Discovery of (naphthalen-4-yl)(phenyl)methanones and N-methyl- N-phenylnaphthalen-1-amines as new apoptosis inducers using a cell- and caspase-based HTS assay

The discovery and SAR studies of (naphthalen-4-yl)(phenyl)methanones and N-methyl- N-phenylnaphthalen-1-amines as novel and potent apoptosis inducers is reported. We report the discovery of a series of (naphthalen-4-yl)(phenyl)methanones as potent inducers of apoptosis using our proprietary cell- an...

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