Chemical and Structural Biology to Direct the Repurposing of Sulindac

Chemical biology for medicinal chemistry: The nonsteroidal anti‐inflammatory drug sulindac was originally developed to inhibit cyclooxygenase enzymes (COX1/2) to treat inflammation and pain. Recent studies have shown that sulindac also acts on the Wnt signaling pathway, a target relevant to cancer....

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Veröffentlicht in:	ChemMedChem 2009-11, Vol.4 (11), p.1793-1795
Hauptverfasser:	Simard, Jeffrey R., Rauh, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - metabolism Anti-Inflammatory Agents, Non-Steroidal - chemistry Binding Sites cancer chemical biology Computer Simulation Cyclooxygenase Inhibitors - chemistry Dishevelled Proteins medicinal chemistry NMR Phosphoproteins - chemistry Phosphoproteins - metabolism Prostaglandin-Endoperoxide Synthases - metabolism Protein Structure, Tertiary protein-ligand interactions Signal Transduction Sulindac - chemistry Wnt Proteins - metabolism
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