The clinicopathologic patterns of prostatic diseases and prostate cancer in Saudi patients
To determine the clinicopathologic patterns of prostatic diseases in Saudi patients, with special emphasis on prostate cancer (PCa). The records of patients who underwent histopathological examinations of their prostatic specimens in King Abdulaziz University Medical City and King Faisal Specialist...
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| Veröffentlicht in: | Saudi medical journal 2009-11, Vol.30 (11), p.1439-1443 |
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| creator | MOSLI, Hisham A ABDEL-MEGUID, Taha A AL-MAGHRABI, Jaudah A KAMAL, Wisam K SAADAH, Hisham A FARSI, Hasan M |
| description | To determine the clinicopathologic patterns of prostatic diseases in Saudi patients, with special emphasis on prostate cancer (PCa).
The records of patients who underwent histopathological examinations of their prostatic specimens in King Abdulaziz University Medical City and King Faisal Specialist Hospital, Jeddah, Kingdom of Saudi Arabia, between June 2003 and June 2008 were reviewed retrospectively. The age, indications for biopsy, histological diagnosis, and Gleason grading of cancer patients, were studied.
The study included 330 patients aged 37-100 years (median=68). Specimens included 233 transrectal ultrasound (TRUS) biopsies, 85 transurethral resection of the prostate (TURP), 8 simple prostatectomies, 3 radical prostatectomies, and one radical cystoprostatectomy. Indications for TRUS guided biopsy in PCa patients were elevated prostate specific antigen (PSA) (85.2%), abnormal digital rectal examination (5.5%) or both (9.3%). Prostate specific antigen values or = 6 was found in 92.8% of patients.
The incidence of prostate cancer in Saudi Arabia is low compared to the western countries. However, incidental PCa detected in presumed benign disease appears to be rising. Further future studies addressing this issue are needed to confirm the potential rising trend, and its possible etiology. Our findings support the recommendations to lower the PSA cutoff value for prostatic biopsy to 2.5 rather than 4 ng/ml. |
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The records of patients who underwent histopathological examinations of their prostatic specimens in King Abdulaziz University Medical City and King Faisal Specialist Hospital, Jeddah, Kingdom of Saudi Arabia, between June 2003 and June 2008 were reviewed retrospectively. The age, indications for biopsy, histological diagnosis, and Gleason grading of cancer patients, were studied.
The study included 330 patients aged 37-100 years (median=68). Specimens included 233 transrectal ultrasound (TRUS) biopsies, 85 transurethral resection of the prostate (TURP), 8 simple prostatectomies, 3 radical prostatectomies, and one radical cystoprostatectomy. Indications for TRUS guided biopsy in PCa patients were elevated prostate specific antigen (PSA) (85.2%), abnormal digital rectal examination (5.5%) or both (9.3%). Prostate specific antigen values <4 ng/ml were found in 13.6% of PCa patients. Among others, adenocarcinoma was found in 28.5%, benign prostatic hyperplasia (BPH) alone in 43.3%, BPH with inflammation in 20.3% and inflammation alone in 4.2%. In specimens of TURP or simple prostatectomy for apparently benign disease, incidental PCa was detected in 14/93 (15%). The Gleason sum of > or = 6 was found in 92.8% of patients.
The incidence of prostate cancer in Saudi Arabia is low compared to the western countries. However, incidental PCa detected in presumed benign disease appears to be rising. Further future studies addressing this issue are needed to confirm the potential rising trend, and its possible etiology. Our findings support the recommendations to lower the PSA cutoff value for prostatic biopsy to 2.5 rather than 4 ng/ml.</description><identifier>ISSN: 0379-5284</identifier><identifier>PMID: 19882057</identifier><identifier>CODEN: SAMJDI</identifier><language>eng</language><publisher>Riyadh: Saudi Medical Journal</publisher><subject>Adenocarcinoma - diagnostic imaging ; Adenocarcinoma - epidemiology ; Adenocarcinoma - pathology ; Adenocarcinoma - surgery ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biopsy, Needle ; Cohort Studies ; Endosonography ; General aspects ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Male ; Male genital diseases ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Prognosis ; Prostate-Specific Antigen - blood ; Prostatectomy - methods ; Prostatic Hyperplasia - diagnostic imaging ; Prostatic Hyperplasia - epidemiology ; Prostatic Hyperplasia - pathology ; Prostatic Hyperplasia - surgery ; Prostatic Neoplasms - diagnostic imaging ; Prostatic Neoplasms - epidemiology ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; Reference Values ; Risk Assessment ; Saudi Arabia - epidemiology ; Survival Analysis ; Transurethral Resection of Prostate ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland</subject><ispartof>Saudi medical journal, 2009-11, Vol.30 (11), p.1439-1443</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22235055$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19882057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MOSLI, Hisham A</creatorcontrib><creatorcontrib>ABDEL-MEGUID, Taha A</creatorcontrib><creatorcontrib>AL-MAGHRABI, Jaudah A</creatorcontrib><creatorcontrib>KAMAL, Wisam K</creatorcontrib><creatorcontrib>SAADAH, Hisham A</creatorcontrib><creatorcontrib>FARSI, Hasan M</creatorcontrib><title>The clinicopathologic patterns of prostatic diseases and prostate cancer in Saudi patients</title><title>Saudi medical journal</title><addtitle>Saudi Med J</addtitle><description>To determine the clinicopathologic patterns of prostatic diseases in Saudi patients, with special emphasis on prostate cancer (PCa).
The records of patients who underwent histopathological examinations of their prostatic specimens in King Abdulaziz University Medical City and King Faisal Specialist Hospital, Jeddah, Kingdom of Saudi Arabia, between June 2003 and June 2008 were reviewed retrospectively. The age, indications for biopsy, histological diagnosis, and Gleason grading of cancer patients, were studied.
The study included 330 patients aged 37-100 years (median=68). Specimens included 233 transrectal ultrasound (TRUS) biopsies, 85 transurethral resection of the prostate (TURP), 8 simple prostatectomies, 3 radical prostatectomies, and one radical cystoprostatectomy. Indications for TRUS guided biopsy in PCa patients were elevated prostate specific antigen (PSA) (85.2%), abnormal digital rectal examination (5.5%) or both (9.3%). Prostate specific antigen values <4 ng/ml were found in 13.6% of PCa patients. Among others, adenocarcinoma was found in 28.5%, benign prostatic hyperplasia (BPH) alone in 43.3%, BPH with inflammation in 20.3% and inflammation alone in 4.2%. In specimens of TURP or simple prostatectomy for apparently benign disease, incidental PCa was detected in 14/93 (15%). The Gleason sum of > or = 6 was found in 92.8% of patients.
The incidence of prostate cancer in Saudi Arabia is low compared to the western countries. However, incidental PCa detected in presumed benign disease appears to be rising. Further future studies addressing this issue are needed to confirm the potential rising trend, and its possible etiology. Our findings support the recommendations to lower the PSA cutoff value for prostatic biopsy to 2.5 rather than 4 ng/ml.</description><subject>Adenocarcinoma - diagnostic imaging</subject><subject>Adenocarcinoma - epidemiology</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - surgery</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>Cohort Studies</subject><subject>Endosonography</subject><subject>General aspects</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Prognosis</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostatectomy - methods</subject><subject>Prostatic Hyperplasia - diagnostic imaging</subject><subject>Prostatic Hyperplasia - epidemiology</subject><subject>Prostatic Hyperplasia - pathology</subject><subject>Prostatic Hyperplasia - surgery</subject><subject>Prostatic Neoplasms - diagnostic imaging</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Reference Values</subject><subject>Risk Assessment</subject><subject>Saudi Arabia - epidemiology</subject><subject>Survival Analysis</subject><subject>Transurethral Resection of Prostate</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><issn>0379-5284</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtPw0AQhF2ASAj8BXQNorK0vpftEkW8pEgUhIbGuic55JyN91zw77mIhGpXo29WM3tWLIHVbSlowxfFJeIXAJMS5EWxqNqmoSDqZfGx3Tli-hCDGUaVdkM_fAZD8prcFJEMnozTgEmlrNqATqFDoqI9ydmtonETCZG8qdmGgze4mPCqOPeqR3d9nKvi_fFhu34uN69PL-v7TTlSDqnkdQ4DlDKQDHzjmayobamQAkxTccvBWyXAO65VC5XTreZSaNCi5pxqxlbF3d_dnOh7dpi6fUDj-l5FN8zY1YxXh7JNJm-O5Kz3znbjFPZq-ulO78jA7RFQaFTvp1wt4D9Hc0oBQrBfkMxnmw</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>MOSLI, Hisham A</creator><creator>ABDEL-MEGUID, Taha A</creator><creator>AL-MAGHRABI, Jaudah A</creator><creator>KAMAL, Wisam K</creator><creator>SAADAH, Hisham A</creator><creator>FARSI, Hasan M</creator><general>Saudi Medical Journal</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>The clinicopathologic patterns of prostatic diseases and prostate cancer in Saudi patients</title><author>MOSLI, Hisham A ; ABDEL-MEGUID, Taha A ; AL-MAGHRABI, Jaudah A ; KAMAL, Wisam K ; SAADAH, Hisham A ; FARSI, Hasan M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p240t-4798802230630f8f3612d925650c814d40fda50fe4ba901eb9b465b0b57442b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adenocarcinoma - diagnostic imaging</topic><topic>Adenocarcinoma - epidemiology</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - surgery</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>Cohort Studies</topic><topic>Endosonography</topic><topic>General aspects</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Prognosis</topic><topic>Prostate-Specific Antigen - blood</topic><topic>Prostatectomy - methods</topic><topic>Prostatic Hyperplasia - diagnostic imaging</topic><topic>Prostatic Hyperplasia - epidemiology</topic><topic>Prostatic Hyperplasia - pathology</topic><topic>Prostatic Hyperplasia - surgery</topic><topic>Prostatic Neoplasms - diagnostic imaging</topic><topic>Prostatic Neoplasms - epidemiology</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Reference Values</topic><topic>Risk Assessment</topic><topic>Saudi Arabia - epidemiology</topic><topic>Survival Analysis</topic><topic>Transurethral Resection of Prostate</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MOSLI, Hisham A</creatorcontrib><creatorcontrib>ABDEL-MEGUID, Taha A</creatorcontrib><creatorcontrib>AL-MAGHRABI, Jaudah A</creatorcontrib><creatorcontrib>KAMAL, Wisam K</creatorcontrib><creatorcontrib>SAADAH, Hisham A</creatorcontrib><creatorcontrib>FARSI, Hasan M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Saudi medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MOSLI, Hisham A</au><au>ABDEL-MEGUID, Taha A</au><au>AL-MAGHRABI, Jaudah A</au><au>KAMAL, Wisam K</au><au>SAADAH, Hisham A</au><au>FARSI, Hasan M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The clinicopathologic patterns of prostatic diseases and prostate cancer in Saudi patients</atitle><jtitle>Saudi medical journal</jtitle><addtitle>Saudi Med J</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>30</volume><issue>11</issue><spage>1439</spage><epage>1443</epage><pages>1439-1443</pages><issn>0379-5284</issn><coden>SAMJDI</coden><abstract>To determine the clinicopathologic patterns of prostatic diseases in Saudi patients, with special emphasis on prostate cancer (PCa).
The records of patients who underwent histopathological examinations of their prostatic specimens in King Abdulaziz University Medical City and King Faisal Specialist Hospital, Jeddah, Kingdom of Saudi Arabia, between June 2003 and June 2008 were reviewed retrospectively. The age, indications for biopsy, histological diagnosis, and Gleason grading of cancer patients, were studied.
The study included 330 patients aged 37-100 years (median=68). Specimens included 233 transrectal ultrasound (TRUS) biopsies, 85 transurethral resection of the prostate (TURP), 8 simple prostatectomies, 3 radical prostatectomies, and one radical cystoprostatectomy. Indications for TRUS guided biopsy in PCa patients were elevated prostate specific antigen (PSA) (85.2%), abnormal digital rectal examination (5.5%) or both (9.3%). Prostate specific antigen values <4 ng/ml were found in 13.6% of PCa patients. Among others, adenocarcinoma was found in 28.5%, benign prostatic hyperplasia (BPH) alone in 43.3%, BPH with inflammation in 20.3% and inflammation alone in 4.2%. In specimens of TURP or simple prostatectomy for apparently benign disease, incidental PCa was detected in 14/93 (15%). The Gleason sum of > or = 6 was found in 92.8% of patients.
The incidence of prostate cancer in Saudi Arabia is low compared to the western countries. However, incidental PCa detected in presumed benign disease appears to be rising. Further future studies addressing this issue are needed to confirm the potential rising trend, and its possible etiology. Our findings support the recommendations to lower the PSA cutoff value for prostatic biopsy to 2.5 rather than 4 ng/ml.</abstract><cop>Riyadh</cop><pub>Saudi Medical Journal</pub><pmid>19882057</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Saudi medical journal, 2009-11, Vol.30 (11), p.1439-1443 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adenocarcinoma - diagnostic imaging Adenocarcinoma - epidemiology Adenocarcinoma - pathology Adenocarcinoma - surgery Adult Age Factors Aged Aged, 80 and over Biological and medical sciences Biopsy, Needle Cohort Studies Endosonography General aspects Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Male Male genital diseases Medical sciences Middle Aged Nephrology. Urinary tract diseases Prognosis Prostate-Specific Antigen - blood Prostatectomy - methods Prostatic Hyperplasia - diagnostic imaging Prostatic Hyperplasia - epidemiology Prostatic Hyperplasia - pathology Prostatic Hyperplasia - surgery Prostatic Neoplasms - diagnostic imaging Prostatic Neoplasms - epidemiology Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Reference Values Risk Assessment Saudi Arabia - epidemiology Survival Analysis Transurethral Resection of Prostate Tumors Tumors of the urinary system Urinary tract. Prostate gland |
| title | The clinicopathologic patterns of prostatic diseases and prostate cancer in Saudi patients |
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