A plausible role of salivary copper in antimicrobial activity of histatin-5 —Metal binding and oxidative activity of its copper complex

Histatin-5 (Hn5) is an antimicrobial salivary peptide of 24 amino acids. Two specific metal-binding sites were revealed with electronic, NMR, and EPR spectroscopy. The complex Cu 2 II –Hn5 effectively oxidizes catechol, exhibiting enzyme-like kinetics ( k cat = 0.011 and 0.060 s −1 and k cat/ K m =...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-12, Vol.19 (23), p.6709-6712
Hauptverfasser:	Tay, William M., Hanafy, Ahmed I., Angerhofer, Alexander, Ming, Li-June
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotic Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Bacteria - drug effects Binding Sites Biological and medical sciences Catechol Cobalt Copper Copper - chemistry Drug Design EPR Fundamental and applied biological sciences. Psychology Fungi - drug effects General aspects Histatin Histatins - chemistry Humans Medical sciences Metallopeptide Microbial Sensitivity Tests Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus NMR Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Oxidation Oxidation-Reduction Pharmacology. Drug treatments Saliva - chemistry Structure-Activity Relationship Vertebrates: digestive system
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