Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist

The widely reported effects of oxytocin (OT) on CNS function has generated considerable interest in the therapeutic potential for targeting this system for a variety of human psychiatric diseases, including anxiety disorders, autism, schizophrenia, and depression. The utility of synthetic OT, as bot...

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Veröffentlicht in:	Neuropharmacology 2010, Vol.58 (1), p.69-77
Hauptverfasser:	Ring, Robert H., Schechter, Lee E., Leonard, Sarah K., Dwyer, Jason M., Platt, Brian J., Graf, Radka, Grauer, Steven, Pulicicchio, Claudine, Resnick, Lynn, Rahman, Zia, Sukoff Rizzo, Stacey J., Luo, Bin, Beyer, Chad E., Logue, Sheree F., Marquis, Karen L., Hughes, Zoë A., Rosenzweig-Lipson, Sharon
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation - adverse effects Animals Anti-Anxiety Agents - pharmacology Anxiety Autistic spectrum disorders Avoidance Learning - drug effects Behavior, Animal - drug effects Benzodiazepines - pharmacology Benzodiazepines - therapeutic use CHO Cells Cricetinae Cricetulus Depression Fever - drug therapy Fever - etiology Hindlimb Suspension - methods Humans Male Maze Learning - drug effects Mice Mice, Inbred C57BL Neural Inhibition - drug effects Oxytocin Oxytocin - agonists Oxytocin - pharmacology Protein Binding - drug effects Pyrazoles - pharmacology Pyrazoles - therapeutic use Rats Rats, Sprague-Dawley Receptors, Oxytocin - agonists Reflex, Startle - drug effects Reflex, Startle - physiology Schizophrenia Stress, Psychological - complications Vasopressin
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