Application of Asymmetric Ylide Cyclopropanation in the Total Synthesis of Halicholactone

Efficient shortcut: The use of the well‐known cyclopropanation reaction provided facile access to the main fragment of halicholactone with excellent enantioselectivity and diastereoselectivity in only five steps (see scheme). This enabled the total synthesis of halicholactone with an overall yield o...

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Veröffentlicht in:	Chemistry : a European journal 2009-11, Vol.15 (43), p.11465-11468
Hauptverfasser:	Zhu, Chun-Yin, Cao, Xiao-Yu, Zhu, Ben-Hu, Deng, Chao, Sun, Xiu-Li, Wang, Bi-Qin, Shen, Qi, Tang, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis cyclopropanation Cyclopropanes - chemistry halicholactone Lactones - chemical synthesis Lactones - chemistry Osmium Tetroxide - chemistry ring-closing metathesis Stereoisomerism total synthesis ylides
Online-Zugang:	Volltext
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