Induction of granulysin in CD8+ T cells by IL-21 and IL-15 is suppressed by human immunodeficiency virus-1

PBMC infected with HIV‐1 inhibit cytokine signaling and antimicrobial protein expression in human CD8+ T cells. Immunosuppression following infection with HIV‐1 predisposes patients to a myriad of opportunistic pathogens, one of the most important of which is Mtb. Granulysin, expressed by NK cells a...

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Veröffentlicht in:	Journal of leukocyte biology 2009-11, Vol.86 (5), p.1191-1203
Hauptverfasser:	Hogg, A. E., Bowick, G. C., Herzog, N. K., Cloyd, M. W., Endsley, J. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - immunology Antigens, Differentiation, T-Lymphocyte - biosynthesis Antigens, Differentiation, T-Lymphocyte - blood Antigens, Differentiation, T-Lymphocyte - genetics Antigens, Differentiation, T-Lymphocyte - physiology CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cell Survival - immunology cytokines cytotoxicity Flow Cytometry Gene Expression Regulation HIV-1 - immunology human Humans Immunity, Cellular Immunosuppression Interleukin-15 - pharmacology Interleukin-2 - pharmacology Interleukins - pharmacology Leukocyte Common Antigens - immunology Lymphocyte Activation - immunology Phosphorylation Reference Values Signal Transduction
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