9-Amino Acridines Undergo Reversible Amine Exchange Reactions in Water: Implications on Their Mechanism of Action in Vivo
9-Amino substituted acridines undergo a reversible amine exchange reaction in water under near-physiological conditions via an unstable hemiaminal intermediate. This thermodynamically controlled reaction may have implications in understanding the mode of action of 9-aminoacridines in vivo and in the...
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Veröffentlicht in: | Organic letters 2009-11, Vol.11 (21), p.4894-4897 |
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creator | Paul, Alexis Ladame, Sylvain |
description | 9-Amino substituted acridines undergo a reversible amine exchange reaction in water under near-physiological conditions via an unstable hemiaminal intermediate. This thermodynamically controlled reaction may have implications in understanding the mode of action of 9-aminoacridines in vivo and in the future design of drugs based on this scaffold. |
doi_str_mv | 10.1021/ol9019925 |
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subjects | Amines - chemistry Aminoacridines - chemical synthesis Aminoacridines - chemistry Drug Design Models, Chemical Molecular Structure Water - chemistry |
title | 9-Amino Acridines Undergo Reversible Amine Exchange Reactions in Water: Implications on Their Mechanism of Action in Vivo |
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