Sevoflurane Postconditioning Protects Chronically-Infarcted Rat Hearts against Ischemia-Reperfusion Injury by Activation of Pro-survival Kinases and Inhibition of Mitochondrial Permeability Transition Pore Opening upon Reperfusion

We evaluated the cardioprotection against myocardial ischemia-reperfusion injury induced by sevoflurane postconditioning (SpostC) in chronically-infarcted rat hearts, and investigated the roles of phosphoinositide 3-kinase (PI3K)-protein kinase B/Akt (PKB/Akt), mitogen-activated extracellular regula...

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Veröffentlicht in:	Biological & Pharmaceutical Bullein 2009/11/01, Vol.32(11), pp.1854-1861
Hauptverfasser:	Yao, Yuntai, Li, Lihuan, Li, Libing, Gao, Changqing, Shi, Chunxia
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Inhalation - pharmacology Animals Blotting, Western Enzyme Activation heart ischemia-reperfusion injury Male Methyl Ethers - pharmacology Mitochondria, Heart - drug effects mitochondrial permeability transition pore Myocardial Infarction - complications Permeability Protein Kinases - metabolism Rats Rats, Sprague-Dawley Reperfusion Injury - prevention & control reperfusion injury salvage kinase Sevoflurane
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