Late gadolinium enhancement-cardiovascular magnetic resonance identifies coronary artery disease as the aetiology of left ventricular dysfunction in acute new-onset congestive heart failure
Aims We evaluated the ability of late gadolinium enhancement (LGE) using cardiovascular magnetic resonance (CMR) to identify acute new-onset heart failure (HF) with left ventricular systolic dysfunction (LVSD), whether or not in relation to underlying coronary artery disease (CAD), in patients with...
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| Veröffentlicht in: | European journal of echocardiography 2009-12, Vol.10 (8), p.968-974 |
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| creator | Valle-Muñoz, Alfonso Estornell-Erill, Jordi Soriano-Navarro, Carlos J. Nadal-Barange, Mercedes Martinez-Alzamora, Nieves Pomar-Domingo, Francisco Corbí-Pascual, Miguel Payá-Serrano, Rafael Ridocci-Soriano, Francisco |
| description | Aims
We evaluated the ability of late gadolinium enhancement (LGE) using cardiovascular magnetic resonance (CMR) to identify acute new-onset heart failure (HF) with left ventricular systolic dysfunction (LVSD), whether or not in relation to underlying coronary artery disease (CAD), in patients with no clinical evidence of associated ischaemic cardiomyopathy.
Methods and results
Hundred consecutive patients admitted with acute new-onset decompensated HF and EF |
| doi_str_mv | 10.1093/ejechocard/jep115 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734123244</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ejechocard/jep115</oup_id><sourcerecordid>734123244</sourcerecordid><originalsourceid>FETCH-LOGICAL-c380t-59055c6117d8abd3bc0066171723ee3db643d322e813560f16610a50906936823</originalsourceid><addsrcrecordid>eNqNkcuO0zAUhi0EYoaBB2CDvGNDZnyJnWSJRlxGqsQG1pFrn7SuErv4UtSH4904VSrNltWx7O__dOSfkPec3XM2yAc4gN1Ha5J7OMCRc_WC3HIlRSM4b19ezkLhWXc35E3OB8YQke1rcsOHTqlW97fk78YUoDvj4uyDrwuFsDfBwgKhNBezjyeTbZ1NoovZBSje0gQ5hgtFvUPOTx4ytTHhZTpTkwrgcD6DyUBNpmWPA5NxjrszjROdYSr0hNHkV7U756kGi0igPlBjK24V4E8TQ4aC7rCDXPwJ6B7QTyfj55rgLXk1mTnDu-u8I7--fvn5-L3Z_Pj29Ph501jZs9KogSllNeed683Wya1lTGve8U5IAOm2upVOCgE9l0qzieMjM4oNTA9S90LekY-r95ji74qbjIvPFubZBIg1j51suZCibZHkK2lTzDnBNB6TX_BbRs7GS2njc2njWhpmPlztdbuAe05cW0Lg0wrEevwP3z-oaqrc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>734123244</pqid></control><display><type>article</type><title>Late gadolinium enhancement-cardiovascular magnetic resonance identifies coronary artery disease as the aetiology of left ventricular dysfunction in acute new-onset congestive heart failure</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Valle-Muñoz, Alfonso ; Estornell-Erill, Jordi ; Soriano-Navarro, Carlos J. ; Nadal-Barange, Mercedes ; Martinez-Alzamora, Nieves ; Pomar-Domingo, Francisco ; Corbí-Pascual, Miguel ; Payá-Serrano, Rafael ; Ridocci-Soriano, Francisco</creator><creatorcontrib>Valle-Muñoz, Alfonso ; Estornell-Erill, Jordi ; Soriano-Navarro, Carlos J. ; Nadal-Barange, Mercedes ; Martinez-Alzamora, Nieves ; Pomar-Domingo, Francisco ; Corbí-Pascual, Miguel ; Payá-Serrano, Rafael ; Ridocci-Soriano, Francisco</creatorcontrib><description>Aims
We evaluated the ability of late gadolinium enhancement (LGE) using cardiovascular magnetic resonance (CMR) to identify acute new-onset heart failure (HF) with left ventricular systolic dysfunction (LVSD), whether or not in relation to underlying coronary artery disease (CAD), in patients with no clinical evidence of associated ischaemic cardiomyopathy.
Methods and results
Hundred consecutive patients admitted with acute new-onset decompensated HF and EF <40%, with no clinical or electrocardiographic data suggestive of CAD. The patients were classified according to the presence or absence of significant CAD (stenosis ≥70% in at least one major vessel). Twenty-one patients (21%) had significant CAD. Seventy-nine (79%) had no lesions. Eighteen of the 21 patients (85%) with CAD had subendocardial/transmural LGE. In the diagnosis of CAD, LGE has a sensitivity of 85.7% (95% CI, 80-91) and specificity of 92.4% (95% CI, 87-96), respectively, with a negative predictive value of 96% (95% CI, 90-99). It has an area under the receiver operating characteristic curve of 0.906 (95% CI, 0.814-0.998).
Conclusion
In patients with new-onset HF and LVSD for whom there are no clinical and exploratory data suggestive of ischaemic heart disease, CMR with LGE is an excellent means of ruling out significant CAD and is a valid alternative to angiography.</description><identifier>ISSN: 1525-2167</identifier><identifier>EISSN: 1532-2114</identifier><identifier>DOI: 10.1093/ejechocard/jep115</identifier><identifier>PMID: 19755468</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Area Under Curve ; Chi-Square Distribution ; Contrast Media ; Coronary Angiography ; Coronary Artery Disease - complications ; Coronary Artery Disease - physiopathology ; Electrocardiography ; Female ; Gadolinium DTPA ; Heart Failure - etiology ; Heart Failure - physiopathology ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Predictive Value of Tests ; Sensitivity and Specificity ; Statistics, Nonparametric ; Ventricular Dysfunction, Left - etiology ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>European journal of echocardiography, 2009-12, Vol.10 (8), p.968-974</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org 2009</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-59055c6117d8abd3bc0066171723ee3db643d322e813560f16610a50906936823</citedby><cites>FETCH-LOGICAL-c380t-59055c6117d8abd3bc0066171723ee3db643d322e813560f16610a50906936823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1581,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19755468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Valle-Muñoz, Alfonso</creatorcontrib><creatorcontrib>Estornell-Erill, Jordi</creatorcontrib><creatorcontrib>Soriano-Navarro, Carlos J.</creatorcontrib><creatorcontrib>Nadal-Barange, Mercedes</creatorcontrib><creatorcontrib>Martinez-Alzamora, Nieves</creatorcontrib><creatorcontrib>Pomar-Domingo, Francisco</creatorcontrib><creatorcontrib>Corbí-Pascual, Miguel</creatorcontrib><creatorcontrib>Payá-Serrano, Rafael</creatorcontrib><creatorcontrib>Ridocci-Soriano, Francisco</creatorcontrib><title>Late gadolinium enhancement-cardiovascular magnetic resonance identifies coronary artery disease as the aetiology of left ventricular dysfunction in acute new-onset congestive heart failure</title><title>European journal of echocardiography</title><addtitle>Eur J Echocardiogr</addtitle><description>Aims
We evaluated the ability of late gadolinium enhancement (LGE) using cardiovascular magnetic resonance (CMR) to identify acute new-onset heart failure (HF) with left ventricular systolic dysfunction (LVSD), whether or not in relation to underlying coronary artery disease (CAD), in patients with no clinical evidence of associated ischaemic cardiomyopathy.
Methods and results
Hundred consecutive patients admitted with acute new-onset decompensated HF and EF <40%, with no clinical or electrocardiographic data suggestive of CAD. The patients were classified according to the presence or absence of significant CAD (stenosis ≥70% in at least one major vessel). Twenty-one patients (21%) had significant CAD. Seventy-nine (79%) had no lesions. Eighteen of the 21 patients (85%) with CAD had subendocardial/transmural LGE. In the diagnosis of CAD, LGE has a sensitivity of 85.7% (95% CI, 80-91) and specificity of 92.4% (95% CI, 87-96), respectively, with a negative predictive value of 96% (95% CI, 90-99). It has an area under the receiver operating characteristic curve of 0.906 (95% CI, 0.814-0.998).
Conclusion
In patients with new-onset HF and LVSD for whom there are no clinical and exploratory data suggestive of ischaemic heart disease, CMR with LGE is an excellent means of ruling out significant CAD and is a valid alternative to angiography.</description><subject>Area Under Curve</subject><subject>Chi-Square Distribution</subject><subject>Contrast Media</subject><subject>Coronary Angiography</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Gadolinium DTPA</subject><subject>Heart Failure - etiology</subject><subject>Heart Failure - physiopathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Sensitivity and Specificity</subject><subject>Statistics, Nonparametric</subject><subject>Ventricular Dysfunction, Left - etiology</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>1525-2167</issn><issn>1532-2114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcuO0zAUhi0EYoaBB2CDvGNDZnyJnWSJRlxGqsQG1pFrn7SuErv4UtSH4904VSrNltWx7O__dOSfkPec3XM2yAc4gN1Ha5J7OMCRc_WC3HIlRSM4b19ezkLhWXc35E3OB8YQke1rcsOHTqlW97fk78YUoDvj4uyDrwuFsDfBwgKhNBezjyeTbZ1NoovZBSje0gQ5hgtFvUPOTx4ytTHhZTpTkwrgcD6DyUBNpmWPA5NxjrszjROdYSr0hNHkV7U756kGi0igPlBjK24V4E8TQ4aC7rCDXPwJ6B7QTyfj55rgLXk1mTnDu-u8I7--fvn5-L3Z_Pj29Ph501jZs9KogSllNeed683Wya1lTGve8U5IAOm2upVOCgE9l0qzieMjM4oNTA9S90LekY-r95ji74qbjIvPFubZBIg1j51suZCibZHkK2lTzDnBNB6TX_BbRs7GS2njc2njWhpmPlztdbuAe05cW0Lg0wrEevwP3z-oaqrc</recordid><startdate>200912</startdate><enddate>200912</enddate><creator>Valle-Muñoz, Alfonso</creator><creator>Estornell-Erill, Jordi</creator><creator>Soriano-Navarro, Carlos J.</creator><creator>Nadal-Barange, Mercedes</creator><creator>Martinez-Alzamora, Nieves</creator><creator>Pomar-Domingo, Francisco</creator><creator>Corbí-Pascual, Miguel</creator><creator>Payá-Serrano, Rafael</creator><creator>Ridocci-Soriano, Francisco</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200912</creationdate><title>Late gadolinium enhancement-cardiovascular magnetic resonance identifies coronary artery disease as the aetiology of left ventricular dysfunction in acute new-onset congestive heart failure</title><author>Valle-Muñoz, Alfonso ; Estornell-Erill, Jordi ; Soriano-Navarro, Carlos J. ; Nadal-Barange, Mercedes ; Martinez-Alzamora, Nieves ; Pomar-Domingo, Francisco ; Corbí-Pascual, Miguel ; Payá-Serrano, Rafael ; Ridocci-Soriano, Francisco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-59055c6117d8abd3bc0066171723ee3db643d322e813560f16610a50906936823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Area Under Curve</topic><topic>Chi-Square Distribution</topic><topic>Contrast Media</topic><topic>Coronary Angiography</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Gadolinium DTPA</topic><topic>Heart Failure - etiology</topic><topic>Heart Failure - physiopathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Sensitivity and Specificity</topic><topic>Statistics, Nonparametric</topic><topic>Ventricular Dysfunction, Left - etiology</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Valle-Muñoz, Alfonso</creatorcontrib><creatorcontrib>Estornell-Erill, Jordi</creatorcontrib><creatorcontrib>Soriano-Navarro, Carlos J.</creatorcontrib><creatorcontrib>Nadal-Barange, Mercedes</creatorcontrib><creatorcontrib>Martinez-Alzamora, Nieves</creatorcontrib><creatorcontrib>Pomar-Domingo, Francisco</creatorcontrib><creatorcontrib>Corbí-Pascual, Miguel</creatorcontrib><creatorcontrib>Payá-Serrano, Rafael</creatorcontrib><creatorcontrib>Ridocci-Soriano, Francisco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of echocardiography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Valle-Muñoz, Alfonso</au><au>Estornell-Erill, Jordi</au><au>Soriano-Navarro, Carlos J.</au><au>Nadal-Barange, Mercedes</au><au>Martinez-Alzamora, Nieves</au><au>Pomar-Domingo, Francisco</au><au>Corbí-Pascual, Miguel</au><au>Payá-Serrano, Rafael</au><au>Ridocci-Soriano, Francisco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Late gadolinium enhancement-cardiovascular magnetic resonance identifies coronary artery disease as the aetiology of left ventricular dysfunction in acute new-onset congestive heart failure</atitle><jtitle>European journal of echocardiography</jtitle><addtitle>Eur J Echocardiogr</addtitle><date>2009-12</date><risdate>2009</risdate><volume>10</volume><issue>8</issue><spage>968</spage><epage>974</epage><pages>968-974</pages><issn>1525-2167</issn><eissn>1532-2114</eissn><abstract>Aims
We evaluated the ability of late gadolinium enhancement (LGE) using cardiovascular magnetic resonance (CMR) to identify acute new-onset heart failure (HF) with left ventricular systolic dysfunction (LVSD), whether or not in relation to underlying coronary artery disease (CAD), in patients with no clinical evidence of associated ischaemic cardiomyopathy.
Methods and results
Hundred consecutive patients admitted with acute new-onset decompensated HF and EF <40%, with no clinical or electrocardiographic data suggestive of CAD. The patients were classified according to the presence or absence of significant CAD (stenosis ≥70% in at least one major vessel). Twenty-one patients (21%) had significant CAD. Seventy-nine (79%) had no lesions. Eighteen of the 21 patients (85%) with CAD had subendocardial/transmural LGE. In the diagnosis of CAD, LGE has a sensitivity of 85.7% (95% CI, 80-91) and specificity of 92.4% (95% CI, 87-96), respectively, with a negative predictive value of 96% (95% CI, 90-99). It has an area under the receiver operating characteristic curve of 0.906 (95% CI, 0.814-0.998).
Conclusion
In patients with new-onset HF and LVSD for whom there are no clinical and exploratory data suggestive of ischaemic heart disease, CMR with LGE is an excellent means of ruling out significant CAD and is a valid alternative to angiography.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>19755468</pmid><doi>10.1093/ejechocard/jep115</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Area Under Curve Chi-Square Distribution Contrast Media Coronary Angiography Coronary Artery Disease - complications Coronary Artery Disease - physiopathology Electrocardiography Female Gadolinium DTPA Heart Failure - etiology Heart Failure - physiopathology Humans Magnetic Resonance Imaging - methods Male Middle Aged Predictive Value of Tests Sensitivity and Specificity Statistics, Nonparametric Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - physiopathology |
| title | Late gadolinium enhancement-cardiovascular magnetic resonance identifies coronary artery disease as the aetiology of left ventricular dysfunction in acute new-onset congestive heart failure |
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