Distribution of estrogen receptor β mRNA‐containing cells in ovariectomized and estrogen‐treated female rat brain
Estrogen receptor (ER)‐β is a member of the nuclear receptor superfamily and mediates various estrogenic actions. Changes in ER‐α mRNA expression induced by estrogen have been well documented, whereas those with regard to ER‐β have only been reported for a part of the hypothalamus. In the present st...
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| Veröffentlicht in: | Anatomical Science International 2003-06, Vol.78 (2), p.85-97 |
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| description | Estrogen receptor (ER)‐β is a member of the nuclear receptor superfamily and mediates various estrogenic actions. Changes in ER‐α mRNA expression induced by estrogen have been well documented, whereas those with regard to ER‐β have only been reported for a part of the hypothalamus. In the present study, we examined the effect of estrogen on ER‐β mRNA expression in the female rat brain. Detection of ER‐β mRNA using the in situ hybridization method with a digoxigenin‐labeled RNA probe was performed in two groups of female rats: ovariectomized (OVX) and estrogen (E2)‐treated. A wide distribution of ER‐β mRNA‐containing cells was demonstrated in both groups. In the E2‐treated group compared with the OVX group, the number of ER‐β mRNA‐containing cells was significantly reduced in the external plexiform layer of the olfactory bulb, entorhinal cortex, intermediate part of the lateral septal nucleus, nucleus of the horizontal limb of the diagonal band, amygdala (lateral, medial and basolateral part), thalamus (anteroventral, laterodorsal and lateral posterior part), medial geniculate nucleus, suprachiasmatic nucleus and Purkinje cells in the cerebellum. These results reveal that ER‐β mRNA‐containing cells were decreased by estrogen in several brain regions in the female rat brain, suggesting that ER‐β mRNA is downregulated by the physiological level of estrogen in a region‐specific manner. |
| doi_str_mv | 10.1046/j.0022-7722.2003.00042.x |
| format | Article |
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Changes in ER‐α mRNA expression induced by estrogen have been well documented, whereas those with regard to ER‐β have only been reported for a part of the hypothalamus. In the present study, we examined the effect of estrogen on ER‐β mRNA expression in the female rat brain. Detection of ER‐β mRNA using the in situ hybridization method with a digoxigenin‐labeled RNA probe was performed in two groups of female rats: ovariectomized (OVX) and estrogen (E2)‐treated. A wide distribution of ER‐β mRNA‐containing cells was demonstrated in both groups. In the E2‐treated group compared with the OVX group, the number of ER‐β mRNA‐containing cells was significantly reduced in the external plexiform layer of the olfactory bulb, entorhinal cortex, intermediate part of the lateral septal nucleus, nucleus of the horizontal limb of the diagonal band, amygdala (lateral, medial and basolateral part), thalamus (anteroventral, laterodorsal and lateral posterior part), medial geniculate nucleus, suprachiasmatic nucleus and Purkinje cells in the cerebellum. 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Changes in ER‐α mRNA expression induced by estrogen have been well documented, whereas those with regard to ER‐β have only been reported for a part of the hypothalamus. In the present study, we examined the effect of estrogen on ER‐β mRNA expression in the female rat brain. Detection of ER‐β mRNA using the in situ hybridization method with a digoxigenin‐labeled RNA probe was performed in two groups of female rats: ovariectomized (OVX) and estrogen (E2)‐treated. A wide distribution of ER‐β mRNA‐containing cells was demonstrated in both groups. In the E2‐treated group compared with the OVX group, the number of ER‐β mRNA‐containing cells was significantly reduced in the external plexiform layer of the olfactory bulb, entorhinal cortex, intermediate part of the lateral septal nucleus, nucleus of the horizontal limb of the diagonal band, amygdala (lateral, medial and basolateral part), thalamus (anteroventral, laterodorsal and lateral posterior part), medial geniculate nucleus, suprachiasmatic nucleus and Purkinje cells in the cerebellum. These results reveal that ER‐β mRNA‐containing cells were decreased by estrogen in several brain regions in the female rat brain, suggesting that ER‐β mRNA is downregulated by the physiological level of estrogen in a region‐specific manner.</description><subject>Amygdala</subject><subject>Animals</subject><subject>Brain - cytology</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain Mapping</subject><subject>Cerebellum</subject><subject>Cortex (entorhinal)</subject><subject>Cortex (olfactory)</subject><subject>Digoxigenin</subject><subject>Down-Regulation - drug effects</subject><subject>Down-Regulation - genetics</subject><subject>estradiol</subject><subject>estrogen receptor</subject><subject>Estrogen Receptor beta</subject><subject>Estrogen receptors</subject><subject>estrogen receptor‐β</subject><subject>Estrogens</subject><subject>Estrogens - metabolism</subject><subject>Estrogens - pharmacology</subject><subject>Estrous Cycle - genetics</subject><subject>Female</subject><subject>Gene expression</subject><subject>Hybridization</subject><subject>Hypothalamus</subject><subject>in situ hybridization</subject><subject>Medial geniculate body</subject><subject>Neurons - cytology</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Olfactory bulb</subject><subject>Ovariectomy</subject><subject>Purkinje cells</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Estrogen - genetics</subject><subject>RNA probes</subject><subject>RNA, Messenger - drug effects</subject><subject>RNA, Messenger - metabolism</subject><subject>Sexual Behavior - drug effects</subject><subject>Sexual Behavior - physiology</subject><subject>steroid</subject><subject>Suprachiasmatic nucleus</subject><subject>Thalamus</subject><subject>Xenoestrogens</subject><issn>1447-6959</issn><issn>0022-7722</issn><issn>1447-073X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkdtqFTEUhoNYbK2-ggQE72Y3h5lJcuHFpvVQKBU8gHchhzUlm5nJNpmprVc-gs_ig_gQPkkz3RsFr7zKWuH___XDhxCmZEVJ3Z5sVoQwVgnB2IoRwstKara6eYCOaF2Ligj--eF-blWjDtHjnDeEUNVQ_ggdUiaZrBk9QtdnIU8p2HkKccSxw1DWeAUjTuBgO8WEf_3Ew_vL9e_vP1wcJxPGMF5hB32fcSiWa5MCuCkO4Rt4bEb_J6I4pgRmKt8dDKYHnMyEbSoRT9BBZ_oMT_fvMfr0-tXH07fVxbs356fri8rVTLCKc8udlY55STkQ17VE-kYpya1VgjgvmRVeeWoa51vnZNuBsta2ogHWSc-P0Ytd7jbFL3MppoeQl-5mhDhnLXhNGW1UET7_R7iJcxpLN82EFKyRgtKikjuVSzHnBJ3epjCYdKsp0QsZvdELGb2Q0QsZfU9G3xTrs_2B2Q7g_xr3KIrg5U7wNfRw-9_Bev3h_LJM_A7yzaFL</recordid><startdate>200306</startdate><enddate>200306</enddate><creator>Shima, Naoko</creator><creator>Yamaguchi, Yoshihide</creator><creator>Yuri, Kazunari</creator><general>Blackwell Publishing Ltd</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200306</creationdate><title>Distribution of estrogen receptor β mRNA‐containing cells in ovariectomized and estrogen‐treated female rat brain</title><author>Shima, Naoko ; Yamaguchi, Yoshihide ; Yuri, Kazunari</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4272-33b3cb8c2d813e0cf608d59983bb970cd82b7d9d1a5cd6cc86fe9bbb675e2f8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Amygdala</topic><topic>Animals</topic><topic>Brain - cytology</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Brain Mapping</topic><topic>Cerebellum</topic><topic>Cortex (entorhinal)</topic><topic>Cortex (olfactory)</topic><topic>Digoxigenin</topic><topic>Down-Regulation - drug effects</topic><topic>Down-Regulation - genetics</topic><topic>estradiol</topic><topic>estrogen receptor</topic><topic>Estrogen Receptor beta</topic><topic>Estrogen receptors</topic><topic>estrogen receptor‐β</topic><topic>Estrogens</topic><topic>Estrogens - metabolism</topic><topic>Estrogens - pharmacology</topic><topic>Estrous Cycle - genetics</topic><topic>Female</topic><topic>Gene expression</topic><topic>Hybridization</topic><topic>Hypothalamus</topic><topic>in situ hybridization</topic><topic>Medial geniculate body</topic><topic>Neurons - cytology</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Olfactory bulb</topic><topic>Ovariectomy</topic><topic>Purkinje cells</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Estrogen - genetics</topic><topic>RNA probes</topic><topic>RNA, Messenger - drug effects</topic><topic>RNA, Messenger - metabolism</topic><topic>Sexual Behavior - drug effects</topic><topic>Sexual Behavior - physiology</topic><topic>steroid</topic><topic>Suprachiasmatic nucleus</topic><topic>Thalamus</topic><topic>Xenoestrogens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shima, Naoko</creatorcontrib><creatorcontrib>Yamaguchi, Yoshihide</creatorcontrib><creatorcontrib>Yuri, Kazunari</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Anatomical Science International</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shima, Naoko</au><au>Yamaguchi, Yoshihide</au><au>Yuri, Kazunari</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of estrogen receptor β mRNA‐containing cells in ovariectomized and estrogen‐treated female rat brain</atitle><jtitle>Anatomical Science International</jtitle><addtitle>Anat Sci Int</addtitle><date>2003-06</date><risdate>2003</risdate><volume>78</volume><issue>2</issue><spage>85</spage><epage>97</epage><pages>85-97</pages><issn>1447-6959</issn><issn>0022-7722</issn><eissn>1447-073X</eissn><abstract>Estrogen receptor (ER)‐β is a member of the nuclear receptor superfamily and mediates various estrogenic actions. Changes in ER‐α mRNA expression induced by estrogen have been well documented, whereas those with regard to ER‐β have only been reported for a part of the hypothalamus. In the present study, we examined the effect of estrogen on ER‐β mRNA expression in the female rat brain. Detection of ER‐β mRNA using the in situ hybridization method with a digoxigenin‐labeled RNA probe was performed in two groups of female rats: ovariectomized (OVX) and estrogen (E2)‐treated. A wide distribution of ER‐β mRNA‐containing cells was demonstrated in both groups. In the E2‐treated group compared with the OVX group, the number of ER‐β mRNA‐containing cells was significantly reduced in the external plexiform layer of the olfactory bulb, entorhinal cortex, intermediate part of the lateral septal nucleus, nucleus of the horizontal limb of the diagonal band, amygdala (lateral, medial and basolateral part), thalamus (anteroventral, laterodorsal and lateral posterior part), medial geniculate nucleus, suprachiasmatic nucleus and Purkinje cells in the cerebellum. These results reveal that ER‐β mRNA‐containing cells were decreased by estrogen in several brain regions in the female rat brain, suggesting that ER‐β mRNA is downregulated by the physiological level of estrogen in a region‐specific manner.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>12828421</pmid><doi>10.1046/j.0022-7722.2003.00042.x</doi><tpages>13</tpages></addata></record> |
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| ispartof | Anatomical Science International, 2003-06, Vol.78 (2), p.85-97 |
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| subjects | Amygdala Animals Brain - cytology Brain - drug effects Brain - metabolism Brain Mapping Cerebellum Cortex (entorhinal) Cortex (olfactory) Digoxigenin Down-Regulation - drug effects Down-Regulation - genetics estradiol estrogen receptor Estrogen Receptor beta Estrogen receptors estrogen receptor‐β Estrogens Estrogens - metabolism Estrogens - pharmacology Estrous Cycle - genetics Female Gene expression Hybridization Hypothalamus in situ hybridization Medial geniculate body Neurons - cytology Neurons - drug effects Neurons - metabolism Olfactory bulb Ovariectomy Purkinje cells Rats Rats, Wistar Receptors, Estrogen - genetics RNA probes RNA, Messenger - drug effects RNA, Messenger - metabolism Sexual Behavior - drug effects Sexual Behavior - physiology steroid Suprachiasmatic nucleus Thalamus Xenoestrogens |
| title | Distribution of estrogen receptor β mRNA‐containing cells in ovariectomized and estrogen‐treated female rat brain |
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