11C-PK11195 PET for the In Vivo Evaluation of Neuroinflammation in the Rat Brain After Cortical Spreading Depression
Neurogenic inflammation triggered by extravasation of plasma protein has been hypothesized as a key factor in the generation of the pain sensation associated with migraine. The principal immune cell that responds to this inflammation is the parenchymal microglia of the central nervous system. Using...
Gespeichert in:
| Veröffentlicht in: | The Journal of nuclear medicine (1978) 2009-11, Vol.50 (11), p.1904-1911 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1911 |
|---|---|
| container_issue | 11 |
| container_start_page | 1904 |
| container_title | The Journal of nuclear medicine (1978) |
| container_volume | 50 |
| creator | Cui, Yilong Takashima, Tadayuki Takashima-Hirano, Misato Wada, Yasuhiro Shukuri, Miho Tamura, Yasuhisa Doi, Hisashi Onoe, Hirotaka Kataoka, Yosky Watanabe, Yasuyoshi |
| description | Neurogenic inflammation triggered by extravasation of plasma protein has been hypothesized as a key factor in the generation of the pain sensation associated with migraine. The principal immune cell that responds to this inflammation is the parenchymal microglia of the central nervous system.
Using a PET technique with (11)C-(R)-[1-(2-chlorophenyl)-N-methyl-N-(1-methyl-propyl)-3-isoquinolinecarboxamide] ((11)C-PK11195), a PET ligand for peripheral type-benzodiazepine receptor, we evaluated the microglial activation in the rat brain after generation of unilateral cortical spreading depression, a stimulation used to bring up an experimental animal model of migraine.
We found a significant increase in the brain uptake of (11)C-PK11195, which was completely displaceable by the excess amounts of unlabeled ligands, in the ipsilateral hemisphere of the spreading depression-generated rats. Moreover, the binding potential of (11)C-PK11195 in the spreading depression-generated rats was significantly higher than that in the sham-operated control rats.
These results suggest that as an inflammatory reaction, microglial cells are activated in response to the nociceptive stimuli induced by cortical spreading depression in the rat brain. Therefore, the (11)C-PK11195 PET technique could have a potential for diagnostic and therapeutic monitoring of neurologic disorders related to neuroinflammation such as migraine. |
| doi_str_mv | 10.2967/jnumed.109.066498 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_734115706</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>734115706</sourcerecordid><originalsourceid>FETCH-LOGICAL-h1978-fc525a300eb3d236eeea1b404c880b4d6ac43b8d9c7815a2d70e715523b51bb73</originalsourceid><addsrcrecordid>eNo10D1v2zAQBmCiaFC7SX5AloBbu8jliTqSGhPXbY0aidE6WQVKOsU0JMqhJBf591FjZ7oPPHfDy9gViFmcKv1t54eGyhmIdCaUSlLzgU0BJUaolP7IpgIURIgCJ-xz1-2EEMoY84lNIDVSa8Qp6wHm0fo3AKTI14sNr9rA-y3xpeeP7tDyxcHWg-1d63lb8TsaQut8VdumOS6df-N_bM9vgx2nm6qnwOdt6F1ha_53H8iWzj_x7zS2XTceXbCzytYdXZ7qOXv4sdjMf0Wr-5_L-c0q2kKqTVQVGKOVQlAuy1gqIrKQJyIpjBF5UipbJDI3ZVpoA2jjUgvSgBjLHCHPtTxnX45_96F9Hqjrs8Z1BdW19dQOXaZlAoBaqFFen-SQj5Fm--AaG16y96BG8PUItu5p-88FyvxQ1GTDf73zDYoMYOQika_jNXgU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>734115706</pqid></control><display><type>article</type><title>11C-PK11195 PET for the In Vivo Evaluation of Neuroinflammation in the Rat Brain After Cortical Spreading Depression</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Cui, Yilong ; Takashima, Tadayuki ; Takashima-Hirano, Misato ; Wada, Yasuhiro ; Shukuri, Miho ; Tamura, Yasuhisa ; Doi, Hisashi ; Onoe, Hirotaka ; Kataoka, Yosky ; Watanabe, Yasuyoshi</creator><creatorcontrib>Cui, Yilong ; Takashima, Tadayuki ; Takashima-Hirano, Misato ; Wada, Yasuhiro ; Shukuri, Miho ; Tamura, Yasuhisa ; Doi, Hisashi ; Onoe, Hirotaka ; Kataoka, Yosky ; Watanabe, Yasuyoshi</creatorcontrib><description>Neurogenic inflammation triggered by extravasation of plasma protein has been hypothesized as a key factor in the generation of the pain sensation associated with migraine. The principal immune cell that responds to this inflammation is the parenchymal microglia of the central nervous system.
Using a PET technique with (11)C-(R)-[1-(2-chlorophenyl)-N-methyl-N-(1-methyl-propyl)-3-isoquinolinecarboxamide] ((11)C-PK11195), a PET ligand for peripheral type-benzodiazepine receptor, we evaluated the microglial activation in the rat brain after generation of unilateral cortical spreading depression, a stimulation used to bring up an experimental animal model of migraine.
We found a significant increase in the brain uptake of (11)C-PK11195, which was completely displaceable by the excess amounts of unlabeled ligands, in the ipsilateral hemisphere of the spreading depression-generated rats. Moreover, the binding potential of (11)C-PK11195 in the spreading depression-generated rats was significantly higher than that in the sham-operated control rats.
These results suggest that as an inflammatory reaction, microglial cells are activated in response to the nociceptive stimuli induced by cortical spreading depression in the rat brain. Therefore, the (11)C-PK11195 PET technique could have a potential for diagnostic and therapeutic monitoring of neurologic disorders related to neuroinflammation such as migraine.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>DOI: 10.2967/jnumed.109.066498</identifier><identifier>PMID: 19837755</identifier><language>eng</language><publisher>United States: Soc Nuclear Med</publisher><subject>Amides ; Animals ; Cerebral Cortex - diagnostic imaging ; Cerebral Cortex - physiopathology ; Cortical Spreading Depression ; Immunohistochemistry ; Isoquinolines ; Male ; Neurogenic Inflammation - diagnostic imaging ; Neurogenic Inflammation - physiopathology ; Positron-Emission Tomography ; Rats ; Rats, Sprague-Dawley</subject><ispartof>The Journal of nuclear medicine (1978), 2009-11, Vol.50 (11), p.1904-1911</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19837755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cui, Yilong</creatorcontrib><creatorcontrib>Takashima, Tadayuki</creatorcontrib><creatorcontrib>Takashima-Hirano, Misato</creatorcontrib><creatorcontrib>Wada, Yasuhiro</creatorcontrib><creatorcontrib>Shukuri, Miho</creatorcontrib><creatorcontrib>Tamura, Yasuhisa</creatorcontrib><creatorcontrib>Doi, Hisashi</creatorcontrib><creatorcontrib>Onoe, Hirotaka</creatorcontrib><creatorcontrib>Kataoka, Yosky</creatorcontrib><creatorcontrib>Watanabe, Yasuyoshi</creatorcontrib><title>11C-PK11195 PET for the In Vivo Evaluation of Neuroinflammation in the Rat Brain After Cortical Spreading Depression</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>Neurogenic inflammation triggered by extravasation of plasma protein has been hypothesized as a key factor in the generation of the pain sensation associated with migraine. The principal immune cell that responds to this inflammation is the parenchymal microglia of the central nervous system.
Using a PET technique with (11)C-(R)-[1-(2-chlorophenyl)-N-methyl-N-(1-methyl-propyl)-3-isoquinolinecarboxamide] ((11)C-PK11195), a PET ligand for peripheral type-benzodiazepine receptor, we evaluated the microglial activation in the rat brain after generation of unilateral cortical spreading depression, a stimulation used to bring up an experimental animal model of migraine.
We found a significant increase in the brain uptake of (11)C-PK11195, which was completely displaceable by the excess amounts of unlabeled ligands, in the ipsilateral hemisphere of the spreading depression-generated rats. Moreover, the binding potential of (11)C-PK11195 in the spreading depression-generated rats was significantly higher than that in the sham-operated control rats.
These results suggest that as an inflammatory reaction, microglial cells are activated in response to the nociceptive stimuli induced by cortical spreading depression in the rat brain. Therefore, the (11)C-PK11195 PET technique could have a potential for diagnostic and therapeutic monitoring of neurologic disorders related to neuroinflammation such as migraine.</description><subject>Amides</subject><subject>Animals</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Cortical Spreading Depression</subject><subject>Immunohistochemistry</subject><subject>Isoquinolines</subject><subject>Male</subject><subject>Neurogenic Inflammation - diagnostic imaging</subject><subject>Neurogenic Inflammation - physiopathology</subject><subject>Positron-Emission Tomography</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10D1v2zAQBmCiaFC7SX5AloBbu8jliTqSGhPXbY0aidE6WQVKOsU0JMqhJBf591FjZ7oPPHfDy9gViFmcKv1t54eGyhmIdCaUSlLzgU0BJUaolP7IpgIURIgCJ-xz1-2EEMoY84lNIDVSa8Qp6wHm0fo3AKTI14sNr9rA-y3xpeeP7tDyxcHWg-1d63lb8TsaQut8VdumOS6df-N_bM9vgx2nm6qnwOdt6F1ha_53H8iWzj_x7zS2XTceXbCzytYdXZ7qOXv4sdjMf0Wr-5_L-c0q2kKqTVQVGKOVQlAuy1gqIrKQJyIpjBF5UipbJDI3ZVpoA2jjUgvSgBjLHCHPtTxnX45_96F9Hqjrs8Z1BdW19dQOXaZlAoBaqFFen-SQj5Fm--AaG16y96BG8PUItu5p-88FyvxQ1GTDf73zDYoMYOQika_jNXgU</recordid><startdate>200911</startdate><enddate>200911</enddate><creator>Cui, Yilong</creator><creator>Takashima, Tadayuki</creator><creator>Takashima-Hirano, Misato</creator><creator>Wada, Yasuhiro</creator><creator>Shukuri, Miho</creator><creator>Tamura, Yasuhisa</creator><creator>Doi, Hisashi</creator><creator>Onoe, Hirotaka</creator><creator>Kataoka, Yosky</creator><creator>Watanabe, Yasuyoshi</creator><general>Soc Nuclear Med</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200911</creationdate><title>11C-PK11195 PET for the In Vivo Evaluation of Neuroinflammation in the Rat Brain After Cortical Spreading Depression</title><author>Cui, Yilong ; Takashima, Tadayuki ; Takashima-Hirano, Misato ; Wada, Yasuhiro ; Shukuri, Miho ; Tamura, Yasuhisa ; Doi, Hisashi ; Onoe, Hirotaka ; Kataoka, Yosky ; Watanabe, Yasuyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h1978-fc525a300eb3d236eeea1b404c880b4d6ac43b8d9c7815a2d70e715523b51bb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Amides</topic><topic>Animals</topic><topic>Cerebral Cortex - diagnostic imaging</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Cortical Spreading Depression</topic><topic>Immunohistochemistry</topic><topic>Isoquinolines</topic><topic>Male</topic><topic>Neurogenic Inflammation - diagnostic imaging</topic><topic>Neurogenic Inflammation - physiopathology</topic><topic>Positron-Emission Tomography</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cui, Yilong</creatorcontrib><creatorcontrib>Takashima, Tadayuki</creatorcontrib><creatorcontrib>Takashima-Hirano, Misato</creatorcontrib><creatorcontrib>Wada, Yasuhiro</creatorcontrib><creatorcontrib>Shukuri, Miho</creatorcontrib><creatorcontrib>Tamura, Yasuhisa</creatorcontrib><creatorcontrib>Doi, Hisashi</creatorcontrib><creatorcontrib>Onoe, Hirotaka</creatorcontrib><creatorcontrib>Kataoka, Yosky</creatorcontrib><creatorcontrib>Watanabe, Yasuyoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cui, Yilong</au><au>Takashima, Tadayuki</au><au>Takashima-Hirano, Misato</au><au>Wada, Yasuhiro</au><au>Shukuri, Miho</au><au>Tamura, Yasuhisa</au><au>Doi, Hisashi</au><au>Onoe, Hirotaka</au><au>Kataoka, Yosky</au><au>Watanabe, Yasuyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>11C-PK11195 PET for the In Vivo Evaluation of Neuroinflammation in the Rat Brain After Cortical Spreading Depression</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>2009-11</date><risdate>2009</risdate><volume>50</volume><issue>11</issue><spage>1904</spage><epage>1911</epage><pages>1904-1911</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><abstract>Neurogenic inflammation triggered by extravasation of plasma protein has been hypothesized as a key factor in the generation of the pain sensation associated with migraine. The principal immune cell that responds to this inflammation is the parenchymal microglia of the central nervous system.
Using a PET technique with (11)C-(R)-[1-(2-chlorophenyl)-N-methyl-N-(1-methyl-propyl)-3-isoquinolinecarboxamide] ((11)C-PK11195), a PET ligand for peripheral type-benzodiazepine receptor, we evaluated the microglial activation in the rat brain after generation of unilateral cortical spreading depression, a stimulation used to bring up an experimental animal model of migraine.
We found a significant increase in the brain uptake of (11)C-PK11195, which was completely displaceable by the excess amounts of unlabeled ligands, in the ipsilateral hemisphere of the spreading depression-generated rats. Moreover, the binding potential of (11)C-PK11195 in the spreading depression-generated rats was significantly higher than that in the sham-operated control rats.
These results suggest that as an inflammatory reaction, microglial cells are activated in response to the nociceptive stimuli induced by cortical spreading depression in the rat brain. Therefore, the (11)C-PK11195 PET technique could have a potential for diagnostic and therapeutic monitoring of neurologic disorders related to neuroinflammation such as migraine.</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>19837755</pmid><doi>10.2967/jnumed.109.066498</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0161-5505 |
| ispartof | The Journal of nuclear medicine (1978), 2009-11, Vol.50 (11), p.1904-1911 |
| issn | 0161-5505 1535-5667 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734115706 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Amides Animals Cerebral Cortex - diagnostic imaging Cerebral Cortex - physiopathology Cortical Spreading Depression Immunohistochemistry Isoquinolines Male Neurogenic Inflammation - diagnostic imaging Neurogenic Inflammation - physiopathology Positron-Emission Tomography Rats Rats, Sprague-Dawley |
| title | 11C-PK11195 PET for the In Vivo Evaluation of Neuroinflammation in the Rat Brain After Cortical Spreading Depression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T13%3A03%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=11C-PK11195%20PET%20for%20the%20In%20Vivo%20Evaluation%20of%20Neuroinflammation%20in%20the%20Rat%20Brain%20After%20Cortical%20Spreading%20Depression&rft.jtitle=The%20Journal%20of%20nuclear%20medicine%20(1978)&rft.au=Cui,%20Yilong&rft.date=2009-11&rft.volume=50&rft.issue=11&rft.spage=1904&rft.epage=1911&rft.pages=1904-1911&rft.issn=0161-5505&rft.eissn=1535-5667&rft_id=info:doi/10.2967/jnumed.109.066498&rft_dat=%3Cproquest_pubme%3E734115706%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=734115706&rft_id=info:pmid/19837755&rfr_iscdi=true |