Methyltetrahydrofolate:corrinoid/iron−sulfur Protein Methyltransferase (MeTr): Protonation State of the Ligand and Active-Site Residues

Methyltetrahydrofolate:corrinoid/iron−sulfur protein methyltransferase (MeTr) catalyzes the transfer of the N5-methyl group from N5-methyltetrahydrofolate (CH3THF) to the cobalt center of a corrinoid/iron−sulfur protein, a reaction similar to that of cobalamin-dependent methionine synthase (MetH). F...

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Veröffentlicht in:	The journal of physical chemistry. B 2009-11, Vol.113 (44), p.14787-14796
Hauptverfasser:	Alonso, Hernán, Cummins, Peter L, Gready, Jill E
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - metabolism B: Biophysical Chemistry Biocatalysis Catalytic Domain Cobalt - chemistry Corrinoids - chemistry Folic Acid Iron-Sulfur Proteins - chemistry Iron-Sulfur Proteins - metabolism Ligands Methyltransferases - chemistry Methyltransferases - metabolism Protons Pterins Quantum Theory Stereoisomerism Tetrahydrofolates - chemistry Thermodynamics
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