Genotype of the CYBA promoter −930A/G, polymorphism C677T of the MTHFR and APOE genotype in patients with hypertensive disorders of pregnancy: An observational study
Abstract Background and objective Hypertensive disorders of pregnancy could be favoured by polymorphisms in genes affecting vascular physiology. The aim of our work was to study several variants in the genes regulating oxidative stress, plasma lipids metabolism and endothelial function (observationa...
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| Veröffentlicht in: | Medicina clínica 2009-11, Vol.133 (17), p.657-661 |
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| creator | Stiefel, Pablo Miranda, María Luisa Bellido, Lola M Luna, Jerónimo Jiménez, Luis Pamies, Encarnación de Frutos, Pablo García Villar, José |
| description | Abstract Background and objective Hypertensive disorders of pregnancy could be favoured by polymorphisms in genes affecting vascular physiology. The aim of our work was to study several variants in the genes regulating oxidative stress, plasma lipids metabolism and endothelial function (observational study). Material and methods We studied the −930A/G polymorphism of the CYBA gene promoter, the apolipoprotein E (APOE) genotype and the methylene-tetrahydrofolate reductase (MTHFR) gene C677T polymorphism in 134 healthy pregnant women, 266 pregnant with non-proteinuric hypertension (NPH) and 184 patients with preeclampsia (PE). Results The GG genotype of the CYBA gene promoter was present in 32.1% of the control population, 38.7% of patients with NPH ( P =0.19) and 21.2% of the women with PE ( P =0.03). A higher frequency of ∈3/∈4 and ∈4/∈4 genotypes of APOE was observed in patients with PE or NPH compared with controls ( P |
| doi_str_mv | 10.1016/j.medcli.2009.03.042 |
| format | Article |
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The aim of our work was to study several variants in the genes regulating oxidative stress, plasma lipids metabolism and endothelial function (observational study). Material and methods We studied the −930A/G polymorphism of the CYBA gene promoter, the apolipoprotein E (APOE) genotype and the methylene-tetrahydrofolate reductase (MTHFR) gene C677T polymorphism in 134 healthy pregnant women, 266 pregnant with non-proteinuric hypertension (NPH) and 184 patients with preeclampsia (PE). Results The GG genotype of the CYBA gene promoter was present in 32.1% of the control population, 38.7% of patients with NPH ( P =0.19) and 21.2% of the women with PE ( P =0.03). A higher frequency of ∈3/∈4 and ∈4/∈4 genotypes of APOE was observed in patients with PE or NPH compared with controls ( P <0.01). There were no significant differences detected in genotype or allele distribution of the MTHFR, C677T polymorphism. APOE ∈3/∈4 and ∈4/∈4 genotypes had a worse lipoprotein profile characterized by higher plasma values of total cholesterol ( P <0.05) and triglycerides ( P <0.005). Despite no differences in MTHFR C677T polymorphism distribution, higher levels of plasma homocysteine were observed in patients with PE than in patients with NPH or controls. Conclusions CYBA and APOE polymorphism showed a different distribution in the groups studied, while no differences were observed in MTHFR C677T polymorphism. APOE genotype was associated with changes in lipid and lipoprotein profiles in pregnant women.</description><identifier>ISSN: 0025-7753</identifier><identifier>DOI: 10.1016/j.medcli.2009.03.042</identifier><identifier>PMID: 19853876</identifier><language>eng</language><publisher>Spain: Elsevier Espana</publisher><subject>Adult ; Apolipoprotein E ; Apolipoproteins E - genetics ; CYBA ; Female ; Genotype ; Gestational hypertension ; Hipertensión Gestacional ; Humans ; Hypertension - genetics ; Internal Medicine ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; MTHFR ; NADPH Oxidases - genetics ; P22phox ; Polimorfismo ; Polymorphism ; Polymorphism, Genetic ; Preeclampsia ; Pregnancy ; Pregnancy Complications, Cardiovascular - genetics</subject><ispartof>Medicina clínica, 2009-11, Vol.133 (17), p.657-661</ispartof><rights>Elsevier España, S.L</rights><rights>2009 Elsevier España, S.L</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-46723bf8ab543a7476e19e38c0b79723959d5eb4dad1b0358d24a06e937b13863</citedby><cites>FETCH-LOGICAL-c416t-46723bf8ab543a7476e19e38c0b79723959d5eb4dad1b0358d24a06e937b13863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0025775309012627$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19853876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stiefel, Pablo</creatorcontrib><creatorcontrib>Miranda, María Luisa</creatorcontrib><creatorcontrib>Bellido, Lola M</creatorcontrib><creatorcontrib>Luna, Jerónimo</creatorcontrib><creatorcontrib>Jiménez, Luis</creatorcontrib><creatorcontrib>Pamies, Encarnación</creatorcontrib><creatorcontrib>de Frutos, Pablo García</creatorcontrib><creatorcontrib>Villar, José</creatorcontrib><title>Genotype of the CYBA promoter −930A/G, polymorphism C677T of the MTHFR and APOE genotype in patients with hypertensive disorders of pregnancy: An observational study</title><title>Medicina clínica</title><addtitle>Med Clin (Barc)</addtitle><description>Abstract Background and objective Hypertensive disorders of pregnancy could be favoured by polymorphisms in genes affecting vascular physiology. The aim of our work was to study several variants in the genes regulating oxidative stress, plasma lipids metabolism and endothelial function (observational study). Material and methods We studied the −930A/G polymorphism of the CYBA gene promoter, the apolipoprotein E (APOE) genotype and the methylene-tetrahydrofolate reductase (MTHFR) gene C677T polymorphism in 134 healthy pregnant women, 266 pregnant with non-proteinuric hypertension (NPH) and 184 patients with preeclampsia (PE). Results The GG genotype of the CYBA gene promoter was present in 32.1% of the control population, 38.7% of patients with NPH ( P =0.19) and 21.2% of the women with PE ( P =0.03). A higher frequency of ∈3/∈4 and ∈4/∈4 genotypes of APOE was observed in patients with PE or NPH compared with controls ( P <0.01). There were no significant differences detected in genotype or allele distribution of the MTHFR, C677T polymorphism. APOE ∈3/∈4 and ∈4/∈4 genotypes had a worse lipoprotein profile characterized by higher plasma values of total cholesterol ( P <0.05) and triglycerides ( P <0.005). Despite no differences in MTHFR C677T polymorphism distribution, higher levels of plasma homocysteine were observed in patients with PE than in patients with NPH or controls. Conclusions CYBA and APOE polymorphism showed a different distribution in the groups studied, while no differences were observed in MTHFR C677T polymorphism. APOE genotype was associated with changes in lipid and lipoprotein profiles in pregnant women.</description><subject>Adult</subject><subject>Apolipoprotein E</subject><subject>Apolipoproteins E - genetics</subject><subject>CYBA</subject><subject>Female</subject><subject>Genotype</subject><subject>Gestational hypertension</subject><subject>Hipertensión Gestacional</subject><subject>Humans</subject><subject>Hypertension - genetics</subject><subject>Internal Medicine</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>MTHFR</subject><subject>NADPH Oxidases - genetics</subject><subject>P22phox</subject><subject>Polimorfismo</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Cardiovascular - genetics</subject><issn>0025-7753</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUsFu1DAQzQFES-EPEPKNC5vacRInHJDCqt0iFRXBcuBkOfZs10tip7azKH_AmZ_of_EldbRbIXHhNPLMe2_k9yZJXhGcEkzK813ag5KdTjOM6xTTFOfZk-QU46xYMFbQk-S597v5SQl7lpyQuipoxcrT5H4FxoZpAGQ3KGwBLb9_aNDgbG8DOPTn1--a4uZ89RYNtpt664at9j1aloytHymf1leXX5AwCjWfby7Q7aOiNmgQQYMJHv3UYYu2sesCGK_3gJT21ilwfpYZHNwaYeT0DjUG2daD20eqNaJDPoxqepE83YjOw8tjPUu-XV6sl1eL65vVx2VzvZA5KcMiL1lG200l2iKnguWsBFIDrSRuWR1HdVGrAtpcCUVaTItKZbnAJdSUtYRWJT1L3hx0owV3I_jAe-0ldJ0wYEfPGc0JqYsqi8j8gJTOeu9gwwene-EmTjCfU-E7fkiFz6lwTHlMJdJeHxeMbRz_JR0jiYD3BwDEb-41OO5l9FCC0g5k4Mrq_234VyAijJai-wET-J0dXbTVc8J9xjH_Op_FfCS4xiQrM0YfACLht6Q</recordid><startdate>20091107</startdate><enddate>20091107</enddate><creator>Stiefel, Pablo</creator><creator>Miranda, María Luisa</creator><creator>Bellido, Lola M</creator><creator>Luna, Jerónimo</creator><creator>Jiménez, Luis</creator><creator>Pamies, Encarnación</creator><creator>de Frutos, Pablo García</creator><creator>Villar, José</creator><general>Elsevier Espana</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091107</creationdate><title>Genotype of the CYBA promoter −930A/G, polymorphism C677T of the MTHFR and APOE genotype in patients with hypertensive disorders of pregnancy: An observational study</title><author>Stiefel, Pablo ; Miranda, María Luisa ; Bellido, Lola M ; Luna, Jerónimo ; Jiménez, Luis ; Pamies, Encarnación ; de Frutos, Pablo García ; Villar, José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-46723bf8ab543a7476e19e38c0b79723959d5eb4dad1b0358d24a06e937b13863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Apolipoprotein E</topic><topic>Apolipoproteins E - genetics</topic><topic>CYBA</topic><topic>Female</topic><topic>Genotype</topic><topic>Gestational hypertension</topic><topic>Hipertensión Gestacional</topic><topic>Humans</topic><topic>Hypertension - genetics</topic><topic>Internal Medicine</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>MTHFR</topic><topic>NADPH Oxidases - genetics</topic><topic>P22phox</topic><topic>Polimorfismo</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Cardiovascular - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stiefel, Pablo</creatorcontrib><creatorcontrib>Miranda, María Luisa</creatorcontrib><creatorcontrib>Bellido, Lola M</creatorcontrib><creatorcontrib>Luna, Jerónimo</creatorcontrib><creatorcontrib>Jiménez, Luis</creatorcontrib><creatorcontrib>Pamies, Encarnación</creatorcontrib><creatorcontrib>de Frutos, Pablo García</creatorcontrib><creatorcontrib>Villar, José</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medicina clínica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stiefel, Pablo</au><au>Miranda, María Luisa</au><au>Bellido, Lola M</au><au>Luna, Jerónimo</au><au>Jiménez, Luis</au><au>Pamies, Encarnación</au><au>de Frutos, Pablo García</au><au>Villar, José</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genotype of the CYBA promoter −930A/G, polymorphism C677T of the MTHFR and APOE genotype in patients with hypertensive disorders of pregnancy: An observational study</atitle><jtitle>Medicina clínica</jtitle><addtitle>Med Clin (Barc)</addtitle><date>2009-11-07</date><risdate>2009</risdate><volume>133</volume><issue>17</issue><spage>657</spage><epage>661</epage><pages>657-661</pages><issn>0025-7753</issn><abstract>Abstract Background and objective Hypertensive disorders of pregnancy could be favoured by polymorphisms in genes affecting vascular physiology. The aim of our work was to study several variants in the genes regulating oxidative stress, plasma lipids metabolism and endothelial function (observational study). Material and methods We studied the −930A/G polymorphism of the CYBA gene promoter, the apolipoprotein E (APOE) genotype and the methylene-tetrahydrofolate reductase (MTHFR) gene C677T polymorphism in 134 healthy pregnant women, 266 pregnant with non-proteinuric hypertension (NPH) and 184 patients with preeclampsia (PE). Results The GG genotype of the CYBA gene promoter was present in 32.1% of the control population, 38.7% of patients with NPH ( P =0.19) and 21.2% of the women with PE ( P =0.03). A higher frequency of ∈3/∈4 and ∈4/∈4 genotypes of APOE was observed in patients with PE or NPH compared with controls ( P <0.01). There were no significant differences detected in genotype or allele distribution of the MTHFR, C677T polymorphism. APOE ∈3/∈4 and ∈4/∈4 genotypes had a worse lipoprotein profile characterized by higher plasma values of total cholesterol ( P <0.05) and triglycerides ( P <0.005). Despite no differences in MTHFR C677T polymorphism distribution, higher levels of plasma homocysteine were observed in patients with PE than in patients with NPH or controls. Conclusions CYBA and APOE polymorphism showed a different distribution in the groups studied, while no differences were observed in MTHFR C677T polymorphism. APOE genotype was associated with changes in lipid and lipoprotein profiles in pregnant women.</abstract><cop>Spain</cop><pub>Elsevier Espana</pub><pmid>19853876</pmid><doi>10.1016/j.medcli.2009.03.042</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Apolipoprotein E Apolipoproteins E - genetics CYBA Female Genotype Gestational hypertension Hipertensión Gestacional Humans Hypertension - genetics Internal Medicine Methylenetetrahydrofolate Reductase (NADPH2) - genetics MTHFR NADPH Oxidases - genetics P22phox Polimorfismo Polymorphism Polymorphism, Genetic Preeclampsia Pregnancy Pregnancy Complications, Cardiovascular - genetics |
| title | Genotype of the CYBA promoter −930A/G, polymorphism C677T of the MTHFR and APOE genotype in patients with hypertensive disorders of pregnancy: An observational study |
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