Effect of Pluronic-block copolymers on the reduction of serum-mediated inhibition of gene transfer of polyethyleneimine-DNA complexes

Serum stability of non‐viral vectors is a crucial factor for successful in vivo gene delivery. Pluronic‐block copolymers consisting of hydrophilic ethylene oxide and hydrophobic propylene oxide blocks were tested to prevent the reduction of serum‐mediated inhibition of gene transfer of polyethylenei...

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Veröffentlicht in:	Biotechnology and applied biochemistry 2003-06, Vol.37 (3), p.267-271
1. Verfasser:	Kuo, Jung-Hua Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Biological and medical sciences Cell Survival - drug effects Cell Survival - genetics Coated Materials, Biocompatible - chemical synthesis Coated Materials, Biocompatible - pharmacokinetics Drug Carriers - chemistry Drug Carriers - pharmacokinetics Fundamental and applied biological sciences. Psychology Gene Transfer Techniques Mice Plasmids - chemistry Plasmids - pharmacokinetics Pluronics Poloxalene - chemistry polyethyleneimine Polyethyleneimine - chemistry Polyethyleneimine - pharmacokinetics Serum - chemistry Serum - metabolism serum-mediated inhibition transfection Transfection - methods
Online-Zugang:	Volltext
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