11C-PK11195 PET for the In Vivo Evaluation of Neuroinflammation in the Rat Brain After Cortical Spreading Depression

Neurogenic inflammation triggered by extravasation of plasma protein has been hypothesized as a key factor in the generation of the pain sensation associated with migraine. The principal immune cell that responds to this inflammation is the parenchymal microglia of the central nervous system. Using...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2009-11, Vol.50 (11), p.1904-1911
Hauptverfasser:	Cui, Yilong, Takashima, Tadayuki, Takashima-Hirano, Misato, Wada, Yasuhiro, Shukuri, Miho, Tamura, Yasuhisa, Doi, Hisashi, Onoe, Hirotaka, Kataoka, Yosky, Watanabe, Yasuyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Animals Cerebral Cortex - diagnostic imaging Cerebral Cortex - physiopathology Cortical Spreading Depression Immunohistochemistry Isoquinolines Male Neurogenic Inflammation - diagnostic imaging Neurogenic Inflammation - physiopathology Positron-Emission Tomography Rats Rats, Sprague-Dawley
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