouse for application to vaccine or drug studies
Summary Pulmonary delivery of substances in small animal models is often useful for experimental testing of various vaccine and drug candidates. One of the most challenging elements to such protocols is the efficient disposition of test materials in the lungs of mice. Herein we detail a means to del...
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| Veröffentlicht in: | Tuberculosis (Edinburgh, Scotland) Scotland), 2009-09, Vol.89 (5), p.371-377 |
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| container_title | Tuberculosis (Edinburgh, Scotland) |
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| creator | Morello, Melissa Krone, Cassandra L Dickerson, Shelley Howerth, Elizabeth Germishuizen, Willem Andreas Wong, Yun-Ling Edwards, David Bloom, Barry R Hondalus, Mary K |
| description | Summary Pulmonary delivery of substances in small animal models is often useful for experimental testing of various vaccine and drug candidates. One of the most challenging elements to such protocols is the efficient disposition of test materials in the lungs of mice. Herein we detail a means to deliver dry powders of an inhalant live-attenuated Mycobacterium bovis Bacille Calmette-Guerin (BCG) vaccine against Mycobacterium tuberculosis to the lungs of mice. The direct delivery methodology is quick, safe, and allows for repeated pulmonary insufflation of substances if boosting is desired. This model system could be easily adapted for use with other dry-powder vaccine and drug candidates. |
| doi_str_mv | 10.1016/j.tube.2009.07.001 |
| format | Article |
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One of the most challenging elements to such protocols is the efficient disposition of test materials in the lungs of mice. Herein we detail a means to deliver dry powders of an inhalant live-attenuated Mycobacterium bovis Bacille Calmette-Guerin (BCG) vaccine against Mycobacterium tuberculosis to the lungs of mice. The direct delivery methodology is quick, safe, and allows for repeated pulmonary insufflation of substances if boosting is desired. 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This model system could be easily adapted for use with other dry-powder vaccine and drug candidates.</description><subject>Administration, Oral</subject><subject>Aerosols</subject><subject>Animals</subject><subject>BCG</subject><subject>BCG Vaccine - administration & dosage</subject><subject>BCG Vaccine - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Infectious Disease</subject><subject>Inhalant vaccine</subject><subject>Insufflation</subject><subject>Lung - drug effects</subject><subject>Lung - immunology</subject><subject>Lung - pathology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mycobacterium bovis - immunology</subject><subject>Mycobacterium bovis - pathogenicity</subject><subject>Powders</subject><subject>Pulmonary intubation</subject><subject>Pulmonary/Respiratory</subject><issn>1472-9792</issn><issn>1873-281X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV-L1TAQxYMo7rr6BXyQvPnUOkl6mwZEkF3_LCz4sCvoU0jTiebaNjVpVu63N-VeEHzYp0yYc4Y5vyHkJYOaAWvf7Os191hzAFWDrAHYI3LOOikq3rFvj0vdSF4pqfgZeZbSvgha6OApOWOqFbxT8px8v4qHagl_Box0yeMUZhMP1M8pOzea1Ye5fOj6E-kUckLqQqRmWUZvj8010HtjrZ-Rls4Q8w-a1jx4TM_JE2fGhC9O7wX5-vHD3eXn6ubLp-vL9zeVbWS7Vr0VTElsZctYx8HsHO6kNLI3hrewG2zfmN5JZ4U0O6VEg0aakli4IhGOiQvy-jh3ieF3xrTqySeL42hmLCtrKRrGG2i6ouRHpY0hpYhOL9FPJa9moDeieq83onojqkHqAqyYXp3G537C4Z_lhLAI3h4FWELee4w6WY-zxcFHtKsegn94_rv_7Hb0c8E7_sIDpn3IcS74NNOJa9C32023k4ICgFKKv6I3nbw</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Morello, Melissa</creator><creator>Krone, Cassandra L</creator><creator>Dickerson, Shelley</creator><creator>Howerth, Elizabeth</creator><creator>Germishuizen, Willem Andreas</creator><creator>Wong, Yun-Ling</creator><creator>Edwards, David</creator><creator>Bloom, Barry R</creator><creator>Hondalus, Mary K</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090901</creationdate><title>Dry-powder pulmonary insufflation in the mouse for application to vaccine or drug studies</title><author>Morello, Melissa ; Krone, Cassandra L ; Dickerson, Shelley ; Howerth, Elizabeth ; Germishuizen, Willem Andreas ; Wong, Yun-Ling ; Edwards, David ; Bloom, Barry R ; Hondalus, Mary K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-bc3197e67611820a5fe577a7baa2605dcb4abf7fc37a59934ea7a0093f7ba3f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Administration, Oral</topic><topic>Aerosols</topic><topic>Animals</topic><topic>BCG</topic><topic>BCG Vaccine - administration & dosage</topic><topic>BCG Vaccine - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Infectious Disease</topic><topic>Inhalant vaccine</topic><topic>Insufflation</topic><topic>Lung - drug effects</topic><topic>Lung - immunology</topic><topic>Lung - pathology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mycobacterium bovis - immunology</topic><topic>Mycobacterium bovis - pathogenicity</topic><topic>Powders</topic><topic>Pulmonary intubation</topic><topic>Pulmonary/Respiratory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morello, Melissa</creatorcontrib><creatorcontrib>Krone, Cassandra L</creatorcontrib><creatorcontrib>Dickerson, Shelley</creatorcontrib><creatorcontrib>Howerth, Elizabeth</creatorcontrib><creatorcontrib>Germishuizen, Willem Andreas</creatorcontrib><creatorcontrib>Wong, Yun-Ling</creatorcontrib><creatorcontrib>Edwards, David</creatorcontrib><creatorcontrib>Bloom, Barry R</creatorcontrib><creatorcontrib>Hondalus, Mary K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Tuberculosis (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morello, Melissa</au><au>Krone, Cassandra L</au><au>Dickerson, Shelley</au><au>Howerth, Elizabeth</au><au>Germishuizen, Willem Andreas</au><au>Wong, Yun-Ling</au><au>Edwards, David</au><au>Bloom, Barry R</au><au>Hondalus, Mary K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dry-powder pulmonary insufflation in the mouse for application to vaccine or drug studies</atitle><jtitle>Tuberculosis (Edinburgh, Scotland)</jtitle><addtitle>Tuberculosis (Edinb)</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>89</volume><issue>5</issue><spage>371</spage><epage>377</epage><pages>371-377</pages><issn>1472-9792</issn><eissn>1873-281X</eissn><abstract>Summary Pulmonary delivery of substances in small animal models is often useful for experimental testing of various vaccine and drug candidates. One of the most challenging elements to such protocols is the efficient disposition of test materials in the lungs of mice. Herein we detail a means to deliver dry powders of an inhalant live-attenuated Mycobacterium bovis Bacille Calmette-Guerin (BCG) vaccine against Mycobacterium tuberculosis to the lungs of mice. The direct delivery methodology is quick, safe, and allows for repeated pulmonary insufflation of substances if boosting is desired. This model system could be easily adapted for use with other dry-powder vaccine and drug candidates.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>19632897</pmid><doi>10.1016/j.tube.2009.07.001</doi><tpages>7</tpages></addata></record> |
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| ispartof | Tuberculosis (Edinburgh, Scotland), 2009-09, Vol.89 (5), p.371-377 |
| issn | 1472-9792 1873-281X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Oral Aerosols Animals BCG BCG Vaccine - administration & dosage BCG Vaccine - pharmacology Disease Models, Animal Female Infectious Disease Inhalant vaccine Insufflation Lung - drug effects Lung - immunology Lung - pathology Mice Mice, Inbred BALB C Mycobacterium bovis - immunology Mycobacterium bovis - pathogenicity Powders Pulmonary intubation Pulmonary/Respiratory |
| title | Dry-powder pulmonary insufflation in the mouse for application to vaccine or drug studies |
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