Characterization of DNA and MVA vectors expressing Nef from HIV-1 CRF12_BF revealed high immune specificity with low cross-reactivity against subtype B

The HIV epidemic in Argentina is characterized by the high prevalence of infections caused by subtype B and BF variants. In this study, the Nef protein was used as a tool to study the impact of HIV-1 BF variants in the design of future vaccines. DNA and MVA vectors expressing Nef of the CRF12_BF rec...

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Veröffentlicht in:	Virus research 2009-12, Vol.146 (1), p.1-12
Hauptverfasser:	Rodríguez, A.M., Turk, G., Pascutti, M.F., Ferrer, F., Nájera, J.L., Mónaco, D., Esteban, M., Salomón, H., Calamante, G., Gherardi, M.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Vaccines - genetics AIDS Vaccines - immunology Animals Antibodies, Neutralizing - blood Cell Line Cercopithecus aethiops CMI Cricetinae Cross Reactions Genetic Vectors HIV Antibodies - blood HIV Infections - prevention & control HIV subtypes HIV-1 - genetics HIV-1 - immunology Human immunodeficiency virus 1 Immunization, Secondary - methods Interferon-gamma - secretion Leukocytes, Mononuclear - immunology Mice Mice, Inbred BALB C MVA Nef nef Gene Products, Human Immunodeficiency Virus - genetics nef Gene Products, Human Immunodeficiency Virus - immunology Vaccines Vaccines, DNA - genetics Vaccines, DNA - immunology Vaccines, Subunit - genetics Vaccines, Subunit - immunology Vaccinia virus - genetics
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