Extrahepatic manifestations in transgenic mice of osteopontin in hepatocytes—A clue to advent of pathological state in various organs of chronic hepatitis C patients

Osteopontin is a cytokine essential for initiation of Th1 immune reaction. We established transgenic mice expressing osteopontin in hepatocyte, in which liver necrosis with lymphocyte infiltration developed gradually from 12 weeks of age with up-regulated osteopontin levels in the circulation, sugge...

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Veröffentlicht in:	Hepatology research 2005-04, Vol.31 (4), p.197-202
Hauptverfasser:	Saitoh, Eiko, Matsui, Atsushi, Inao, Mie, Mimura, Sumie, Koh, HeaSaeng, Ohno, Akihiko, Nagoshi, Sumiko, Kayano, Hidekazu, Yoshimoto, Takayuki, Mochida, Satoshi, Fujiwara, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Interstisial pneumonia Lymphoadenopathy Osteopontin Salivary glands Splenomegaly Transgenic mouse
Online-Zugang:	Volltext
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